Leptin and ghrelin in chronic kidney disease: their associations with protein-energy wasting

Canpolat, Nur; Sever, Lale; Ağbaş, Ayşe; Taşdemir, Mehmet; Oruc, Cigdem; Ekmekçi, Özlem Balcı; Çalışkan, Salim

doi:10.1007/s00467-018-4002-7

Cited by 19 publications

(18 citation statements)

References 47 publications

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“…Other studies have not replicated the correlation between leptin and ghrelin and protein‐energy wasting. One study showed that leptin was associated with BMI but not renal function, and another study showed low levels of leptin in patients with protein‐energy wasting and no difference in ghrelin levels between children on dialysis with and without protein‐energy wasting . In addition, although children with higher GFRs have decreased appetite, the decreased appetite does not necessarily correlate with anthropometric measures …”

Section: Chronic Kidney Diseasementioning

confidence: 99%

Malnutrition in Children With Chronic Disease

Larson‐Nath

Goday

2019

Nut in Clin Prac

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Malnutrition occurs when nutrient intake does not meet the needs for normal body functions and as a consequence leads to alterations of growth and development in children. Chronic illness puts children at risk for developing malnutrition. Because of children's rapid periods of growth and development, early diagnosis, prevention, and management of malnutrition are paramount. The reasons for malnutrition in children with chronic disease are multifactorial and are related to the underlying disease and nonillness-associated factors. This review addresses the causes, evaluation, and management of malnutrition in pediatric congenital heart disease, chronic kidney disease, liver disease, and cystic fibrosis. (Nutr Clin Pract. 2019;34:349-358)

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Section: Chronic Kidney Diseasementioning

confidence: 99%

Malnutrition in Children With Chronic Disease

Larson‐Nath

Goday

2019

Nut in Clin Prac

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“…They are degraded by the kidney so it has been postulated that an imbalance of these hormones might contribute to the disturbed appetite and PEW in CKD. However, results of levels in CKD are variable and inconsistent and their role remains unclear [17][18][19].…”

Section: Nutritionmentioning

confidence: 99%

Protein energy wasting; what is it and what can we do to prevent it?

Rees

2019

Pediatr Nephrol

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Some children with declining height and BMI SDS fail to respond to optimisation of nutritional intake. As well as poor growth, they have muscle wasting and relative preservation of body fat. This is termed protein energy wasting (PEW). The process results from an interaction of chronic inflammation alongside poor nutritional intake. This review discusses the causes and potential preventative therapies for PEW.

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“…Metabolites 2020, 10, 98 2 of 11 lipid profile and serum adipokine levels [3][4][5]. Changes in adipokine levels have been discussed in the context of CKD progression and the risk of comorbidities [6][7][8][9]. Leptin is one of the hormones secreted by adipose tissue and has been recognized as a signaling molecule that regulates energy homeostasis [10,11].…”

Section: Introductionmentioning

confidence: 99%

Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease–The Possible Role of an Abnormal Serum Fatty Acid Profile

et al. 2020

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Chronic kidney disease (CKD) is associated with an increased level of leptin and an abnormal fatty acid (FA) profile in the serum. However, there are no data on the associations between them, and the reason for increased serum levels in patients with CKD is not well elucidated. Recently, we found that a CKD-related abnormal FA profile caused significant changes in the expression of genes involved in lipid metabolism in hepatocytes. The aim of this study was to examine whether leptin gene expression in subcutaneous adipose tissue (SAT) of patients with CKD may contribute to increased serum levels of this adipokine and whether the abnormal serum FA profile observed in CKD patients has an impact on leptin gene expression in adipocytes. The FA profile was measured in serum samples from patients with CKD and controls by GC-MS. The relative mRNA levels of leptin were measured in SAT by Real-Time PCR. Moreover, the effect of the CKD-related abnormal FA profile on leptin gene expression was studied in in vitro cultured 3T3-L1 adipocytes. Patients with CKD had higher concentrations of serum leptin than controls and higher expression level of the leptin gene in SAT. They also had increased serum monounsaturated FAs and decreased polyunsaturated FAs. The incubation of adipocytes with FAs isolated from CKD patients resulted in an increase of the levels of leptin mRNA. Increased leptin gene expression in SAT may contribute to elevated concentrations of these adipokine in patients with CKD. CKD-related alterations of the FA profile may contribute to elevated serum leptin concentrations in patients with CKD by increasing the gene expression of this adipokine in SAT.

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Leptin and ghrelin in chronic kidney disease: their associations with protein-energy wasting

Cited by 19 publications

References 47 publications

Malnutrition in Children With Chronic Disease

Malnutrition in Children With Chronic Disease

Protein energy wasting; what is it and what can we do to prevent it?

Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease–The Possible Role of an Abnormal Serum Fatty Acid Profile

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