Benign male genital dermatoses

Association of Circumcision Status with Genital Lichen Planus: A Systematic Review and Meta-analysis

“…Secondly, LP is a common dermatosis exhibiting the Koebner phenomenon. The exposed glans of the postcircumcision penis may be more vulnerable to friction or trauma (4). Thirdly, the benefits of circumcision for genital LP featured only in case reports (10), but no randomized controlled trials exist.…”

“…Male genital LP often presents with erosions with pruritus and soreness (2), and potential complications, such as scarring and phimosis, may occur (3). Management of genital LP is challenging due to a chronic relapsing course, and circumcision is suggested for patients who are refractory to conservative treatment (2,4). The benefits of circumcision for the other 2 most common causes of balanitis, namely lichen sclerosus and Zoon's balanitis (4), are well established, whereas evidence relating to the effects of circumcision on penile LP is limited.…”

Zoon Balanitis: misdiagnosis or missed diagnosis?

“…Zoonoid inflammation is already known to be associated with LSc and PeIN, both of which are already known to be associated with smoking and 'poor hygiene'. 4 2 Chapter 8. Case-control and cross sectional studies.…”

“…Indeed, in our paper, we underlined the importance of a biopsy not as much to confirm the diagnosis of ZB, but rather to exclude an erythroplasia of Queyrat, which is undoubtedly a relevant differential diagnosis to be ruled out. 4 Regarding the concerns about the control selection, we apologize for not specifying which 'skin diseases other than ZB' were included in the study, and we acknowledge that this is an important matter. We enrolled patients with genital warts, lichen sclerosus and lichen ruber planus from the STD Clinic of our Dermatology Department; all diagnoses were either clinically made by a certified dermatologist and/or histologically proven.…”

“…1 HHD is characterized by recurrent grouped vesicles, blisters and erosions restricted almost entirely to the neck and symmetrical intertriginous areas. 2 HHD is caused by mutations in ATP2C1, 3,4 which encodes an intracellular calcium ATPase pump. ATP2C1 mutations lead to haploinsufficiency, which results in abnormal intracytoplasmic calcium homoeostasis and impaired inter-keratinocyte adhesion.…”