Lewis Antigen Expression in Gastric Mucosa of Children: Relationship With Helicobacter pylori Infection

Nogueira, Ana Margarida Miguel Ferreira; Marques, Terezinha Sasaki; Soares, Paula; David, Leonor; Reis, Celso A.; Serpa, Jacinta; Queiroz, Dulciene Maria Magalhães; Rocha, Gifone Aguiar; Rocha, Andréia C.

doi:10.1097/00005176-200401000-00019

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…Helicobacter pylori symptom profiles in children reflect an interplay between the chronicity of infection, the host's immune response [15,39,40], heterogeneity of bacterial virulence [25,26,41,42], and the ability of a child to report and describe symptoms. In addition, psychological symptoms, unfamiliarity with foods and language may contribute to and ⁄ or alter patterns of…”

Section: Discussionmentioning

confidence: 99%

Associations Between Helicobacter pylori Infection, Co‐Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Associations Between Helicobacter pylori Infection, Co‐Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

et al. 2010

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“…H. pylori Le antigens expression depends on the time of the bacterial growth being mostly expressed in a growth phase-dependent manner. Different patterns of Le antigens' expression were observed in adults and children-for instance, Le b expression correlates with the bacterial distribution within the antrum and corpus of the adult patients, whereas in children, it might increase the risk of ulceration [137,138]. Furthermore, there are differences in the Le antigens' expression regarding symptomatic and asymptomatic H. pylori-infected individuals; asymptomatic individuals tend to present significantly lowered expression of Le x antigen and the complete absence of type 1 Lewis antigens, compared to the infected symptomatic individuals [139].…”

Section: Lewis Antigensmentioning

confidence: 99%

Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment

Baj

Forma

Sitarz

et al. 2020

Cells

201

163

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Gastric cancer constitutes one of the most prevalent malignancies in both sexes; it is currently the fourth major cause of cancer-related deaths worldwide. The pathogenesis of gastric cancer is associated with the interaction between genetic and environmental factors, among which infection by Helicobacter pylori (H. pylori) is of major importance. The invasion, survival, colonization, and stimulation of further inflammation within the gastric mucosa are possible due to several evasive mechanisms induced by the virulence factors that are expressed by the bacterium. The knowledge concerning the mechanisms of H. pylori pathogenicity is crucial to ameliorate eradication strategies preventing the possible induction of carcinogenesis. This review highlights the current state of knowledge and the most recent findings regarding H. pylori virulence factors and their relationship with gastric premalignant lesions and further carcinogenesis.

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“…In children, the expression of the Le x antigen, but not the Le b superficial expression, was associated with duodenal ulcers with H. pylori [22]. Based on an in vitro study, a known Le b -binding H. pylori revealed significantly lower binding to gastric tissues from children and adolescents than to tissues from adults [23].…”

Section: Introductionmentioning

confidence: 97%

Helicobacter pylori infection can change the intensity of gastric Lewis antigen expressions differently between adults and children

Yang

Sheu

et al. 2007

J Biomed Sci

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This study tested whether there were different expressions of gastric Lewis antigens between children and adults with Helicobacter pylori infection, and whether the difference was related to the infection outcome. About 68 dyspeptic children and 110 dyspeptic adults were enrolled to check H. pylori infection, its colonization density, and the related histology. Gastric Lewis antigens b (Le(b)), x (Le(x)), and sialyl-Lewis x (sialyl-Le(x)) were immunohistochemically stained and scored for the intensity. The H. pylori-infected adults, but not the children, had a lower Le(b) intensity over the antrum (p=0.019) but higher Le(b) intensity over the corpus (p=0.001) than the non-infected ones. Over the antrum, both the H. pylori-infected children and adults had a lower Le(x) and higher sialyl-Le(x) intensity than those non-infected ones (p<0.05). The H. pylori-infected adults had a higher bacterial density (p=0.004) and Le(b) intensity (p=0.016) over the corpus than the H. pylori-infected children. For the H. pylori-infected adults, but not children, the corpus had a higher Le(b) (p=0.038) and lower Le(x) (p=0.005) intensity than the antrum. Furthermore, the H. pylori-infected adults expressed a higher Le(b) and had a higher bacterial density than those with weak Le(b) (antrum, p<0.001; corpus, p=0.001). In conclusion, H. pylori infection is associated with the intensity change of Lewis antigen expressions in the stomach. The changes of gastric Lewis antigen expressions are different between adults and children with H. pylori infection, which may exert different H. pylori colonization over the corpus between adults and children.

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Lewis Antigen Expression in Gastric Mucosa of Children: Relationship With Helicobacter pylori Infection

Cited by 10 publications

References 27 publications

Associations Between Helicobacter pylori Infection, Co‐Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

Associations Between Helicobacter pylori Infection, Co‐Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment

Helicobacter pylori infection can change the intensity of gastric Lewis antigen expressions differently between adults and children

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