Paraneoplastic pityriasis lichenoides in cutaneous lymphoma: case report and review of the literature on paraneoplastic reactions of the skin in lymphoma and leukaemia

Abstract

Paraneoplastic dermatoses are non-neoplastic skin disorders which occur in the context of an underlying malignant neoplasm. The classic paraneoplastic dermatoses are mostly associated with solid internal malignancies. They only rarely occur in the context of nodal or primary cutaneous lymphomas. Apart from these classic paraneoplastic dermatoses, there are additional skin disorders reported to occur in close association with haematological and lymphoproliferative disorders which can thus be regarded as paraneoplastic manifestations. We report for the first time two patients with pityriasis lichenoides et varioliformis acuta in association with mycosis fungoides. In addition, we review the literature on paraneoplastic dermatoses of the skin which have been described in patients with leukaemias and primary cutaneous lymphomas.

Lymphomatoid papulosis in children: a series of 25 cases

“…PL could be defined as a CTLPD, sometimes with a T‐cell clonal population . PL and mycosis fungoides in combination has already been described . For this reason, we would like to stress that while PL remains a benign disease in children, it should be seen as part of the spectrum of T‐cell lymphoproliferative disorders and, as such, requires long‐term follow‐up.…”

Lymphomatoid Papulosis Followed by Pityriasis Lichenoides: A Common Pathogenesis?

“…MF, Hodgkin lymphoma, and other lymphomas have been rarely reported in patients with PL. 8,38,[58][59][60][61][62][63][64][65][66][67][68] Whether some of these cases are really unrecognized LyP rather than PL is unclear.…”

Commentary about papular mycosis fungoides, lymphomatoid papulosis and lymphomatoid pityriasis lichenoides: more similarities than differences

“…Finally, although pityriasis lichenoides is generally regarded to be an inflammatory disease without malignant potential (an important distinction from LyP), we and others have observed patients who apparently developed pityriasis lichenoides, followed years later by typical MF or Hodgkin lymphoma . Moreover, we also have encountered patients with typical MF who had co‐existing self‐healing papules that had histopathologic features of PLC rather than LyP.…”