Lessons Learned from the First Decade of Laser-Assisted Drug Delivery

Searle, Tamara; Ali, Faisal; Al‐Niaimi, Firas

doi:10.1007/s13555-020-00478-5

Cited by 22 publications

(8 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[16] It has also been suggested that because of the barrier function of the stratum corneum, penetration of anesthetic into deeper skin layers is limited and pain relief is usually incomplete with surface anesthesia. [17] However, several studies have reported that laser treatment of keloid scars under surface anesthesia is mild and enough to achieve patient satisfaction. [18,19] The majority of patients in this study had tolerable pain, probably due to the adequate duration of surface anesthesia and the sealant package, which increased the temperature and hydration of the stratum corneum, and lidocaine cream is su ciently absorbed into the subcutis, blocking injurious transmission and achieving signi cant anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Effect of general and surface anesthesia on micro-plasma radiofrequency of hypertrophic scar: A retrospective cohort study

Meng

Qian

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Although micro-plasma radiofrequency (MPR) treatment has a significant effect on scars, patients require anesthesia to relieve the significant discomfort it produces. Whether anesthesia impacts efficacy is unclear. Objective To evaluate the effect of different anesthesia on MPR for hypertrophic scars. Methods A retrospective cohort study involving 101 people was conducted to investigate the effectiveness and safety of general and topical anesthetics for the treatment of MPR scars. The primary measures of outcome were the Vancouver Scar Scale (VSS) scores before the first treatment and six months after the last treatment, as well as the Visual Analogue Scale (VAS) scores on the day and the day after the final treatment. Results The differences in scar pigmentation, vascularity, and overall VSS scores were higher in the general anesthesia group than in the surface anesthesia group. Patients in the general anesthesia group had a lower pain level than those in the surface anesthesia group. After adjusting for confounding factors and propensity score matching, the outcome of VSS and VAS scores was stable. There was no statistical difference in the adverse effects and satisfaction between the two groups. Conclusion General anesthesia, as opposed to surface anesthesia, may not only ensure safety but also increase the effectiveness of MPR and lessen postoperative pain in the treatment of hypertrophic scars.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of general and surface anesthesia on micro-plasma radiofrequency of hypertrophic scar: A retrospective cohort study

Meng

Qian

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Compared to CO 2 laser, Er:YAG laser has a much higher absorption coefficient of water in skin, leading to less energy to ablate tissues and subsequently minimal thermal damages around the microchannels ( Waibel et al, 2017 ). Since CO 2 laser creates deeper MTZs, it is therefore preferable to Er:YAG laser for topical drug delivery, although both methods are effective at providing therapeutic agents through the SC ( Searle et al, 2021 ).…”

Section: Physical Transdermal Drug Delivery Systemsmentioning

confidence: 99%

Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Qin

Dai

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Psoriasis is a chronic, immune-mediated skin disorder involving hyperproliferation of the keratinocytes in the epidermis. As complex as its pathophysiology, the optimal treatment for psoriasis remains unsatisfactorily addressed. Though systemic administration of biological agents has made an impressive stride in moderate-to-severe psoriasis, a considerable portion of psoriatic conditions were left unresolved, mainly due to adverse effects from systemic drug administration or insufficient drug delivery across a highly packed stratum corneum via topical therapies. Along with the advances in nanotechnologies, the incorporation of nanomaterials as topical drug carriers opens an obvious prospect for the development of antipsoriatic topicals. Hence, this review aims to distinguish the benefits and weaknesses of individual nanostructures when applied as topical antipsoriatics in preclinical psoriatic models. In view of specific features of each nanostructure, we propose that a proper combination of distinctive nanomaterials according to the physicochemical properties of loaded drugs and clinical features of psoriatic patients is becoming a promising option that potentially drives the translation of nanomaterials from bench to bedside with improved transdermal drug delivery and consequently therapeutic effects.

show abstract

“…Laser treatment can selectively and precisely remove superficial skin in controlled and noncontact modes without the production of biohazardous waste [6]. Laser-assisted drug delivery has proven to be beneficial for treating melasma, actinic keratosis, skin cancers, vitiligo, and keloid scars in clinical practice [7,8].…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Delivery of Cosmeceutical Peptides Enhanced by Picosecond- and Nanosecond-Domain Nd:YAG Lasers with Quick Recovery of the Skin Barrier Function: Comparison with Microsecond-Domain Ablative Lasers

et al. 2022

View full text Add to dashboard Cite

Picosecond or nanosecond-domain non-ablative lasers generate faster photothermal effects and cause less injury than microsecond lasers. In this study, we investigated the enhancing effect of 1064 nm picosecond- and nanosecond-domain neodymium (Nd):yttrium–aluminum–garnet (YAG) lasers on the cutaneous delivery of cosmeceutical peptides. Microsecond-domain fractional ablative CO2 and fully ablative erbium (Er):YAG lasers were also used for comparison. In the Franz diffusion cell study, pig or mouse skin was treated with a laser before exposure to palmitoyl tripeptide (PT)-1, PT-38, and copper tripeptide (CT)-1 at a concentration of 150 μM. Psoriasiform, atopic dermatitis (AD)-like, and photoaged skins were also developed as permeation barriers. The non-ablative laser elicited the ultrastructural disruption of the stratum corneum and epidermal vacuolation. All laser modalities significantly increased the skin permeation of peptides in vitro. The non-ablative laser chiefly enhanced peptide delivery to the receptor compartment, whereas the ablative laser mainly increased the intracutaneous peptide deposition. The picosecond- and nanosecond-domain Nd:YAG lasers elevated the amount of PT-1 in the receptor up to 40- and 22-fold compared with untreated skin, respectively. Laser treatment promoted peptide delivery in barrier-deficient and inflamed skins, although this enhancement effect was less than that observed in healthy skin. Fluorescence microscopy indicated the capability of the non-ablative laser to deliver peptides to deeper skin strata. The ablative laser confined the peptide distribution in the epidermis. Confocal microscopy showed that peptides penetrated the skin along the microdots created by the fractional Nd:YAG and CO2 lasers. The skin barrier function determined by transepidermal water loss suggested quick recovery when using a nanosecond-domain laser (within 4 h). A longer period was needed for the skin treated with the fully ablative Er:YAG laser (76–84 h). Nanosecond non-ablative laser-facilitated peptide delivery may become an efficient and safe approach for cosmeceutical applications.

show abstract

Lessons Learned from the First Decade of Laser-Assisted Drug Delivery

Cited by 22 publications

References 59 publications

Effect of general and surface anesthesia on micro-plasma radiofrequency of hypertrophic scar: A retrospective cohort study

Effect of general and surface anesthesia on micro-plasma radiofrequency of hypertrophic scar: A retrospective cohort study

Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Cutaneous Delivery of Cosmeceutical Peptides Enhanced by Picosecond- and Nanosecond-Domain Nd:YAG Lasers with Quick Recovery of the Skin Barrier Function: Comparison with Microsecond-Domain Ablative Lasers

Contact Info

Product

Resources

About