Successful Chemotherapy Following Autologous Stem Cell Transplantation in Multiple Myeloma and Multi-organ Dysfunction with Infiltration of Eosinophils: A Case Report

Abstract

Eosinophils are derived from hematopoietic stem cells. Peripheral blood eosinophilia is defined as an absolute eosinophil count of ≥0.5×109/L. Eosinophilia is classified into primary or clonal eosinophilia, secondary eosinophilia, and idiopathic categories including idiopathic hypereosinophilic syndrome. Both hematopoietic and solid neoplasms may be associated with peripheral blood eosinophilia, but multiple myeloma is rarely associated with eosinophilia. We now report the case of a 31-year-old man with multiple myeloma associated with marked eosinophilia who developed multiple organ dysfunction with infiltration of eosinophils. He recovered after treatment with chemotherapy followed by autologous stem cell transplantation.

Progression from light chain myeloma to secondary plasma cell leukemia accompanied by peripheral blood eosinophilia

“…In most of the published cases, the myeloma cells expressed heavy chains (IgG: 4, IgA: 2, biclonal: 1), and only one patient, like in the present case, had a LCM [4,7,8]. To our knowledge, PBE as presenting sign of secondary PCL, evolving from MM or LCM, has not been described so far.…”

Subepidermal Bullous Dermatosis Associated With IgA Multiple Myeloma

“…[6][7][8][9] In addition, peripheral eosinophilia has been associated with plasma cell disorders via several hypothesized mechanisms. [10][11][12] Moreover, the observation that fall and rise of serum IgA paraprotein levels were mirrored by the pattern of resolution and exacerbation of the eruptions suggested that the link between subepidermal bullae and the presence of excess IgA paraprotein in the serum was more than merely coincidental. As only the markedly elevated IgA kappa paraprotein was found on serum immunoelectrophoretogram, we suppose that the positive kappa light chain on IHC staining was IgA paraprotein.…”

Anemia Hemolitik Autoimun (AIHA) dan hipereosinofillia pada pasien Multiple Myeloma di RS Saiful Anwar, Malang

“…Pada pasien ini, didapatkan peningkatan eosinofil, yang dapat dikategorikan sebagai eosinofilia sekunder karena multiple myeloma. (Ho Sup et al, 2011) Hipereosinofillic syndrome (HES) ditandai dengan suatu produksi yang berlebihan eosinophil yang melibatkan suatu gangguan organik. Diagnosis suatu idiopatik HES berdasar kriteria Chusid's yaitu penanda eosinofillia (Absolute Eosinophilic Count > 1500x 10 6 /L), berlangsung kronis (> 6 bulan), tidak didapatkan penyebab sekunder hipereosinophilia dan tanda dan gejala eosinophil tissue injury.…”