1991
DOI: 10.4269/ajtmh.1991.44.536
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Leishmaniasis in Bahia, Brazil: Evidence that Leishmania amazonensis Produces a Wide Spectrum of Clinical Disease

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Cited by 313 publications
(218 citation statements)
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“…Furthermore, in contrast to experimental L. major infections in which host genetics control susceptibility, these studies demonstrate that the lack of IL-12 responsiveness may be dictated by the pathogen, rather than the host. Indeed, human L. amazonensis infection can be associated with several forms of chronic leishmaniasis (59). Our results suggest that the ability to promote a protective immune response in patients with chronic disease may sometimes be difficult, due to a parasite-mediated IL-12 nonresponsiveness.…”
Section: Discussionmentioning
confidence: 82%
“…Furthermore, in contrast to experimental L. major infections in which host genetics control susceptibility, these studies demonstrate that the lack of IL-12 responsiveness may be dictated by the pathogen, rather than the host. Indeed, human L. amazonensis infection can be associated with several forms of chronic leishmaniasis (59). Our results suggest that the ability to promote a protective immune response in patients with chronic disease may sometimes be difficult, due to a parasite-mediated IL-12 nonresponsiveness.…”
Section: Discussionmentioning
confidence: 82%
“…Foram detectadas amastigotas de Leishmania (Leishmania) amazonensis na medula óssea 4 . Outro estudo mostrou que de 46 casos de leishmaniose visceral, 11 tiveram como agente causal a Leishmania (Leishmania) amazonensis 5 . Outros trabalhos mostraram resultados semelhantes que detectaram Leishmania (Leishmania) braziliensis na medula óssea 13 e Leishmania (Leishmania) amazonensis em linfonodo 1 .…”
Section: Resultsunclassified
“…In fact, many of these parasites are capable of producing in the human host a variety of clinical manifestations rather than a localized skin disease. For instance, a proportion of clinical infections leading to nasal metastasis is most associated with L. (Viannia) braziliensis (Grimaldi et al 1987), but cases of this mutilating mucosal granulomata have also been reported as being associated with L. (V.) panamensis (Saraiva et al 1985), L. (V.) guyanensis (Santrich et al 1990), and L. (L.) amazonensis (Barral et al 1991). Consequently, parasite identification is important for the diagnosis of the disease, and for the evolution of therapy and prognosis.…”
Section: Epidemiological and Clinical Features Of Leishmania (Vianniamentioning
confidence: 99%