Lethal Invasive Cestodiasis in Immunosuppressed Patients

Olson, Peter D.; Yoder, Kristine E.; L-G, Luis F Fajardo; Marty, Aileen M.; Pas, Simone van de; Olivier, Claudia; Relman, David A.

doi:10.1086/375357

Cited by 51 publications

(43 citation statements)

References 10 publications

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“…Humans have been considered to be susceptible to H. nana (1). In fact, in some parts of the world, especially in tropical regions, human infection is prevalent, particularly in children (13,14) and immunodeficient patients (15,16 (18). In our study, the detection of eggs of H. nana in the feces of Syrian hamster was quite remarkable for public health, because these rodents are in close contact with children and can move freely on their desk and bed.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Intestinal Parasites in Hamsters and Rabbits in Some Pet Shops of Turkey

Sürsal

Gökpınar²,

Yıldız³

2014

urkiyeParazitolDerg

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Objective: In this study, we aimed to determine the parasite species carried by hamsters and rabbits purchased from some commercial pet shops in Turkey. Methods: For this purpose, the fecal samples of clinically healthy Syrian hamsters, dwarf hamsters, and crossbred rabbits were collected from 22 pet shops randomly selected in Ankara and Kirikkale provinces, located in Central Anatolia Region of Turkey. The fecal samples were examined with centrifuge flotation technique using saturated salt solution. Results: Parasitic infection rate was 57.5% in dwarf hamsters, 54.9% in Syrian hamsters, and 56.3% in crossbreed rabbits. Trichurid eggs were the most prevalent parasite in the feces of Syrians hamsters (28.1%). The other parasites of Syrian hamsters were as follows: Eimeria spp. oocysts (15.4%) and the eggs of H. nana (11.2%), Syphacia spp. (11%). and Aspiculuris spp. (5.6 %). Only trichurid eggs were observed in the fecal samples of dwarf hamsters (51.5%). Oocysts of Eimeria spp. (52.7%) and the eggs of P. ambiguus (3.6%) were detected in the feces of rabbits. Conclusion: Within the scope of this study, the detection of H. nana eggs, a zoonotic parasite, in the feces of Syrian hamster was quite remarkable for public health. (Turkiye Parazitol Derg 2014; 38: 102-5) (Turkiye Parazitol Derg 2014; 38: 102-5) Anahtar Sözcükler: Parazit, petshop, tavşan, hamster, dışkı muayenesi

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Section: Discussionmentioning

confidence: 99%

Prevalence of Intestinal Parasites in Hamsters and Rabbits in Some Pet Shops of Turkey

Sürsal

Gökpınar²,

Yıldız³

2014

urkiyeParazitolDerg

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“…Unique to R. microstoma and R. fraterna is the capability of reproducing and completing their life cycles without the need of an intermediate host [2]. However, an intermediate host is necessary to complete the life cycle of H. diminuta .…”

Section: Discussionmentioning

confidence: 99%

“…230 and 620 species of hymenolepidids parasitizing mammals and birds, respectively. Some of the hymenolepidid species of rodents are of health interest, since they are zoonotic and can cause severe diseases in immunosuppressed individuals [2-4]. …”

Section: Introductionmentioning

confidence: 99%

Distribution and genetic variation of hymenolepidid cestodes in murid rodents on the Canary Islands (Spain)

