Levels of EGF and VEGF in patients with primary and secondary Sjögren’s syndrome

Błochowiak, Katarzyna; Trzybulska, Dorota; Olewicz‐Gawlik, Anna; Sikora, Jan; Nowak-Gabryel, Michalina; Kocięcki, Jarosław; Witmanowski, Henryk; Sokalski, Jerzy

doi:10.17219/acem/70800

Cited by 9 publications

(9 citation statements)

References 31 publications

(48 reference statements)

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“…Squamous metaplasia of the ocular surface epithelium, follicular conjunctivitis, corneal epitheliopathy, recurrent erosion, and corneal ulceration were also described in SS [11]. The rate of dry mouth in SS ranged from 41% at initial diagnosis to 84% 10 years after diagnosis [12]. According to SS classification criteria, an unstimulated salivary flow rate of 0.1 ml/min in sialometry gives a score of 1 to the weighted sum of five items.…”

Section: Xerostomia and Xerophthalmia In Differentiative Diagnosis Ofmentioning

confidence: 99%

Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

Kamiński¹

2020

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Mikulicz's disease and Sjögren's syndrome involve salivary glands. They are characterised by lymphocytic infiltrations in affected exocrine glands leading to their swelling and dysfunction. Although they present similar clinical symptoms, currently they belong to different classifications and require different multidisciplinary treatments. This study presents and compares Sjögren's syndrome and Mikulicz's disease and reviews their main clinical, histopathological, and serologic criteria and the methods used in the diagnostic process. The most reliable diagnostic method is histopathologic examination of glandular tissue obtained by either minor or major salivary gland biopsies. Serologic criteria play an additional diagnostic role. The different radiological modalities allow the exclusion of other inflammatory and neoplastic processes that can mimic the initial stages of Mikulicz's disease and Sjögren's syndrome. Streszczenie Choroba Mikulicza i zespół Sjögrena zajmują gruczoły ślinowe. Charakteryzują się naciekami limfocytarnymi w zajętych gruczołach zewnątrzwydzielniczych, co prowadzi do ich obrzęku i dysfunkcji. Chociaż oba te schorzenia cechuje podobny obraz kliniczny, obecnie są odmiennie klasyfikowane i wymagają innego leczenia wielospecjalistycznego. W artykule przedstawiono chorobę Mikulicza oraz zespół Sjögrena i porównano je ze sobą. Omówiono ich główne kryteria kliniczne, histopatologiczne i serologiczne, a także metody stosowane w diagnostyce. Badanie histopatologiczne tkanki gruczołowej pobranej z małych lub dużych gruczołów ślinowych jest najpewniejszą metodą diagnostyczną. Badania serologiczne odgrywają dodatkową rolę. Różne metody radiologiczne pozwalają na wykluczenie procesów nowotworowych i zapalnych, które w początkowych fazach choroby mogą naśladować zespół Sjögrena i chorobę Mikulicza.

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Section: Xerostomia and Xerophthalmia In Differentiative Diagnosis Ofmentioning

confidence: 99%

Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

Kamiński¹

2020

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“…If lacrimal glands are affected, it is called Mikulicz disease. However, the clinical presentation of SS covers a broad spectrum with variable combinations of systemic extra-glandular manifestations such as peripheral neuropathy, arthralgia, lung disease, skin and mucosa manifestations, and other features [5][6][7][8][9][10][11]. The population prevalence of SS has been estimated at 0.5-1%, and the male/female ratio is approximately 1 : 9.…”

Section: Labial Salivary Gland Biopsy In Diagnosing and Monitoring Sjmentioning

confidence: 99%

“…The population prevalence of SS has been estimated at 0.5-1%, and the male/female ratio is approximately 1 : 9. Sjögren's syndrome can occur as a primary disease (pSS) or in association with another connective tissue disease as a secondary SS (sSS) [5][6][7][8][9][10][11]. The presence of mononuclear cell aggregates around the ducts and acini of exocrine glands result in functional and structural alternations at the level of these glands and impair their secretory function [4].…”

Section: Labial Salivary Gland Biopsy In Diagnosing and Monitoring Sjmentioning

confidence: 99%

“…Previous classifications of SS were based on the combination of both objective and subjective tests. They included clinical, serological, and histopatho-logical features of SS [7][8][9][10]. The current diagnostic criteria of SS, approved in 2016 by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR), are based on the sum of five items: anti-SSA/Ro antibody positivity and focal lymphocytic sialadenitis (FLS) with a focus score of 1 foci/4 mm 2 , each scoring 3; an abnormal ocular staining score of 5 (or a van Bijsterveld score of 4); a Schirmer's test result of 5 mm/5 min; and an unstimulated salivary flow rate of 0.1 ml/minute, each scoring 1.…”

