Cutaneous T-cell lymphoma-associated Leser-Trélat sign: report and world literature review

Narala, Saisindhu; Cohen, Philip R.

doi:10.5070/d3231033672

Cited by 11 publications

(7 citation statements)

References 12 publications

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“…In 1900, Hollander was the first to describe SQ in association with malignancy, but the names Leser and Trélat remained associated with the disease. 1,2,5,26 .…”

Section: Discussionmentioning

confidence: 99%

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Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

Leles¹,

Capop²,

Crispim³

2021

JHS

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Leser-Trélat sign (TLS) is a rare paraneoplastic syndrome characterized by the sudden onset of multiple seborrheic keratoses (QS), indicating an underlying malignancy. The cancers most associated with TLS occur in the gastrointestinal tract and, as they are more common in elderly people, some authors question its legitimacy as a predictor of malignancy. So, this study aimed to compile all case reports published in the last ten years, to analyze their common characteristics, such as the sex and age of the people affected, as well as the main associated malignancies, the evolution of skin lesions and its relationship with the onset of cancer. A bibliographic search was carried out in the databases: Medical Literature Analysis and Retrieval System Online (Medline) via PubMed, Scientific Electronic Library Online (SciELO) and Latin American and Caribbean Literature in Health Sciences (LILACS), using the term: Leser-Trelat. Based on the selection criteria, 13 articles were included in this study and it was found that the disease is more common in the elderly, with no sex predilection. The most common location of QS was on the back and chest, with sudden onset and with a higher occurrence of gastric and hepatocellular adenocarcinoma, in addition to cutaneous T lymphoma. Despite the need for more studies to improve the understanding of the disease, it is concluded that TLS must indeed be considered a paraneoplastic syndrome and, therefore, an omen for screening for hidden malignancies.

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“…In 1900, Hollander was the first to describe SQ in association with malignancy, but the names Leser and Trélat remained associated with the disease. 1,2,5,26 .…”

Section: Discussionmentioning

confidence: 99%

“…Leser-Trélat sign (TLS) is a rare paraneoplastic syndrome characterized by the sudden eruption of multiple seborrheic keratoses (QS) in patients with underlying malignancy [1][2][3][4][5][6][7][8][9][10][11][12][13] hidden or known 14 . These benign skin lesions rapidly increase in number and size over a period of weeks to months.…”

Section: Introductionmentioning

confidence: 99%

Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

Leles¹,

Capop²,

Crispim³

2021

JHS

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“…The LTS is most frequently associated with adenocarcinomas (gastrointestinal in 32% of cases), followed by lymphoproliferative disorders in 20% and, more rarely, with carcinomas of the breast, lung, liver, kidney, prostate, ovary, and nasopharynx [5]. In addition, mycosis fungoides, Sézary syndrome, and plasmacytoma have been described in association with this paraneoplastic disorder [6].…”

Section: Sirmentioning

confidence: 99%

“…A careful search for an underlying malignancy should be undertaken. A physical examination with a complete blood count, serum biochemistry, chest X-ray, mammogram, Pap smear, PSA screening, upper GI endoscopy, and colonoscopy is required during this examination [5][6][7].…”

Section: Case Lettermentioning

confidence: 99%

Leser–Trélat syndrome: What does it hide?

Dassouli¹,

Douhi²,

Tahri³

et al. 2022

Our Dermatol Online

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Sir, Seborrheic keratoses (SKs) are common, benign, non-melanocytic epidermal tumors [1]. Still, they may be suspicious of other, more serious underlying conditions. Leser–Trélat syndrome may be considered a paraneoplastic condition characterized by the sudden onset of multiple SKs [2]. Herein, we report two cases of malignancy revealed by eruptive KS. The first case, an 83-year-old male with no notable pathological history, presented for two years with rapidly evolving lesions of the trunk over a six-month period. The patient also noticed for three months melena with transit disorders, justifying a consultation in which the diagnosis of sigmoid tumor was reached and the patient was referred for surgery. A clinical examination revealed multiple, sessile, exophytic tumors of round or oval appearance, 1 to 3 cm in diameter, well-delimited. The surface of the lesions was verrucous, brownish-black, with numerous, black, keratotic plugs (Fig. 1a). A dermoscopic examination revealed a cerebral appearance with pseudocysts and pseudocomedones (Fig. 1b). The diagnosis of seborrheic keratosis was thus reached.

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“…Возраст пациентов с СЛТ может быть различным, однако средний возраст появления данного синдрома составляет около 61 года. Сообщения о связи СЛТ с полом или какой-либо расой отсутствуют [22]. Особую онконастороженность должны вызывать пациенты молодого возраста, которым не свойственен сенильный кератоз.…”

Section: синдром лезера-треля (Sign Leser-trélat)unclassified

Paraneoplastic Leser-Trélat Syndrome: Clinical Manifestations, Diagnosis and Treatment

Gaydina

Дворников

Skripkina

2022

Arhivʺ vnutrennej mediciny

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Осмотр кожного покрова -широкодоступный и простой метод обследования пациента, который, тем не менее, позволяет диагностировать системные нарушения и заболевания на ранних стадиях. Врач любой специальности може т столкнуться в клинической практике с дерматологическими паранеопластическими синдромами, которые представляют собой группу кожных заболеваний, связанных со злокачественными новообразованиями, но не имеющих прямого отношения к первичной опухоли или ее метастазам. Своевременный анализ дерматологических паранеопластических синдромов позволяет заподозрить злокачественные опухоли, и срочно направить пациента к онкологу с целью ранней диагностики и лечения потенциально излечимого онкологического заболевания. В клинической практике достаточно часто встречается паранеопластический синдром Лезера-Треля (Leser-Trélat), который проявляется внезапным появлением множественных себорейных кератом (в основном, в области спины и живота) и увеличением их числа и размеров в течение небольшого промежутка времени (недели, месяцы). Лечение данного синдрома можно проводить как одновременно, так и после лечения основного злокачественного заболевания. Дерматологические паранеопластические синдромы требуют дальнейшего углубленного изучения для понимания патогенеза, создания четкой классификации и разработки алгоритмов действия врача. Ключевые слова: паранеопластические синдромы, дерматологические паранеопластические синдромы, синдром Лезера-Треля, кератома, множественные себорейные кератомы Конфликт интересовАвторы заявляют, что данная работа, её тема, предмет и содержание не затрагивают конкурирующих интересов Источники финансированияАвторы заявляют об отсутствии финансирования при проведении исследования Статья получена 31.01.2022 г. Принята к публикации 08.06.2022 г.

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Cutaneous T-cell lymphoma-associated Leser-Trélat sign: report and world literature review

Cited by 11 publications

References 12 publications

Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

Leser–Trélat syndrome: What does it hide?

Paraneoplastic Leser-Trélat Syndrome: Clinical Manifestations, Diagnosis and Treatment

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