Lexical-retrieval and semantic memory in Parkinson’s disease: The question of noun and verb dissociation

Salmazo-Silva, Henrique; Parente, Maria Alice de Mattos Pimenta; Rocha, Maria Sheila Guimarães; Baradel, Roberta Roque; Cravo, André M.; Sato, João Ricardo; Godinho, Fábio; Carthery‐Goulart, Maria Teresa

doi:10.1016/j.bandl.2016.10.006

Cited by 53 publications

(20 citation statements)

References 50 publications

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“…This conclusion is supported by previous studies (Han et al, 2015; Meltzer & McGurk, 1999; Woodward, Purdon, Meltzer, & Zald, 2005). A previous study (Salmazo‐Silva et al, 2017) measured language functions through image naming and semantic fluency tasks. The semantic fluency task belongs to processing speed and executive function of neuropsychological screening, which is impaired in patients with schizophrenia (Gleissner & Elger, 2001).…”

Section: Discussionmentioning

confidence: 99%

Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia

Dong

Yuan

Yong

et al. 2020

Human Psychopharmacology

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Background Cognitive impairment is core feature of schizophrenia. The impact of antipsychotics on cognition remains controversial. This study aimed to examine the effects of long‐term use of different types of antipsychotics on cognitive impairment in schizophrenia patients. Methods We used the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to assess the cognition of three groups of schizophrenia patients (318 on clozapine, 125 on risperidone, and 166 on typical antipsychotic drugs) and 399 healthy controls, and used the Positive and Negative Syndrome Scale to assess schizophrenia symptoms of patients. Results Patients taking typical antipsychotics scored higher on the immediate memory and delayed memory index than those taking clozapine or risperidone (all p < 0.01). Patients taking clozapine scored higher on the language subscale than those taking risperidone (p < 0.05). Multiple regression analysis showed that the drug type was identified as an independent contributor to the immediate memory, language, and delayed memory index of RBANS (all p < 0.05). Conclusions Patients taking typical antipsychotics have better memory than those taking clozapine or risperidone. Patients taking clozapine have better language function than those taking risperidone.

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Section: Discussionmentioning

confidence: 99%

Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia

Dong

Yuan

Yong

et al. 2020

Human Psychopharmacology

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“…PD is a progressive movement disorder marked by akinesia and rigid movement caused by decreased dopaminergic signaling in the basal ganglia (Jankovic, 2008). Multiple studies have shown that PD patients also exhibit a selective action verb deficit, with intact object noun knowledge (Péran et al, 2003; Rodríguez-Ferreiro, Ménendez, Ribacoba, & Cuetos, 2009; Salmazo-Silva et al, 2017). However there is some debate about the cause of this deficit: while this action verb deficit is seen as evidence for the embodied representations of action verbs, motor slowing in PD is not associated disease in the pyramidal motor system.…”

Section: Introductionmentioning

confidence: 99%

“…These studies also show that in PD patients with cognitive impairment, atrophy is widespread and also includes frontal, parietal and temporal cortical regions, causing decline in multiple cognitive domains that can affect language processing. Fronto-striatal pathophysiology in PD has been linked to reduced executive functioning and performance on action verb fluency (Obeso, Casabona, Bringas, Álvarez, & Jahanshahi, 2012; Piatt, Fields, Paolo, & Tröster, 1999; Salmazo-Silva et al, 2017). More so than motor cortex atrophy, PD is associated with disease and dysfunction of the basal ganglia, a structure which has been linked to the action verb deficits seen in PD (Cardona et al, 2013; Grossman, Stern, Gollomp, Vernon, & Hurtig, 1994; Silveri et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Production of verbs related to body movement in amyotrophic lateral sclerosis (ALS) and Parkinson's Disease (PD)

Cousins

Ash

Grossman

2018

Cortex

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Theories of grounded cognition propose that action verb knowledge relies in part on motor processing regions, including premotor cortex. Accordingly, impaired action verb knowledge in patients with amyotrophic lateral sclerosis (ALS) and Parkinson's Disease (PD) is thought to be due to motor system degeneration. Upper motor neuron disease in ALS degrades the motor cortex and related pyramidal motor system, while disease in PD is centered in the basal ganglia and can spread to frontostriatal areas that are important to language functioning. These anatomical distinctions in disease may yield subtle differences in the action verb impairment between patient groups. Here we compare verbs where the body is the agent of the action to verbs where the body is the theme. To examine the role of motor functioning in body verb production, we split patient groups into patients with high motor impairment (HMI) and those with low motor impairment (LMI), using disease-specific measures of motor impairment. Regression analyses assessed how verb production in ALS and PD was related to motor system atrophy. We find a dissociation between agent- and theme-body verbs in ALS: ALS HMI were impaired for agent body verbs but not theme verbs, compared to ALS LMI. This dissociation was not present in PD patients, who instead show depressed production for all body verbs. Although patients with cognitive impairment were excluded from this study, cognitive performance significantly correlated with the production of theme verbs in ALS and cognitive/stative verbs in PD. Finally, regression analyses related the agent-theme dissociation in ALS to grey matter atrophy of premotor cortex. These findings support the view that motor dysfunction and disease in premotor cortex contributes to the agent body verb deficit in ALS, and begin to identify some distinct characteristics of impairment for verbs in ALS and PD.

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“…Salmazo-Silvo et al (55) used verbal fluency tasks involving nouns and verbs, naming and semantic association tasks in patients with PD and healthy controls to investigate the Embodied Cognition Theory. Both groups exhibited similar performance in verbal fluency tasks.…”

Section: Action-related Language Disturbances In Parkinson's Diseasementioning

confidence: 99%

Neural Foundations of Action-related Language: Studies in Parkinson’s Disease

Bayram¹,

Akbostancı²

2018

tnd

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Lexical-retrieval and semantic memory in Parkinson’s disease: The question of noun and verb dissociation

Cited by 53 publications

References 50 publications

Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia

Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia

Production of verbs related to body movement in amyotrophic lateral sclerosis (ALS) and Parkinson's Disease (PD)

Neural Foundations of Action-related Language: Studies in Parkinson’s Disease

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