Levels of metals and organic substances in workers at a hazardous waste incinerator: a follow-up study

Mari, Montse; Schuhmacher, Marta; Domingo, José L.

doi:10.1007/s00420-008-0350-0

Cited by 22 publications

(12 citation statements)

References 48 publications

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“…The European food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. Ni concentrations in urine of the three groups of workers (plant, laboratory and administrative) at a Spanish incinerator were significantly lower than those of the baseline survey suggesting that there was no occupational Ni exposure (Mari et al, 2009). Ni concentration in scalp hair was increased in patients admitted to hospital in Hyderabad, Pakistan suffering with myocardial infarction and levels were higher in third-attack patients as compared to first-and second-attack patients (Afridi et al, 2010).…”

Section: Discussionmentioning

confidence: 81%

Collate literature data on toxicity of Chromium (Cr) and Nickel (Ni) in experimental animals and humans

Casalegno¹,

Schifanella²,

Zennaro³

et al. 2015

EFSA Supporting Publications

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Literature data on Chromium show that trivalent chromium has low acute and long term toxicity whilst hexavalent chromium is acutely toxic and produces long term effects on hematological parameters and liver. Continuous exposure to high concentrations of hexavalent chromium in drinking water results in intestinal tumors in mice but not rats. However, evidence of the carcinogenic potential of chromium has been demonstrated in rats but not consistently in mice. Cr (III) organic complexes (chromium picolinate) did not show evident adverse effects after repeated oral exposure. Both in vitro and in vivo data show that trivalent chromium is not genotoxic whilst hexavalent chromium is genotoxic. Chromium has been shown to affect sperm, estrous cycle and fetal development. Human toxicity data reveals mixed results but there is some evidence that hexavalent chromium can increase the risk of cancer. Data on Nickel show that nickel soluble compounds (nickel sulphate, nickel chloride or nickel nitrate) have acute and long term toxicity and produce oxidative stress and long term effects on liver. Less soluble compounds (nickel sulfides or nickel oxides) are less toxic. Nickel shows genotoxic effects both in vitro and in vivo. Only a limited number of studies on carcinogenic effects after oral exposure to nickel compounds are available. These studies showed no neoplastic effects in rats after oral administration. Nickel has been shown to affect sperm, live litter size and post-implantation loss. Teratogenic effects are reported on Amphibian embryos. Nickel can affect neurodifferentiation, the T-cell system and suppress the activity of natural killer cells. Human data reveals that nickel is excreted in the urine following oral exposure and that this increases with increasing age. There is some evidence that nickel might promote oral cancer etiology but no clear evidence that nickel can increase the risk of respiratory cancer.

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Section: Discussionmentioning

confidence: 81%

Collate literature data on toxicity of Chromium (Cr) and Nickel (Ni) in experimental animals and humans

Casalegno¹,

Schifanella²,

Zennaro³

et al. 2015

EFSA Supporting Publications

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“…These results showed a significant decrease (p<0.01) when compared to the levels of the baseline study conducted by Domingo et al (2001). Eight years after the beginning of the operations in the plant, Mari et al (2009) re-assessed the exposure in 29 workers. Plasma levels of PCBs 28, 52 and 101 were significantly lower than their respective control values, while congeners 138, 153 and 180 had decreased notably, but not significantly.…”

Section: Table Imentioning

confidence: 90%

Concentrations of persistent organic pollutants in blood of the Spanish population: Temporal trend

González¹,

Domingo²

2021

Arhiv za farmaciju

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The present article reviews the human biomonitoring studies conducted in Spain to assess exposure to persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), polybrominated diphenyl ethers (PBDEs), and per- and poly-fluoroalkyl substances (PFAS). In general terms, important variations in POPs concentrations between Spanish regions and specific populations were observed, while no associations between exposure to POPs and adverse health outcomes were found. Moreover, occupational exposure seems not to be a risk factor with regards to POPs exposure in the Spanish population. The present review highlights the importance of conducting human biomonitoring studies to find possible associations between POPs and adverse health effects.

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“…In subsequent studies, the mean PCDD/F levels have continuously decreased in parallel to the reductions also observed in the general population of the area [26], which in turn have been mainly attributed to the considerable decrease in the concentrations of PCDD/Fs in the most consumed foodstuffs in the area [16]. These are mean concentrations (ng I-TEQ/kg fat) of PCDD/Fs in pooled plasma samples of the workers at the HWI: 16.9 (2000), 10.3 (2002), 10.4 (2004), 5.5 (2008), 4.4 (2010,) and 4.6 (2011) [60,61,62,63,64].…”

Section: Concentrations Of Pcdd/fs In a Number Of Countriesmentioning

confidence: 99%

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Marquès

Domingo

2019

IJERPH

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Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) are environmental pollutants with great persistence, the capacity of bioaccumulation, and well known important toxic effects in humans and animals. Incinerators of hazardous, municipal and medical waste, chlorine bleaching of paper pulp, cement plants, and the traffic of motor vehicles are the most frequent emission sources of these compounds. The diet, followed at a great distance by inhalation, is generally the main way of human exposure to PCDD/Fs. Human biomonitoring is of great importance to prevent potential adverse effects derived from exposure to chemicals such as PCDD/Fs. In relation to this, blood is among the most used biological monitors. In the current review, we have summarized the recent information (2000–2009) published in the scientific literature (databases: Scopus and PubMed) on the concentrations of PCDD/Fs in blood samples of non-occupationally exposed populations, as well as in some groups of occupationally exposed individuals. We have revised a number of studies conducted in various African, American, Asian and European countries, and Australia. Unfortunately, the information is quite limited. No data are available for most countries over the world. Based on the results here reviewed, where available, the current health risks for the general populations do not seem to be of concern. Moreover, taking into account the important reductions observed in the levels of PCDD/Fs in foodstuffs, new decreases in the concentrations of PCDD/Fs in blood—and other biological tissues—are very probable in the immediate years.

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Levels of metals and organic substances in workers at a hazardous waste incinerator: a follow-up study

Abstract: According to the results of the present study, there are no evident signs of occupational exposure to a number of metals and organic substances in the workers of the HWI.

Cited by 22 publications

References 48 publications

Collate literature data on toxicity of Chromium (Cr) and Nickel (Ni) in experimental animals and humans

Collate literature data on toxicity of Chromium (Cr) and Nickel (Ni) in experimental animals and humans

Concentrations of persistent organic pollutants in blood of the Spanish population: Temporal trend

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

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