Leukemic Optic Nerve Infiltration Complicated by Retinal Artery and Vein Occlusions

Moisseiev, Elad; Ling, Jennifer; Morse, Lawrence S.

doi:10.1097/iae.0000000000001223

Cited by 7 publications

(6 citation statements)

References 2 publications

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“…This is probably explained by the comorbidity burden or common risk factors. Previous case reports suggesting an association between retinal vein thrombosis and hematological cancers could not be confirmed …”

Section: Discussionmentioning

confidence: 70%

“…Thus, venous thromboembolism in the lower extremities and the lungs are markers of cancer . Several case reports have suggested that retinal vein thrombosis may also be a clinical sign of cancer, especially hematological cancers, but firm epidemiological evidence is lacking. Putative mechanisms involve direct neoplastic infiltration leading to impaired drainage and obstruction of the retinal veins, as well as dehydration and hyperviscosity caused by the cancer .…”

Section: Introductionmentioning

confidence: 99%

“…Several case reports have suggested that retinal vein thrombosis may also be a clinical sign of cancer, especially hematological cancers, but firm epidemiological evidence is lacking. Putative mechanisms involve direct neoplastic infiltration leading to impaired drainage and obstruction of the retinal veins, as well as dehydration and hyperviscosity caused by the cancer . To investigate these suppositions, we examined the risk of cancer following a retinal vein thrombosis compared with cancer risk in the general population.…”

Section: Introductionmentioning

confidence: 99%

“…involve direct neoplastic infiltration leading to impaired drainage and obstruction of the retinal veins, as well as dehydration and hyperviscosity caused by the cancer. [1][2][3]16,18 To investigate these suppositions, we examined the risk of cancer following a retinal vein thrombosis compared with cancer risk in the general population.…”

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confidence: 99%

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Retinal vein thrombosis and risk of occult cancer: A nationwide cohort study

Hansen

Veres

Prandoni³

et al. 2018

Cancer Medicine

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BackgroundRetinal vein thrombosis has in case reports been reported a clinical sign of cancer, especially hematological cancer. However, it is unclear whether retinal vein thrombosis is a marker of underlying cancer, as is the case for deep venous thrombosis and pulmonary embolism. We investigated the risk of occult cancer in patients with retinal vein thrombosis.MethodsA nationwide population‐based cohort study in Denmark on all patients diagnosed with a retinal vein thrombosis during 1994 and 2013. The main outcome measures were any cancer and site‐specific cancers <6 months, 6‐12 months, and 5 years following a retinal vein thrombosis diagnosis, as registered in the Danish Cancer Registry and the National Pathology Registry. We calculated the absolute cancer risk and computed standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) for cancer within <6 months, 6‐12 months, and 5 years following a retinal vein thrombosis diagnosis.ResultsAmong 9589 patients with retinal vein thrombosis, we observed 1514 cancer cases. The risk of any cancer was 1.2% <6 months and 28.8% after 5 years. The <6 months SIR was 1.20 (95% CI 0.99‐1.44), 6‐12 months SIR was 1.15 (95% CI 0.94‐1.39), and the 5 years’ SIR was 1.08 (95% CI 1.03‐1.14). Stratification by age, gender, calendar year, and Charlson Comorbidity Index score did not change overall cancer risk estimates.ConclusionRetinal vein thrombosis was not an important clinical marker for occult cancer. An extensive diagnostic cancer workup does not appear warranted for retinal vein thrombosis patients.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Retinal vein thrombosis and risk of occult cancer: A nationwide cohort study

Hansen

Veres

Prandoni³

et al. 2018

Cancer Medicine

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“…An alternative explanation is that hyperviscocity may have contributed to both retinal and optic disc ischaemia, leading to BRAO and optic disc oedema. Although there have been rare case reports of optic disc infiltration with simultaneous retinal artery occlusion in acute lymphoblastic leukaemia,3 to our knowledge, this is the first report of this as a presenting sign of CLL.…”

Section: Descriptionmentioning

confidence: 63%