Leukocytosis in obese individuals: possible link in patients with unexplained persistent neutrophilia

Herishanu, Yair; Rogowski, Ori; Polliack, Aaron; Marilus, Raphael

doi:10.1111/j.1600-0609.2006.00658.x

Cited by 135 publications

(114 citation statements)

References 26 publications

(28 reference statements)

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“…In support of previous findings, the positive associations between the number of cells and obesity have been reported in a number of cross sectional studies [15,21]. For example, Herishanu et al study [22] found that from among several factors responsible for persistent leukocytosis, such as smoking, myeloproliferative and lymphoproliferative disease, obesity would be the only identified cause.…”

Section: Discussionsupporting

confidence: 66%

Association Between Obesity, White Blood Cell and Platelet Count

Jamshidi

Seif

2017

Zahedan J Res Med Sci

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Background: Cardiovascular disease is resulted from malfunctioning's of heart as well as blood vessels. More than two decades ago it was noted that the number of white blood cells can be an indicated of the existence of such disease. Platelet activation and aggregation are among the include processes. That are considered in pathophysiology of a coronary heart disease. However there seems to be a paucity of research on platelet count in patients suffering from obesity. Moreover although previous studies have indicated a positive correlation between platelet and white blood cells. Counts and mortality from coronary heath disease, how this might correlate with obesity is an issue still in need of more attention. Objectives: The present study was designed to evaluate platelet count and white blood cell count in those patients who suffer from obesity as compared with control subjects who were not obese. Methods: In this cross-sectional study, there were a total of 1024 Iranian subjects living in Hamedan include, staff of Islamic Azad University of Hamedan and subjects who referred to Ekbatan hospital in Hamedan during the period of 6 months randomly and staff of Islamic Azad University of Hamedan. The absence of infectious disease was confirmed by a general practitioner. Finally, the samples included 486 subjects, 254 male, and 232were females. Body mass index was calculated. Waist circumference in the Iranian subjects, at least in men 89 (cm) and women 91 (cm) was considered. White blood cell and platelet count was measured. T-test and Pearson's correlation were run to analyze the collected data through SPSS software version 16.

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Section: Discussionsupporting

confidence: 66%

Association Between Obesity, White Blood Cell and Platelet Count

Jamshidi

Seif

2017

Zahedan J Res Med Sci

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“…There are many conditions in which a high inflammatory state has been reported to be associated with AR dilatation,33, 34 thus the correlation between ARD and markers of inflammation, such as neutrophil percentage in the present study, was not a surprise 35. Our understanding of the role of the neutrophil in inflammation has changed fundamentally in recent years.…”

Section: Discussionmentioning

confidence: 46%

Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study

Simone

Roman

Marco

et al. 2015

JAHA

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BackgroundWe evaluated the relationship of aortic root dimension (ARD) with flow output and both peripheral and central blood pressure, using multivariable equations predicting ideal sex‐specific ARD at a given age and body height.Methods and ResultsWe measured echocardiographic diastolic ARD at the sinuses of Valsalva in 3160 adults (aged 42±16 years, 61% women) from the fourth examination of the Strong Heart Study who were free of prevalent coronary heart disease, and we compared measured data with the theoretical predicted value to calculate a z score. Central blood pressure was estimated by applanation tonometry of the radial artery in 2319 participants. ARD z scores were divided into tertiles representing small, normal, and large ARD. Participants with large ARD exhibited greater prevalence of central obesity and higher levels of inflammatory markers and lipids (0.05

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“…Obesity is associated with increased plasmatic concentration of several proinflammatory mediators and of calcitonin gene-related protein. 38,39 Furthermore, relative to normal weight, obese migraineurs have attacks of increased frequency and severity, 29 which may explain the higher prevalence of CA in obese individuals. Of note is the age-related decrease in CA.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and characteristics of allodynia in headache sufferers

et al. 2008

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Objective: The authors estimated the prevalence and severity of cutaneous allodynia (CA) in individuals with primary headaches from the general population. Methods:We mailed questionnaires to a random sample of 24,000 headache sufferers previously identified from the population. The questionnaire included the validated Allodynia Symptom Checklist (ASC) as well as measures of headache features, disability, and comorbidities. We modeled allodynia as an outcome using headache diagnosis, frequency and severity of headaches, and disability as predictor variables in logistic regression. Covariates included demographic variables, comorbidities, use of preventive medication, and use of opioids.Results: Complete surveys were returned by 16,573 individuals. The prevalence of CA of any severity (ASC score ≥3) varied with headache type. Prevalence was significantly higher in transformed migraine (TM, 68.3%) than in episodic migraine (63.2%, p < 0.01) and significantly elevated in both of these groups compared with probable migraine (42.6%), other chronic daily headaches (36.8%), and severe episodic tension-type headache (36.7%). The prevalence of severe CA (ASC score ≥9) was also highest in TM (28.5%) followed by migraine (20.4%), probable migraine (12.3%), other chronic daily headaches (6.2%), and severe episodic tension-type headache (5.1%). In the migraine and TM groups, prevalence of CA was higher in women and increased with disability score. Among migraineurs, CA increased with headache frequency and body mass index. In all groups, ASC scores were higher in individuals with major depression. Conclusions:Cutaneous allodynia (CA) is more common and more severe in transformed migraine and migraine than in other primary headaches. Among migraineurs, CA is associated with female sex, headache frequency, increased body mass index, disability, and depression.Central sensitization, an increased excitability of spinal and medullary dorsal horn neurons resulting from ongoing input from C-fiber nociceptors, may lead to cutaneous allodynia (CA), a neurologic condition characterized by pain elicited by ordinary nonnociceptive stimulation of the skin. 1,2 During migraine, facial CA is likely to be a clinical manifestation of sensitization at the level of the trigeminal nucleus caudalis. 3,4 In clinic-based studies, most migraineurs develop CA during the course of an attack. 5-8 In migraine, CA has been proposed as a predictor of poor response to triptan therapy 8 as well as a risk factor for disease progression. 9Address correspondence and reprint requests to Dr. Marcelo E. Bigal, Global Director, Scientific Affairs, Neuroscience, One Merck Drive, P.O. Box 100, Whitehouse Station, NJ 08889-0100 Marcelo_Bigal@merck.com. * Members of the AMPP Advisory Group are listed in the appendix. Here, we used the ASC-12 to assess the prevalence and severity of CA in subjects with various types of primary headaches in the general population. Because CA has been recently suggested as a risk factor for migraine progression, we hypothesized ...

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Leukocytosis in obese individuals: possible link in patients with unexplained persistent neutrophilia

Abstract: Obesity is recognized as a possible cause for reactive leukocytosis. Awareness of this 'obesity-associated leukocytosis' may help the clinician to avoid more extensive and unnecessary diagnostic work-up, particularly in similar obese subjects.

Cited by 135 publications

References 26 publications

Association Between Obesity, White Blood Cell and Platelet Count

Association Between Obesity, White Blood Cell and Platelet Count

Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study

Prevalence and characteristics of allodynia in headache sufferers

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