Association Between Obesity, White Blood Cell and Platelet Count

Abstract

Background: Cardiovascular disease is resulted from malfunctioning's of heart as well as blood vessels. More than two decades ago it was noted that the number of white blood cells can be an indicated of the existence of such disease. Platelet activation and aggregation are among the include processes. That are considered in pathophysiology of a coronary heart disease. However there seems to be a paucity of research on platelet count in patients suffering from obesity. Moreover although previous studies have indicated a positive correlation between platelet and white blood cells. Counts and mortality from coronary heath disease, how this might correlate with obesity is an issue still in need of more attention. Objectives: The present study was designed to evaluate platelet count and white blood cell count in those patients who suffer from obesity as compared with control subjects who were not obese. Methods: In this cross-sectional study, there were a total of 1024 Iranian subjects living in Hamedan include, staff of Islamic Azad University of Hamedan and subjects who referred to Ekbatan hospital in Hamedan during the period of 6 months randomly and staff of Islamic Azad University of Hamedan. The absence of infectious disease was confirmed by a general practitioner. Finally, the samples included 486 subjects, 254 male, and 232were females. Body mass index was calculated. Waist circumference in the Iranian subjects, at least in men 89 (cm) and women 91 (cm) was considered. White blood cell and platelet count was measured. T-test and Pearson's correlation were run to analyze the collected data through SPSS software version 16.

Association between Neutrophil-to-Lymphocyte Ratio with Abdominal Obesity and Healthy Eating Index in a Representative Older Spanish Population

“…In this way, chronic inflammation has emerged as one of the key physiological mechanisms that links obesity with different associated pathologies, such as diabetes, cardiovascular disease, cancer, and asthma; thus, it is important to determine the presence of inflammation in a population. In particular, obesity has been linked to high CRP levels [87][88][89] and changes in the leukocyte profile [90,91]. In addition, according to our results, in a study carried out in 26,016 middle-aged and older adults (>35 years old) with metabolic syndrome in Taiwan, obesity, high body fat, high WC or hip circumference, and high WHtR were significantly associated with increased odds ratios of high CRP and NLR [12].…”

Changes in leukocyte profile and C-reactive protein concentration in overweight and obese adolescents after reduction of body weight

“…A higher count of leukocytes is reported also in obese children with non-alcoholic fatty liver disease (NAFLD) [7] and type 2 diabetes [30], which increases the prevalence of metabolic syndrome [31]. Likewise, a chronic inflammatory process activates thrombogenic factors and leads to an increase in the platelet number in patients with excess fat mass [10, 12, 32], but this process has not been confirmed in our study. Differences in WBC, neutrophil, lymphocyte and platelet counts were not always found in other studies [33, 34].…”

“…Numerous studies have shown that changes in the leukocyte profile are associated with indices of excess adiposity [9, 10, 32, 35, 36]. In two cross-sectional studies including a representative sample of the Korean pediatric population and Italian overweight and obese children, the mean values of BMI, BMI z -score, waist circumference and WHtR increased along with the increase in WBC count quartile [37, 38].…”

The Difference in Serum Ferritin and Leukocyte Regarding Overweight and Obese South Korean Adults

“…In addition, factors affecting leukocyte were gender, obesity, overweight and weight change over the past year (weight gain). The study found a positive correlation between BMI and leukocyte in the obese group [24] and cross-sectional studies reported a positive association between obesity and leukocyte count [17]. The number of leukocyte in overweight and obesity was 1.06 times (95% CI= 0.9-1.2) and 1.11 times (95% CI= 0.9-1.3), respectively [14].…”