Twenty-five patients with Hodgkin's disease and high eosinophil counts were observed for an average of 90 months. Fluctuations in the levels of eosinophils were important in the course of observation. No relation with stages, histologic type, or evolution was noticed. Steroidcontaining regimens and severe premortem conditions seemed to lower the counts. Relapse-free survival was shorter in our 25 patients than in a control group of 50 patients with Hodgkin's disease and no eosinophilia who had approximately the same stage, histologic type, and treatment of disease. However, the overall survival was somewhat better for the eosinophilic patients with stages IIIB and IV (0.1 > P > 0.05). Cancer 1992; 691248-1253.Blood eosinophilia in cancer is an uncommon phenomenon found in a relatively small number of cases.' Hodgkin's disease (HD) is an exception, being the malignancy in which eosinophilia occurs at a frequency of approximately 1570. ' The association of HD with tissue eosinophilia was known some years before Dorothy Reed described the cells that now bear her name and before she reported the presence of numerous eosinophils in the tissues.3r4 Although blood eosinophilia in HD was reported more than 50 years ago by some a~t h o r s ,~,~ the finding was not considered significant.' However, a recent article7 reports a better survival rate of patients with HD and blood eosinophilia.The current study reports the follow-up of 25 cases of HD with blood eosinophilia during an average of 90 months.