Level of Education as a Risk Factor for Extensive Prevalence of Cervical Intervertebral Disc Degenerative Changes and Chronic Neck Pain

Markotić, Vedran; Zubac, Damir; Miljko, Miro; Šimić, Goran; Zalihić, Amra; Bogdan, Gojko; Radančević, Dorijan; Šimić, Ana Dugandžić; Mašković, Josip

doi:10.21101/cejph.a4897

Cited by 15 publications

(14 citation statements)

References 16 publications

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“…circRNAs that exhibited significantly lower levels in the degenerative group might have a protective effect on disc degeneration; thus, 15 circRNAs with decreased expression in the heat map were selected. To verify the heat map results, patients with fractures were selected as the control group, and three patients with different degrees of lesions were selected according to the Pfirrmann classification 23 . These samples were then analyzed using real-time (RT) quantitative polymerase chain reaction (qPCR), and the expression level of hsa_circ_0035875 was found to decrease with increasing lesion severity (Fig.…”

Section: Resultsmentioning

confidence: 99%

circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3

et al. 2021

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The abnormal expression of circular RNAs (circRNAs) is associated with numerous human diseases. This study investigated the mechanism by which circRNA acts as competitive endogenous RNA in the regulation of degenerative intervertebral disc disease (IVDD). Decreased expression of circSPG21 was detected in degenerated nucleus pulposus cells (NPCs), the function of circSPG21 in NPCs was explored and verified, and the downstream target of circSPG21 was investigated. The interaction between circSPG21 and miR-1197 and its target gene (ATP1B3) was studied by online database prediction and molecular biological verification. Finally, the circSPG21/miR-1197/ATP1B3 axis was verified in the mouse tail-looping model. The expression of circSPG21 in the nucleus pulposus in IVDD was directly related to an imbalance of anabolic and catabolic factors, which affected cell senescence. circSPG21 was found to play a role in human NPCs by acting as a sponge of miR-1197 and thereby affecting ATP1B3. The regulation of circSPG21 provides a potentially effective therapeutic strategy for IVDD.

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Section: Resultsmentioning

confidence: 99%

circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3

et al. 2021

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“…Those image-based classification focuses on the imaging characteristics of the intervertebral disc, such as the signal intensity of the nucleus and annulus, the nucleus structure, and the disc height. Markotić et al [ 11 ] applied Pfirrmann grades to evaluate CDD in 112 patients, and the results showed that a higher level of education was a risk factor leading to CDD. Also, Chen et al [ 12 ] used the Miyazaki grades to demonstrate that cigarette smoking could accelerate the process of CDD, leading to more severe neck-shoulder pain.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the correlation between clinical and radiological outcomes in patients suffering from mild to moderate cervical spine dysfunction symptoms: a prospective study

et al. 2022

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Background Neck pain and cervical disc degeneration (CDD) are common findings. Valid data on correlation between clinical scores and radiological grade of CDD in patients with mild to moderate clinical disability are not available. The study has been designed to investigate the correlation between clinical and radiological outcomes in these patients. Methods A cohort of 150 patients who suffered from mild to moderate cervical spine dysfunction symptoms from September 2020 to May 2021 was enrolled. We evaluated functional status using Japanese Orthopaedic Association scores (JOA), the visual analog scale, and the Neck Disability Index. We assessed the CDD with magnetic resonance imaging-based grading systems. We analyzed relationships between radiological grades of CDD and clinical symptoms along with demographic data. Results One hundred thirteen patients [mean age 44.78, 78 (69%) females] were finally included. CDD occurred most at the C5–C6 level, with 56.93% of higher grade III from Miyazaki. The grades of Miyazaki (P < 0.05) and the scores of Nakashima (P < 0.05) were positively correlated with the duration of symptoms, and the severity of the CDD increased with aging (P < 0.01). Moreover, we correlated patients’ JOA scores with the current scoring and grading systems, especially the grades of Miyazaki (P < 0.01) and the scores of Nakashima (P < 0.01). Conclusion Increasing grades of CDD paralleled decreasing JOA scores in the population studied.

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“…It was originally developed for the grading of lumbar disk degeneration. Nevertheless, it has become the most commonly used classification system in the literature even for cervical spine degeneration [8][9][10][11] . Other authors were able to demonstrate nearly perfect reliability for the assessment of cervical disk degeneration 12 .…”

Section: Introductionmentioning

confidence: 99%

How Should We Grade Cervical Disk Degeneration? A Comparison of Two Popular Classification Systems

Urbanschitz

Bensler

Merat

et al. 2021

Spine Surg Relat Res

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Introduction Despite being originally developed for the evaluation of lumbar disk degeneration, the Pfirrmann classification has emerged as the most popular classification system for cervical disk degeneration. However, with the Suzuki classification, a new classification system that is specifically tailored for the evaluation of cervical disk disease was introduced. In this study, we aim to evaluate differences in inter- and intraobserver reliability of both classifications in a head-to-head comparison. Methods In total, we have evaluated 120 cervical disks within 40 patients via magnetic resonance imaging according to the Pfirrmann and Suzuki classification. The degree of disk degeneration was evaluated by two independent musculoskeletal radiologists. After 6 months, the classification was reassessed to evaluate the intraobserver reliability. The inter- and intraobserver reliabilities were then calculated using Cohen's kappa. Results The inter- and intraobserver reliability provided a significant agreement between all ratings in Pfirrmann as well as the Suzuki classification (p>0.001). The interobserver reliability was determined to be fair in both the Suzuki classification (κ=0.290) and the Pfirrmann classification (κ=0.265). The intraobserver reliability was substantial in the Suzuki classification (κ=0.798), while it was almost perfect in the Pfirrmann classification (κ=0.858). Conclusions Although not designed for the evaluation of cervical disk degeneration, the Pfirrmann classification yielded equal inter- and higher intraobserver reliability. Both classification systems are viable options for the grading of cervical disk degeneration. While the Pfirrmann classification has the advantage of being better established, the Suzuki classification may be clinically superior due to a better representation of cervical disk degeneration and the consideration of disk bulging for the classification of cervical disk degeneration.

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Level of Education as a Risk Factor for Extensive Prevalence of Cervical Intervertebral Disc Degenerative Changes and Chronic Neck Pain

Cited by 15 publications

References 16 publications

circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3

circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3

Assessment of the correlation between clinical and radiological outcomes in patients suffering from mild to moderate cervical spine dysfunction symptoms: a prospective study

How Should We Grade Cervical Disk Degeneration? A Comparison of Two Popular Classification Systems

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