Level of Cytokine Interleukin-6 and Interleukin 1-� on Infectious Rat Model Treated with Etlingera elatior (Jack) R.M. Smith Fruit Extract as Immunomodulator

Abstract

Etlingera elatior (Jack) R.M Smith or locally in Southeast Sulawesi known as Wualae fruit has activity as an immunomodulator by increasing phagocytosis activity. Prior studies have been conducted to observe the effect of E. elatior as an immunomodulator, thus further study is needed to observe the production of cytokines such as IL-1� and IL-6 which are responsible for the immune responses. Etlingera elatior fruit macerated with 96% ethanol for three days and produced a total of �74.6 g concentrated extract. Experimental animals used were divided into four groups (n=4) and treated orally once a day for seven days as follows: group I (0.5% Na CMC); group II (Stimuno�); group III (E. elatior fruit extract dose of 300 mg/kg BW); and group IV (E. elatior fruit extract dose of 400 mg/kg BW). On the eight-day, animals were infected with Staphylococcus aureus intraperitoneally and left for an hour. Thereafter, blood was collected and assayed using ELISA Kit (Elabscience rat IL-1� and Elabscience rat IL-6). Results demonstrated that group IV increased levels of IL-1� and group III and IV increased level of IL-6 (p<0.05). Increased levels of IL-1� and IL-6 are associated with phagocytosis in the immune response. In conclusion, E. elatior fruit extract at doses of 300 and 400 mg/kg BW increases levels of IL-1� and IL-6.

Effect of Hayani Date (Phoenix dactylifera L) Peels on Blood Sugar, Blood Lipids, Liver and Kidney Functions, and Inflammation in Diabetic Rats

“…-Determination of serum interleukin-1 beta (IL-1β) level was measured using the ELISA Kit (Elabscience® rat IL-1β and Elabscience® rat IL-6) as mentioned by Fristiohady et al [34].…”

Suppression of Proinflammatory Cytokines by Etlingera alba (A.D.) Poulsen Rhizome Extract and Its Antibacterial Properties

“…Etlingera elatior has activity as an antioxidant, anti-inflammatory, immunomodulatory, anticancer, and antibacterial. It also provides nephroprotective and hepatoprotective activity [6][7][8][9][10][11]. E. brevilabrum leaves and stem are reported to decrease cholesterol levels [12].…”

Activity Prediction of Bioactive Compounds Contained in Etlingera elatior Against the SARS-CoV-2 Main Protease: An In Silico Approach

“…Etlingera elatior (known as Wualae in Tolakinese) is a medicinal plant from Indonesia which are found mainly on the island of Sulawesi, particularly Southeast Sulawesi (Fristiohady et al, 2020;Fristiohady et al, 2019). Etlingera elatior contains various types of compounds, including flavonoids and steroids with various pharmacological activities, one of them as antimicrobial (Sahidin et al, 2019;Wahyuni et al, 2018).…”