Foronda¹,

López-González²,

Hernández³

et al. 2011

Parasites Vectors

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BackgroundIn the Canary Islands there are no previous data about tapeworms (Cestoda) of rodents. In order to identify the hymenolepidid species present in these hosts, a survey of 1,017 murine (349 Rattus rattus, 13 Rattus norvegicus and 655 Mus musculus domesticus) was carried out in the whole Archipelago. Molecular studies based on nuclear ITS1 and mitochondrial COI loci were performed to confirm the identifications and to analyse the levels of genetic variation and differentiation.ResultsThree species of hymenolepidids were identified: Hymenolepis diminuta, Rodentolepis microstoma and Rodentolepis fraterna. Hymenolepis diminuta (in rats) and R. microstoma (in mice) showed a widespread distribution in the Archipelago, and R. fraterna was the least spread species, appearing only on five of the islands. The hymenolepidids found on Fuerteventura, Lanzarote and La Graciosa were restricted to one area. The COI network of H. diminuta showed that the haplotypes from Lanzarote and Fuerteventura are the most distant with respect to the other islands, but clearly related among them.ConclusionsFounder effects and biotic and abiotic factors could have played important role in the presence/absence of the hymenolepidid species in determined locations. The haplotypes from the eastern islands (Fuerteventura and Lanzarote) seem to have shared an ancestral haplotype very distant from the most frequent one that was found in the rest of the islands. Two colonization events or a single event with subsequent isolation and reduced gene flow between western-central and eastern islands, have taken place in the Archipelago. The three tapeworms detected are zoonotic species, and their presence among rodents from this Archipelago suggests a potential health risk to human via environmental contamination in high risk areas. However, the relatively low prevalence of infestations detected and the focal distribution of some of these species on certain islands reduce the general transmission risk to human.

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“…Generally, human cases of hymenolepiasis mostly appear asymptomatic; however, humans infected with these parasites are sometimes responsible for mild clinical symptoms, mainly including diarrhea, abdominal pain, anorexia, and vague gastrointestinal manifestations [5,6]. Most seriously, infection of H. nana and H. diminuta ultimately can cause severe diseases, even life threatening conditions in immunosuppressed individuals with HIV [7,8]. …”

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confidence: 99%

“…Clinically, hymenolepiasis is often neglected or underreported due to more asymptomatic infections in humans. However, 2 death cases caused by H. nana in immunosuppressed individuals highlight the severity of hymenolepiasis [7,8]. The importance and necessity to carry out epidemiological investigations of human hymenolepiasis is undeniable in the future, including assessment of transmission dynamic and the burden of human hymenolepiasis attributable to zoonotic transmission.…”

mentioning

confidence: 99%

Prevalence of Hymenolepis nana and H. diminuta from Brown Rats (Rattus norvegicus) in Heilongjiang Province, China

Yang¹,

Zhao

Zhang³

et al. 2017

Korean J Parasitol

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Hymenolepis nana and Hymenolepis diminuta are globally widespread zoonotic cestodes. Rodents are the main reservoir host of these cestodes. Brown rats (Rattus norvegicus) are the best known and most common rats, and usually live wherever humans live, especially in less than desirable hygiene conditions. Due to the little information of the 2 hymenolepidid species in brown rats in China, the aim of this study was to understand the prevalence and genetic characterization of H. nana and H. diminuta in brown rats in Heilongjiang Province, China. Total 114 fecal samples were collected from brown rats in Heilongjiang Province. All the samples were subjected to morphological examinations by microscopy and genetic analysis by PCR amplification of the mitochondrial cytochrome c oxidase subunit 1 (COX1) gene and the internal transcribed spacer 2 (ITS2) region of the nuclear ribosomal RNA gene. In total, 6.1% (7/114) and 14.9% (17/114) of samples were positive for H. nana and H. diminuta, respectively. Among them, 7 and 3 H. nana isolates were successfully amplified and sequenced at the COX1 and ITS2 loci, respectively. No nucleotide variations were found among H. nana isolates at either of the 2 loci. Seventeen H. diminuta isolates produced 2 different COX1 sequences while 7 ITS2 sequences obtained were identical to each other. The present results of H. nana and H. diminuta infections in brown rats implied the risk of zoonotic transmission of hymenolepiasis in China. These molecular data will be helpful to deeply study intra-specific variations within Hymenolepis cestodes in the future.

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Lethal Invasive Cestodiasis in Immunosuppressed Patients

Cited by 51 publications

References 10 publications

Prevalence of Intestinal Parasites in Hamsters and Rabbits in Some Pet Shops of Turkey

Prevalence of Intestinal Parasites in Hamsters and Rabbits in Some Pet Shops of Turkey

Distribution and genetic variation of hymenolepidid cestodes in murid rodents on the Canary Islands (Spain)

Prevalence of Hymenolepis nana and H. diminuta from Brown Rats (Rattus norvegicus) in Heilongjiang Province, China

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