Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Abstract

Psoriasis is a chronic, immune-mediated skin disorder involving hyperproliferation of the keratinocytes in the epidermis. As complex as its pathophysiology, the optimal treatment for psoriasis remains unsatisfactorily addressed. Though systemic administration of biological agents has made an impressive stride in moderate-to-severe psoriasis, a considerable portion of psoriatic conditions were left unresolved, mainly due to adverse effects from systemic drug administration or insufficient drug delivery across a highly packed stratum corneum via topical therapies. Along with the advances in nanotechnologies, the incorporation of nanomaterials as topical drug carriers opens an obvious prospect for the development of antipsoriatic topicals. Hence, this review aims to distinguish the benefits and weaknesses of individual nanostructures when applied as topical antipsoriatics in preclinical psoriatic models. In view of specific features of each nanostructure, we propose that a proper combination of distinctive nanomaterials according to the physicochemical properties of loaded drugs and clinical features of psoriatic patients is becoming a promising option that potentially drives the translation of nanomaterials from bench to bedside with improved transdermal drug delivery and consequently therapeutic effects.

ZIF-8 integrated with polydopamine coating as a novel nano-platform for skin-specific drug delivery

“…In particular, the zeta potential was lower than 5-FU@ZIF-8, which could increase its interaction with skin; (2) the nanoparticles with a size of less than 300 nm were reported to deliver their payloads to deeper skin layers, and the smaller the particle size of 5-FU@ZIF-8 favoured their skin penetration and drug delivery. 24,57 As a possible result of the penetration enhancement effect of ZIF-8 itself, the PDA coating did not further improve the drug retention in the skin.…”

“…The interaction of nanoparticles with skin is of high relevance to their dermal delivering behaviours, and with this regard, surface functionalization may be introduced to further enhance the dermal drug delivery of nanomedicines. 24 In our previous study, we developed a novel surface modification strategy for nanostructured lipid carrier (NLC) based oxidative polymerization of dopamine. The polydopamine (PDA) formed on the NLC surface, as a mussel adhesive protein-inspired molecule, was found to improve follicular drug delivery and cellular uptake of nanoparticles within the skin.…”

An Update on Photodynamic Therapy of Psoriasis—Current Strategies and Nanotechnology as a Future Perspective

“…Several studies have evaluated novel nanocarriers in PDT, including polymeric, lipidic, and metallic nanocarriers. Among the polymer-based nanoparticles, dendrimers, polymeric micelles, nanogels, nanospheres, and nanocapsules have been utilized in the PDT of various skin diseases [ 57 , 58 ]. Therefore, it is reasonable to investigate the role of these nanosystems in psoriasis treatment.…”

“…They are natural carriers, which makes them easily available and cost-effective. Among the lipid-based nanoparticles tested in combination with PDT for psoriasis treatment, we can distinguish poly-amphiphiles (such as niosomes), solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), as well as nanoemulsions [ 58 ].…”

Exploration of and insights into advanced topical nanocarrier systems for the treatment of psoriasis

“…These micelles have been designed for targeted drug delivery because of their easy structural deformation under the influence of pH, temperature, or reduction-oxidation reactions in vivo . Therefore, micelles are more suitable for local administration or in combination with other polymer materials when controlled drug release is required ( 54 ).…”