Leser‐Trélat Sign Associated with Sézary Syndrome

Abstract

A 74-year-old Japanese male had developed generalized erythroderma and rapid growth of multiple verrucous lesions over the entire surface of his face, trunk, and extremities three months before he was seen. Histologically seborrheic keratoses were revealed. Laboratory examinations showed peripheral leukocytosis with atypical lymphocytes and high levels of IgE and IgG. On the basis of these clinical and histopathologic findings, we diagnosed the patient as having Leser-Trélat sign associated with Sézary syndrome. The erythroderma subsided after administration of oral predonisone, and no new formations of seborrheic keratosis were observed. However, because of subsequent aggravation of the generalized erythroderma, we administered chemotherapy. Six months after the initial examination, lung cancer was found, and the patient subsequently died of respiratory and renal failure.

Eruptive Seborrheic Keratoses Are Associated With a Co-Occurring Malignancy in the Majority of Reported Cases: A Systematic Review

“…Of the 4 reports that noted recurrence of ESK in cancer patients, all were associated with a relapse of the primary cancer or a new malignancy. 25 - 28 These data suggest that there is a temporal relationship between ESK and malignancy that may not be strictly due to increased age.…”

Cutaneous T-cell lymphoma-associated Leser-Trélat sign: report and world literature review

“…We identified 28 individuals with Leser-Trélat signassociated lymphoma and leukemia (Table 1, ) and summarized the characteristics of 15 patients-! A B [3][4][5][6][7][8][9][10][11][12][13][14][15][16]).…”

Paraneoplastic pityriasis lichenoides in cutaneous lymphoma: case report and review of the literature on paraneoplastic reactions of the skin in lymphoma and leukaemia

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