Section: Labial Salivary Gland Biopsy In Diagnosing and Monitoring Sjmentioning

confidence: 99%

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The unknown face of labial salivary glands. Labial salivary gland biopsy as a diagnostic tool

Kamiński¹,

Guzera²

2019

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Labial salivary gland biopsy (LSGB) is a minimally invasive and safe surgical procedure performed in the diagnosis and monitoring of selected diseases such as Sjögren's syndrome (SS), sarcoidosis, and amyloidosis. The aim of this study is to present the main possibilities and indications for the usefulness of LSGB in these diseases, their histopathological criteria, and the main advantages and limitations. Histopathological confirmation of SS is based on the presence of lymphocytic infiltrates, known as focal lymphocytic sialadenitis (FLS). FLS refers to the histopathological pattern of the presence of one or more foci in the biopsies, while the tissue surrounding the foci is composed mainly of unaffected parenchyma. A focus is defined as an aggregate of ≥ 50 lymphocytes, and the focus score (FS) is the total number of foci per 4 mm 2 of salivary gland tissue. FLS should be distinguished from other types of sialadenitis such as nonspecific chronic sialadenitis, sclerosing chronic sialadenitis, granulomatous inflammation, and lymphomas. Streszczenie Biopsja wargowych gruczołów ślinowych (LSGB) jest minimalnie inwazyjnym i bezpiecznym zabiegiem chirurgicznym wykorzystywanym w diagnostyce i monitorowaniu wybranych chorób, takich jak zespół Sjögrena (SS), sarkoidoza, amyloidoza. Celem pracy było przedstawienie głównych możliwości i wskazań do zastosowania LSGB, kryteriów histopatologicznych, głównych zalet i ograniczeń. Histopatologiczne potwierdzenie SS opiera się na stwierdzeniu obecności nacieków limfocytarnych znanych jako ogniskowe limfocytarne zapalenie gruczołów ślinowych (FLS). Nazwa FLS odnosi się histopatologicznie do obecności jednego lub więcej ognisk w biopsji, podczas gdy ognisko jest otoczone głównie przez niezmienioną tkankę miąższową. Ognisko jest definiowane jako skupisko 50 lub więcej limfocytów, a wynik jest liczbą ognisk przypadającą na 4 mm 2 tkanki gruczołowej. Ogniskowe limfocytarne zapalenie gruczołów ślinowych powinno być różnicowane z innymi typami zapalenia, takimi jak niespecyficzne zapalenie gruczołów ślinowych, twardniejące przewlekłe zapalenie gruczołów ślinowych, zapalenie ziarniniakowe i chłoniaki.

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“…The clinical features involve a wide variety of organs, including skin, eyes, oral cavity and salivary glands, and systems, including nervous, musculoskeletal, genitourinary and vascular, and each of these symptoms may be at times correctly attributed to SS or incorrectly attributed to another disease. Other organs may be involved in more than 30% of cases and, occasionally, extra-glandular manifestations can occur early during the course of the disease [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Laryngological manifestations of Sjögren’s syndrome

Kamiński¹

2019

Reumatologia

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Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and a range of extra-glandular features. The most common and earliest symptoms are oral and ocular dryness. The aim of this study is to present the most common otolaryngological manifestations of SS, their pathomechanism and possible aetiology. The most common oral signs and symptoms are xerostomia, tooth decay, fungal infections, traumatic oral lesions, dysphagia, dysgeusia, and inflammation of the salivary glands. The salivary glands of SS patients are characterised by chronic inflammation. The presence of foci is thus a hallmark of SS. A biopsy can be taken from either the labial or the parotid salivary gland. The most significant complication of SS is the development of lymphoproliferative malignancy, which occurs in about 5% of SS patients. The ultrasonic greyscale scoring system, glandular volume measurement, and intraglandular power Doppler ultrasonography are specific ultrasound parameters of SS.

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Levels of EGF and VEGF in patients with primary and secondary Sjögren’s syndrome

Abstract: Background. Aberrant angiogenesis plays a role in the pathogenesis of Sjögren's syndrome (SS).

Cited by 9 publications

References 31 publications

Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

The unknown face of labial salivary glands. Labial salivary gland biopsy as a diagnostic tool

Laryngological manifestations of Sjögren’s syndrome

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