Retinal vein thrombosis and risk of occult cancer: A nationwide cohort study

Hansen, Anette Tarp; Veres, Katalin; Prandoni, Paolo; Adelborg, Kasper; Sørensen, Henrik Toft

doi:10.1002/cam4.1803

Cited by 5 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…34 The diagnosis of retinal vein thrombosis in the DNPR is assumed to have high validity because almost all patients are diagnosed at ophthalmologic departments. 35 While the splanchnic vein thrombosis and cerebral vein thrombosis diagnoses in the DNPR have not yet been validated, most splanchnic vein thrombosis diagnoses are based on an ultrasound examination or a computed tomography scan, 36 and it is unlikely that the validity of the cerebral vein thrombosis diagnosis diverges greatly from that of other VTE diagnoses.…”

Section: Discussionmentioning

confidence: 99%

Venous Thromboembolism in Denmark: Seasonality in Occurrence and Mortality

Skajaa

Horváth‐Puhó

Adelborg

et al. 2019

TH Open

Self Cite

View full text Add to dashboard Cite

Background Many cardiovascular conditions exhibit seasonality in occurrence and mortality, but little is known about the seasonality of venous thromboembolism. Methods Using Danish registries, we identified all patients with deep vein thrombosis, pulmonary embolism, splanchnic vein thrombosis, cerebral vein thrombosis, and retinal vein thrombosis during 1977–2016. We tallied monthly deaths occurring within 90 days of the venous thromboembolism diagnosis. We estimated peak-to-trough ratios and timing of the peak of both diagnoses and deaths summed over all years of the study period. The departure from 1.0 of the peak-to-trough ratio measures the intensity of any seasonal pattern. Results We estimated a peak-to-trough ratio of 1.09 (95% confidence interval: 1.07–1.11) for deep vein thrombosis and 1.22 (1.19–1.24) for pulmonary embolism occurrence. The peak-to-trough ratios for splanchnic vein thrombosis, cerebral vein thrombosis, and retinal vein thrombosis occurrence were 1.10 (1.01–1.20), 1.19 (1.00–1.40), and 1.12 (1.07–1.17), respectively. The occurrence of all conditions peaked during winter or fall. In time trend analyses, the peak-to-trough ratio increased considerably for splanchnic vein thrombosis, cerebral vein thrombosis, and retinal vein thrombosis occurrence. In associated mortality, the peak-to-trough ratio for deep vein thrombosis was larger (1.15, 1.07–1.23) than that for pulmonary embolism (1.04, 1.01–1.08). Discussion Excess winter risks were modest, but more marked for pulmonary embolism occurrence than for deep vein thrombosis occurrence. The seasonal pattern intensified throughout the study period for splanchnic vein thrombosis, cerebral vein thrombosis, and retinal vein thrombosis. The winter peak in mortality following pulmonary embolism was smaller than that for deep vein thrombosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Venous Thromboembolism in Denmark: Seasonality in Occurrence and Mortality

Skajaa

Horváth‐Puhó

Adelborg

et al. 2019

TH Open

Self Cite

View full text Add to dashboard Cite

show abstract

“…Extensive diagnostic cancer screening is also not warranted in patients with RVO, who do not have an increased risk of cancer, as shown in a Danish nationwide populationbased cohort study. 75…”

Section: Cancer Screeningmentioning

confidence: 99%

Treatment of unusual thrombotic manifestations

Abbattista¹,

Capecchi

Martinelli

2020

Blood

View full text Add to dashboard Cite

Venous thrombosis rarely occurs at unusual sites such as cerebral, splanchnic, upper-extremity, renal, ovarian, or retinal veins. Clinical features, symptoms, and risk factors of rare thrombotic manifestations are heterogeneous and in large part differ from those typical of the commonest manifestations of venous thrombosis at the lower extremities. The therapeutic approach also varies widely according to the affected site, whether cerebral, abdominal, or extraabdominal. To date, anticoagulant therapy for thrombosis at unusual sites is generally accepted, but the optimal therapeutic approach remains challenging. This review is focused on the treatment of unusual thrombotic manifestations as reported in the most recent guidelines and according to the updated scientific literature.

show abstract

“…3 The mechanisms proposed for association of malignancy with RVO are direct neoplastic infiltration of the tumour leading to impaired drainage and obstruction of the retinal veins, as well as dehydration and hyperviscosity caused by the cancer. 4 However, study by Hansen et al 4 revealed no association of occult cancer-associated hypercoagulability with venous thromboembolism and retinal vein thrombosis.…”

mentioning

confidence: 99%

Branch retinal vein occlusion as the presenting feature of germ cell tumour

Tripathi

Sahay

Tripathi

2021

Canadian Journal of Ophthalmology

View full text Add to dashboard Cite

Branch retinal vein occlusion as the presenting feature of germ cell tumour Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy. RVO stands as one of the common causes of visual morbidity and blindness in the elderly population. RVO can be classified into central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) based on the site of vascular occlusion. The incidence of BRVO is generally higher than the incidence of CRVO. Systemic hypertension, hyperlipidemia, and increased body mass index are important risk factors for BRVO in young patients, 1 similar to older population. Recent studies of RVO and thrombophilic factors showed that only hyperhomocysteinemia and anticardiolipin antibodies play a pivotal role in the pathogenesis of RVO. Testicular cancer, although rare, is the most common malignancy in men aged 20À34 years, and 95% of malignant tumours arising in the testes are germ cell tumours (GCTs), and seminomas are the most common type of testicular GCTs. The typical presentation in testicular seminoma is a painless testicular lump with duration of several days to months, and the patient may be subfertile or may present with a hydrocele. Scrotal ultrasonography may identify a nonpalpable testis tumour. Several placental and fetal proteins are secreted by these tumours. Two of these, human chorionic gonadotropin and alpha-fetoprotein, have been shown to be useful for the diagnosis of these GCTs .These tumour markers are also used to assess the disease activity during therapy and for detection of recurrences. Few cases of vascular thromboembolism have been reported in GCT. 2 The vascular events are either sequelae of chemotherapy and radiotherapy used for treatment or due to occult metastasis. No case of BRVO/RVO has been reported in GCTs to the best of our knowledge. We report an unusual association of BRVO and GCT in a 25-year-old patient. A 25-year-old man presented to our outpatient department with complaints of sudden, painless diminution of vision in the right eye for 2 days. There was no significant ocular or medical history. His family history was not significant. On ocular examination, his uncorrected distance visual acuity was 6/18 in the right eye and 6/60 in the left on Snellen's chart. The best-corrected visual acuity was 6/18 (right eye) with +0.50 DS/À1.00 DC at 20°and 6/6 (left eye) with 0.00 DS/À2.50 DC at 160°. The near visual acuity was N6 in both eyes. Slit-lamp examination was unremarkable. Fundus examination of right eye revealed flame hemorrhages, dot-and-blot hemorrhages, cotton wool spots, hard

show abstract

Retinal vein thrombosis and risk of occult cancer: A nationwide cohort study

Cited by 5 publications

References 28 publications

Venous Thromboembolism in Denmark: Seasonality in Occurrence and Mortality

Venous Thromboembolism in Denmark: Seasonality in Occurrence and Mortality

Treatment of unusual thrombotic manifestations

Branch retinal vein occlusion as the presenting feature of germ cell tumour

Contact Info

Product

Resources

About