LEP -2548G&gt;A Polymorphism of the Leptin Gene and Its Influence on the Lipid Profile in Obese Individuals

Ferreira-Julio, Maysa Araújo; Pinhel, Marcela Souza; Quinhoneiro, Driele Cristina Gomes; Nicoletti, Carolina Ferreira; Brandão, Antônio Carlos; Nonino, Carla Barbosa; Pinheiro, Sidney; Oliveira, Bruno Affonso Parenti de; Gregório, Michele Lima; Andrade, Days Oliveira de; Cortes-Oliveira, Cristiana; Souza, Dorotéia Silva Rossi

doi:10.1159/000371767

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…In this way, genetic variants associated with obesity have cumulative effects on obesity risk and related phenotypes [9]. Indeed, other studies have shown genetic variants related to lipid metabolism [10,11]. …”

Section: Introductionmentioning

confidence: 99%

The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass

et al. 2016

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Background/Aims: Genetic variants associated with obesity have cumulative effects on obesity risk and related phenotypes. This study aimed to estimate the contribution of a genetic predisposition score (GPS) calculated from 7 obesity-related polymorphisms to the improvement of biochemical parameters 1 year after Roux-en-Y gastric bypass (RYGB). Methods: Obese patients (n = 150; aged 47.2 ± 10.5 years) were enrolled and weight, body mass index (BMI), and biochemical parameters (glycemia and lipid profile) were evaluated preoperatively and 1 year after RYGB. A GPS was calculated with the polymorphisms rs1801282 of PPARG2, rs4994 of ADRB3, rs1800592 of UCP1, rs659366 and rs669339 of UCP2, rs7121 of GNAS1, and rs5443 of GNB3. We observed that 66.3% of the patients has a GPS >5. Results: During the preoperative period, the GPS showed a significant association with weight (β = -0.163; p = 0.020), BMI (β = -0.169; p = 0.038), and glucose concentrations (β = -0.177; p = 0.036). After sex and age adjustment, a higher GPS was associated with a greater reduction in glycemia (β = -0.158; p = 0.048), triglycerides (β = -0.256; p = 0.002), and total cholesterol (β = -0.172; p = 0.038) concentrations 1 year after surgery. Conclusion: Our data elucidated that a higher GPS provides a greater metabolic benefit of RYGB.

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Section: Introductionmentioning

confidence: 99%

The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass

et al. 2016

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Genetic Association of LEP Gene Polymorphisms with Obesity in Moroccan Individuals: Case–Control Study and Updated Meta-analysis

et al. 2023

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Association between leptin gene rs7799039 polymorphism and lipid profile changes induced by isotretinoin treatment in acne patients

Khabour¹,

Alzoubi²,

Firoz³

et al. 2018

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IntroductionIsotretinoin, a vitamin A-derived medication, is one of the effective treatments for severe acne. However, in a fraction of patients, this treatment causes significant adverse effects. Leptin is a pro-inflammatory cytokine that plays a role in apoptosis of adipose cells and sebaceous lipid metabolism. Thus, genetic polymorphisms in the leptin (LEP) gene may modulate the response to isotretinoin therapy. Here, we explore the contribution of rs7799039 polymorphism of the LEP gene in the adverse effects of the oral isotretinoin therapy among acne patients.Materials and methodsClinical parameters were obtained from 200 patients before and after isotretinoin treatment for acne. In addition, circulatory lipid profile and aspartate transaminase (AST) and alanine aminotransferase (ALT) enzymes from acne subjects before and 1 month after oral isotretinoin treatment were also measured.ResultsAn association between the rs7799039 polymorphism and the following lipid parameters: high-density lipoprotein (HDL) at baseline and after treatment, HDL % change, low-density lipoprotein % change and total cholesterol % change (P < 0.05). In addition, there was an association between the LEP polymorphism and higher AST and ALT at baseline and after treatment (P < 0.05).ConclusionIn conclusion, rs7799039 LEP polymorphism might modulate lipid parameters and liver enzymes, but not other major side effects of oral isotretinoin therapy.

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LEP -2548G>A Polymorphism of the Leptin Gene and Its Influence on the Lipid Profile in Obese Individuals

Cited by 3 publications

References 26 publications

The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass

The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass

Genetic Association of LEP Gene Polymorphisms with Obesity in Moroccan Individuals: Case–Control Study and Updated Meta-analysis

Association between leptin gene rs7799039 polymorphism and lipid profile changes induced by isotretinoin treatment in acne patients

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