Eosinophilia in early-stage human immunodeficiency virus infection

Sánchez-Borges, Mario; Orozco, Ana Monzón de; Biagio, Elizabeth Di; Tami, Irene; Suárez-Chacón, Raúl

doi:10.1016/0091-6749(93)90130-8

Cited by 16 publications

(7 citation statements)

References 5 publications

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“…Total lymphocyte count and anaemia have already been proposed as prognostic markers during HIVinfection 11,29± 33 . In contrast with observations made in industrialized countries 34 , a`paradoxal eosinopenia' is associated with advanced stages of HIV infection in areas where parasitic diseases are prevalent, as previously reported by ourselves and others 35,36 (Figure 2). In our strategy, we preferred to favour an increase in the positive predictive value of the model, as a positive score should have a therapeutic consequence for the patient.…”

contrasting

confidence: 76%

A proposal for basic management of HIV disease in West Africa: use of clinical staging and haemogram data

Ledru¹,

Diagbouga²,

Méda³

et al. 1998

Int J STD AIDS

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Our objective was to propose a strategy to screen HIV-infected African people for biological immunodeficiency easily. In a cross-sectional study, we analysed the patterns of diseases and of CD4 counts among 266 HIV-infected adults. Peripheral facial paralysis and chronic cutaneo-mucous diseases were the earlier B-stage diseases. Pulmonary tuberculosis was close to B-stage diseases, and chronic diarrhoea was borderline between B and C stages. Cachexia was the most frequent C-stage symptom (47.8%). Ninety per cent of CDC-C stage people had CD4 counts below 350/microliter, whereas only 75% had CD4 counts below 200/microliter. Regression analysis identified the lymphocyte count, clinical stage and platelet count as predictors of CD4 count below 350/microliter. A simple score (lymphocyte count < or = 2500/microliter and clinical stage > or = B) is proposed to determine this CD4 threshold (positive predictive value: 83%) and to determine those patients needing treatment to prevent wasting and opportunistic infections.

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contrasting

confidence: 76%

A proposal for basic management of HIV disease in West Africa: use of clinical staging and haemogram data

Ledru¹,

Diagbouga²,

Méda³

et al. 1998

Int J STD AIDS

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“…2). We found similar results in human immunodeficiency virus infection, where eosino phils were increased in early stages of infection and de creased counts were present in advanced infection, while IgE was elevated even at later stages of the disease [9]. These results cannot be attributed to parasitic infesta tions, which are highly prevalent in the tropics, since our 2 patients who had parasites in their stools did not have in creased eosinophils or IgE, nor can they be explained by the presence of atopy, since there were no significant differenc es in eosinophil counts or serum IgE levels between atopic and nonatopic HD patients.…”

Section: Eosinophil Survival Assaysupporting

confidence: 73%

Eosinophilia in Hodgkin’s Disease: A Role for Interleukin 5

Biagio¹,

Sánchez‐Borges²,

Desenne

et al. 1996

Int Arch Allergy Immunol

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In order to clarify the mechanisms of the eosinophilia frequently observed in patients with Hodgkin’s disease (HD), 18 patients and 16 age- and sex-matched controls were studied. Increased eosinophil numbers in peripheral blood and serum IgE, as well as decreased cell-mediated immunity were present in HD patients compared with control individuals. Advanced disease was accompanied by lower eosinophil levels, increased IgE, and lower CD4+ T cell counts in peripheral blood. Eosinophilia correlated with CD4+ T cell counts, suggesting that eosinophil production could be under CD4+ T cell control. GM-CSF production in vitro by Phytohemaglutinin-stimulated mononuclear cells was significantly lower in HD patients with eosinophilia. On the other hand, an eosinophil-survival-enhancing activity was found in sera and culture supernatants from controls and HD patients; this activity was stronger for HD patients and was higher for those with eosinophilia. Furthermore, this activity was completely abolished by preincubation with monoclonal antibodies to IL-5, but not with normal mouse serum. Our results suggest that defects of cell-mediated immunity present in patients with HD are accompanied by a predominant type 2 cytokine profile. IL-5 is involved in the increased eosinophil production observed in these patients.

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“…The occurrence of peripheral blood eosinophilia in patients with human immunodeficiency type 1 (HIV-1) infection has been described previously (1)(2)(3)(4). Our daily clinical work suggested that eosinophilia is more common in late-stage infection.…”

Section: Eosinophilia In Patientsmentioning

confidence: 64%