2020
DOI: 10.3390/metabo10030098
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Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease–The Possible Role of an Abnormal Serum Fatty Acid Profile

Abstract: Chronic kidney disease (CKD) is associated with an increased level of leptin and an abnormal fatty acid (FA) profile in the serum. However, there are no data on the associations between them, and the reason for increased serum levels in patients with CKD is not well elucidated. Recently, we found that a CKD-related abnormal FA profile caused significant changes in the expression of genes involved in lipid metabolism in hepatocytes. The aim of this study was to examine whether leptin gene expression in subcutan… Show more

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Cited by 8 publications
(16 citation statements)
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“…A research scheme showing the recruitment of study subjects and collection of biological material from them is presented as a supplementary Figure S1. The characteristics of these patients had been reported previously [2,8]. Blood samples were taken after overnight fasting from all the study subjects.…”
Section: Study Groupmentioning
confidence: 99%
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“…A research scheme showing the recruitment of study subjects and collection of biological material from them is presented as a supplementary Figure S1. The characteristics of these patients had been reported previously [2,8]. Blood samples were taken after overnight fasting from all the study subjects.…”
Section: Study Groupmentioning
confidence: 99%
“…FA profiles were analyzed by gas chromatography-mass spectrometry (GC-MS) using QP-2010SE apparatus (Shimadzu, Kyoto, Japan), as described previously [2,8].…”
Section: Fatty Acid Determinationmentioning
confidence: 99%
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