Blood eosinophilia in hodgkin's disease: A follow‐up of 25 cases in Venezuela

Abstract

Twenty-five patients with Hodgkin's disease and high eosinophil counts were observed for an average of 90 months. Fluctuations in the levels of eosinophils were important in the course of observation. No relation with stages, histologic type, or evolution was noticed. Steroidcontaining regimens and severe premortem conditions seemed to lower the counts. Relapse-free survival was shorter in our 25 patients than in a control group of 50 patients with Hodgkin's disease and no eosinophilia who had approximately the same stage, histologic type, and treatment of disease. However, the overall survival was somewhat better for the eosinophilic patients with stages IIIB and IV (0.1 > P > 0.05). Cancer 1992; 691248-1253.Blood eosinophilia in cancer is an uncommon phenomenon found in a relatively small number of cases.' Hodgkin's disease (HD) is an exception, being the malignancy in which eosinophilia occurs at a frequency of approximately 1570. ' The association of HD with tissue eosinophilia was known some years before Dorothy Reed described the cells that now bear her name and before she reported the presence of numerous eosinophils in the tissues.3r4 Although blood eosinophilia in HD was reported more than 50 years ago by some a~t h o r s ,~,~ the finding was not considered significant.' However, a recent article7 reports a better survival rate of patients with HD and blood eosinophilia.The current study reports the follow-up of 25 cases of HD with blood eosinophilia during an average of 90 months.

Eosinophilia in routine blood samples and the subsequent risk of hematological malignancies and death

“…However, since moderate to severe lymphocytosis correlates well with the presence of CLL, this blood cell is a better candidate for early warning for this specific disease entity than the eosinophil despite of the association found in the present analyses. Nevertheless, it is an interesting hypothesis that eosinophilia correlates with improved outcomes for CLL patients, which has been proposed in cases of eosinophilia in HL . Unfortunately, the CopDiff database does not permit an approach to determine the prognostic impact of this new observation due to the long natural course of CLL.…”

“…Hodgkin's lymphoma (HL) is a classic example of a hematologic, extrinsic disorder accompanied by blood eosinophilia in about 15% of cases. This observation appears to be associated with a survival advantage in patients with mixed cellularity and nodular sclerosis histology in some , but not all studies . Eosinophilia in non‐HL (NHL) is primarily confined to T‐cell disorders, and may in these cases contribute to the clinical presentation as a reactive, non‐clonal phenomenon .…”

Successful Chemotherapy Following Autologous Stem Cell Transplantation in Multiple Myeloma and Multi-organ Dysfunction with Infiltration of Eosinophils: A Case Report

“…A number of lymphoid neoplasms may be accompanied by eosinophilia, including Hodgkin's disease and T-cell lymphomas and, less frequently, B-cell non-Hodgkin's lymphomas, natural killer cell neoplasms, and other B cell malignancies [2,3,5]. There have been some case reports of eosinophilia associated with lymphoid malignancies [10,11]. However, there have been few reports on eosinophilia with MM or plasma cell disorders [6,7].…”

Anaplastic Large Cell Lymphoma with Massive Eosinophilia and Complex Karyotype Initially Misdiagnosed as Chronic Eosinophilic Leukemia

“…eISSN 2093-6338 as causes of secondary hypereosinophilia [5,6]. Particularly, anaplastic large cell lymphoma (ALCL) is one of the T-cell lymphomas accompanied by secondary eosinophilia.…”