“…145 More recently, there has been a further attempt to characterize the GCF profile of a patient with gingivitis (i.e., a patient with a ( Table 3). [146][147][148][149][150][151][152][153][154][155] Overall, these studies indicate that the GCF proteomic profile of gingivitis subjects is qualitatively and quantitatively different from that of periodontal health; more specifically, a greater number of proteins have been found in gingivitis compared to periodontal health. 153 Moreover, the amount of some proteins (e.g., IL-1b, ALP, complement factors, MMP-9, fibronectin, lactotransferrin precursors, alpha-actinin) is higher in gingivitis compared to periodontal health, 147,153 while other proteins (e.g., cystatin-B, cystatin-S) are present in lower amounts in gingivitis.…”