Comparative Evaluation of Interleukin-35 Levels in Gingival Crevicular Fluid in Patients with Chronic Gingivitis and Chronic Periodontitis

Kaustubh, Thakare S; Manohar, Bhongade; Charde, Priti; Jaiswal, Priyanka; Kumar, Amit

doi:10.5005/jp-journals-10051-0089

Cited by 4 publications

(4 citation statements)

References 5 publications

(7 reference statements)

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“…In contrast, Koustubb et al, 2017 investigated IL-35 levels in the GCF of patients presenting with chronic gingivitis and periodontitis. Their results revealed elevated IL-35 levels in the chronic gingivitis group when compared to the chronic periodontitis group.…”

Section: Discussionmentioning

confidence: 99%

Estimating the salivary levels of IL-35 in smokers with periodontitis: A cross sectional study

Yuvashri,

Renuka Devi,

Esther Nalini

et al. 2024

The Saudi Dental Journal

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Section: Discussionmentioning

confidence: 99%

Estimating the salivary levels of IL-35 in smokers with periodontitis: A cross sectional study

Yuvashri,

Renuka Devi,

Esther Nalini

et al. 2024

The Saudi Dental Journal

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“…A study by the same authors evaluated and compared the levels of IL-35 in GCF in patients with chronic gingivitis and chronic periodontitis. The GCF IL-35 levels were significantly higher in the chronic gingivitis group than in the chronic periodontitis group; therefore, they concluded that the levels of IL-35 decrease with an increase in the inflammatory status; thus, it might play a role in controlling gingival inflammation and maintaining periodontal health [ 40 ]. We supposed that the high level of IL-35 in healthy sulcus confirms its anti-inflammatory role via interaction with the host mechanisms to maintain periodontal health; however, its low level in the periodontitis group is due to the active process of inflammatory reactions.…”

Section: Discussionmentioning

confidence: 99%

IL-39 and IL-35 gingival crevicular fluid levels in diabetic patients with generalized periodontitis

Hassan,

Abdelkawy,

Shaker

et al. 2024

Clin Oral Invest

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Objectives This research was performed to investigate if there is a role for IL-39 in immunopathogenesis of both systemically healthy and diabetic periodontitis patients. Additionally, to explore if we can consider IL-39 and IL-35 as biomarkers for periodontitis activity. Materials and methods A total of 38 periodontitis patients and 19 control volunteers were included in our study. The periodontitis patients were divided equally into (Group I), 19 patients with stage III grade C periodontitis with diabetes mellitus and (Group II), 19 patients with stage III grade B periodontitis and systemically healthy. Gingival crevicular fluid levels of each interleukin were measured pre- and postoperatively for all periodontitis patients as well as control subjects using ELISA. Results Our study results showed that the highest level for IL-39 was in diabetic periodontitis patients that decreased significantly postoperatively. However, the highest level for IL-35 was revealed in control group while the lowest value was registered in diabetic periodontitis patients and statistically increased after periodontal treatment. Conclusions Based on the results of our research, both investigated biomarkers may have a potent role in pathogenesis of periodontitis. Clinical relevance We could consider both interleukins as accurate diagnostic markers for periodontitis patients, regardless of diabetes mellitus association, as well as promising markers that can aid in the prevention and treatment of periodontitis patients worldwide.

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“…Kalburgi et al [ 155 ] were the first researchers that compared IL-35 levels in the gingival tissues of healthy controls and patients with chronic and aggressive periodontitis. The results show that IL-35 mRNA was expressed in the gingival tissues of all the three groups, but patients with chronic periodontal disease exhibited the highest IL-35 expression [ 156 ].…”

Section: Cytokines Associated With Periodontal Diseasementioning

confidence: 99%

“…It was found that the GCF and serum levels of both cytokines were elevated in CP patients [ 154 ]. A recent research study by Kaustubh et al has demonstrated the suppressive role of IL-35 in gingival inflammation and in maintaining periodontal health [ 156 ]. Furthermore, Raj et al indicated that IL-35 concentrations were increased in GCF in patients with CP [ 153 ].…”

Section: Cytokines Associated With Periodontal Diseasementioning

confidence: 99%

Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease

Kozak

Dąbrowska-Żamojcin

Mazurek−Mochol

et al. 2020

JCM

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Periodontal disease (PD) is a chronic inflammatory disease caused by the accumulation of bacterial plaque biofilm on the teeth and the host immune responses. PD pathogenesis is complex and includes genetic, environmental, and autoimmune factors. Numerous studies have suggested that the connection of genetic and environmental factors induces the disease process leading to a response by both T cells and B cells and the increased synthesis of pro-inflammatory mediators such as cytokines. Many studies have shown that pro-inflammatory cytokines play a significant role in the pathogenesis of PD. The studies have also indicated that single nucleotide polymorphisms (SNPs) in cytokine genes may be associated with risk and severity of PD. In this narrative review, we discuss the role of selected cytokines and their gene polymorphisms in the pathogenesis of periodontal disease.

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Comparative Evaluation of Interleukin-35 Levels in Gingival Crevicular Fluid in Patients with Chronic Gingivitis and Chronic Periodontitis

Cited by 4 publications

References 5 publications

Estimating the salivary levels of IL-35 in smokers with periodontitis: A cross sectional study

Estimating the salivary levels of IL-35 in smokers with periodontitis: A cross sectional study

IL-39 and IL-35 gingival crevicular fluid levels in diabetic patients with generalized periodontitis

Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease

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