Associations Between <i>Helicobacter pylori</i> Infection, Co‐Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

Cherian, Sarah; Burgner, David; Cook, Angus; Sanfilippo, Frank M; Forbes, David

doi:10.1111/j.1523-5378.2009.00740.x

Cited by 18 publications

(24 citation statements)

References 58 publications

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“…[10] showed significant differences in H. pylori prevalence between Pacific Island (49.0%) vs. Maori (26.7%) and Asian (24.7%) vs. European adolescents (13.7%). Several studies on children and adolescents in Asia showed prevalence rates ranging from 20% to 84% [12–15]. Overall, as expected, the H. pylori prevalence rates from the Asia‐Pacific region were high except among the white population of Australia and New Zealand.…”

Section: Prevalencesupporting

confidence: 57%

“…We have grouped the studies according to the different geographical regions for ease of reference (Table 1). There were 10 studies from the Asia‐Pacific region on adults [2–11] and 4 on children [12–15]. Li et al.…”

Section: Prevalencementioning

confidence: 99%

“…Overall, as expected, the H. pylori prevalence rates from the Asia‐Pacific region were high except among the white population of Australia and New Zealand. The prevalence of H. pylori infection was generally lower among children except for the one study from India [13] and another looking at African refugee children from resettlement in Western Australia [14].…”

Section: Prevalencementioning

confidence: 99%

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Epidemiology of Helicobacter pylori Infection and Public Health Implications

et al. 2011

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This review summarizes studies on the epidemiology and public health implications of Helicobacter pylori published in peer-reviewed journals from April 2010 through March 2011. Prevalence rates vary widely between different geographical regions and ethnic groups. An interesting study from the USA identified the degree of African ancestry as an independent predictor of H. pylori infection. Two studies have demonstrated early childhood as the period of transmission of infection and identified an infected sibling as an important risk factor. An oral–oral route of spread has been substantiated with several studies showing the presence of H. pylori in the oral cavity. Studies have shown the presence of H. pylori in drinking water and the role of poor living conditions and sanitation in H. pylori infection, supporting an oral–fecal route of spread. Screening for H. pylori as a gastric cancer prescreening strategy has been described in Japan, and the importance of H. pylori eradication as a gastric cancer–prevention strategy has now been further emphasized in Japanese guidelines. Two studies have shown a decrease in the burden of dyspepsia and peptic ulcer disease with H. pylori eradication.

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Section: Prevalencesupporting

confidence: 57%

Section: Prevalencementioning

confidence: 99%

Section: Prevalencementioning

confidence: 99%

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Epidemiology of Helicobacter pylori Infection and Public Health Implications

et al. 2011

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“…T. trichiura is a candidate for future study because it was prevalent in Tumaco children [18], and Al and T. trichiura infections in poor Brazilian children were associated with enhanced IL-5 and IL-10 production by peripheral blood mononuclear cells along with hyporesponsiveness to mitogen stimulation in culture [51]. Our data are also consistent with elevated serum levels of IL-5, IL-10, and TNFa with an elevated IL-10 ⁄ IL-12 ratio in asymptomatic African refugee children concurrently infected with Hp, malaria, and helminths [52].…”

Section: Parasites and H Pylori In Colombianssupporting

confidence: 81%

Serologic Evidence that Ascaris and Toxoplasma Infections Impact Inflammatory Responses to Helicobacter pylori in Colombians

Whary

Ihrig

et al. 2012

Helicobacter

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Background Helicobacter pylori infected children from coastal Tumaco, Colombia have more parasitism, and adults have lower gastric cancer risk compared to high altitude Pasto/Tuquerres residents. Because helminth and Toxoplasma gondii infections alter helicobacter gastritis in rodent models, we determined if seropositivity to Ascaris lumbricoides or T. gondii was associated with Th2-IgG1 or Th1-IgG2 responses to H. pylori. Methods Sera (240) from the two populations were evaluated for A. lumbricoides and T. gondii seropositivity and results correlated with IgE and IgG isotype responses to H. pylori. Results Most Tumaco children and adults were seropositive for A. lumbricoides (89%, 66%), T. gondii (59%, 98%) or both (45%, 66%). In contrast, seropositivity among Pasto/Tuquerres children was much lower (9% A. lumbricoides, 11% T. gondii and 2% dual positive) but increased in adults (58% A. lumbricoides, 82% T. gondii and 41% dual positive). A. lumbricoides seropositivity correlated with elevated IgE and anti-inflammatory Th2-IgG1 responses to H. pylori, while Toxoplasma gondii seropositivity was linked to elevated IgE, pro-inflammatory Th1-IgG2, IgG3 and IgG4 responses to H. pylori. Individuals with high T. gondii titers had reduced Th1-IgG2, IgG3 and IgG4 responses to Helicobacter pylori. Conclusions Results support regional differences for childhood parasitism and indicate A. lumbricoides and T. gondii infections may impact inflammatory responses to H. pylori and partially explain differences in gastric cancer risk in Colombia.

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“…There are continued reports of the lack of relationship between H. pylori infection and abdominal symptoms [10,17–19]. In Nigeria, Senbanjo et al.…”

Section: Gastrointestinal Manifestationsmentioning

confidence: 99%

Helicobacter pylori in Pediatrics

Sýkora

Rowland

2011

Helicobacter

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This article reviewed the important publications on Helicobacter pylori research with children between April 2010 and March 2011. The most interesting studies in the last year lend further weight to the evidence for vertical transmission of H. pylori. The discovery of a potential role for jhp0562, the gene which encodes for the cell envelope protein glycosyltransferase, in the progression to peptic ulcer disease is also very interesting as it may provide a novel way to distinguish children at risk of peptic ulcer disease from those who are not, and so determine those who requires treatment to eradicate H. pylori. The rise in non‐H. pylori‐associated ulcers and erosions continues to be reported with no apparent risk factors for these ulcers identified to date. High levels of treatment failure continue to be reported, and there remains an urgent need for more effective treatment regimes for children.

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Associations Between Helicobacter pylori Infection, Co‐Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

Cited by 18 publications

References 58 publications

Epidemiology of Helicobacter pylori Infection and Public Health Implications

Epidemiology of Helicobacter pylori Infection and Public Health Implications

Serologic Evidence that Ascaris and Toxoplasma Infections Impact Inflammatory Responses to Helicobacter pylori in Colombians

Helicobacter pylori in Pediatrics

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