Leishmaniasis and Trypanosomiasis

Hutt, M. S. R.; Koberle, F; Salfelder, K.

doi:10.1007/978-3-662-00226-1_12

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…Acute mycocytolysis presenting with Pancarditis in human African trypanoso:niasis 835 contraction bands is often referred to as Magariiiofor a toxic or infective agent acting directly on the Torres lesion in human T. cruzi carditis (Andrade endocardium and myocardium has been emphasized and Andrade, 1971) and may lead to myocardial (Farrer-Brown et al, 1972). Farrer-Brown and granuloma formation (Andrade and Andrade, 1971;Tarbit (1972) showed the avascularity of the Hutt et al, 1973). Intimately associated with the affected atrioventricular valves in endomyocardial endocardial lesions were microscopical thrombi, fibrosis and they described for the first time the and these have also been recorded in human involvement of a pulmonary valve in this disease.…”

mentioning

confidence: 94%

Pancarditis affecting the conducting system and all valves in human African trypanosomiasis.

Poltera¹,

Cox²,

Owor³

1976

Heart

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mentioning

confidence: 94%

Pancarditis affecting the conducting system and all valves in human African trypanosomiasis.

Poltera¹,

Cox²,

Owor³

1976

Heart

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“…It causes primarily a zoonotic infection among foxes and dogs, and its vector is Phlebotomus longipalpis. It needs to be noted that the patterns and distribution of the varieties of human leishmaniasis are known to change (Hutt et al, 1973).…”

Section: Representative Trypanosomatidsmentioning

confidence: 99%

“…The face, arms, and legs are most commonly affected, and the lesions resemble lepromatous leprosy. Patients with this form of cutaneous leishmaniasis have a specific type of immune deficiency (Hutt et al, 1973). The vectors for L tropica are Phlebotomus sergenti, P. major, P. papatasii, P. caucasiens, and a few less known species of sandflies.…”

Section: Representative Trypanosomatidsmentioning

confidence: 99%

Introduction to the Parasitic Protozoa

Cheng

1986

General Parasitology

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“…As the lesion heals, the macrophages and organisms gradually diminish in number and the lymphocytes and plasma cells increase. Severe ulceration follows, and healing occurs in the presence of a nonspecific granulation tissue (Hutt et al, 1973).…”

Section: Introductionmentioning

confidence: 99%

Human cutaneous leishmaniasis: ultrastructural interactions between the inflammatory cells and leishman bodies in the skin lesions

El-Shoura¹,

Tallab

Bahamdan

1996

Parasite

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Summary :The ultrastructural interactions between the inflammatory infiltrate and Leishman bodies (LBs) were described in skin lesions from 16 patients with acute cutaneous leishmaniasis. In early stages of the inflammation, the cellular infiltrate consisted of both undifferentiated and differentiated (activated) monocytes (M), macrophages (Mc), multinucleated giant cells (MNGC), plasma cells (PC), lymphocytes (Ly), and fibroblasts (F). In late stages, the infiltrate was in the form of tuberculous granulomas consisted mainly of type I secretory, and type II vesicular epithelioid cells (ECs), in addition to remnant of some inflammatory cells seen in the early stages. The two types of ECs were found only in six patients. The activated M, Mc and MNGC were often parasitized by LBs. The parasites were enclosed within the host cell digestive vacuoles (DVs), or phagolysosomes, together with skin melanosomes which are known to have lysosomal effect. In the DVs, LBs either survived or were killed and expelled from the host cell cytoplasm. This study showed, for the first time, that the melanosomes were apparently involved in killing of the LBs possibly by increasing the fatal effects of the DVs hydrolytic enzymes. Plasma cells were packed with large « Russell's bodies » indicating a high cellular immunoglobulin activity. The large, granular lymphocytes were in close contact to the activated M, possibly to promote delivery of activation signals. The type I secretory ECs contained mucin-like granules with electrondense cores. In late stages of inflammation, the type II vesicular ECs contained lysosomal granules, and were found together with the type I ECs in broken-down tuberculous granulomas. The type I secretory ECs were previously thought to produce a mediator, or « granuloma factor » which recruits undifferentiated mononuclear cells to perpetuate the granulomatous process; while the type II vesicular ECs were thought to appear where the granulomatous process in brought to an end, preceeding the healing by fibrosis.KEYWORDS : cutaneous leishmaniasis, human, cellular infiltrate, inflammation, ultrastructure.MOTS CLES : leishmaniose cutanée, homme, infiltrat cellulaire, inflammation, ultrastructure. Résumé : LEISHMANIOSE CUTANÉE HUMAINE : INTERACTIONS ENTRE INFILTRAT INFLAMMATOIRE ET CORPS DE LEISHMAN DANS LES LÉSIONS CUTANÉES Les interactions entre infiltrat inflammatoire et corps de Leishman (LBs) sont décrites en microscopie électronique dans les lésions cutanées de 16 malades atteints de leishmaniose cutanée aiguë. Dans les premiers stades de l'inflammation, l'infiltrat cellulaire consiste à la fois en monocytes indifférenciés et différenciés (Mj, en macrophages (Mc), en cellules géantes multinuclées (MNGC), en plasmocytes (PC), en lymphocytes (Ly) et en fibroblastes (F). Dans les stades avancés, l'infiltrat est sous forme de granulomes tuberculeux consistant en cellules épithélioides de type I secrétoire et de type II vésiculaire (ECs), en plus de quelques cellules Inflammatoires observées au cours des premiers stad...

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Leishmaniasis and Trypanosomiasis

Cited by 3 publications

References 33 publications

Pancarditis affecting the conducting system and all valves in human African trypanosomiasis.

Pancarditis affecting the conducting system and all valves in human African trypanosomiasis.

Introduction to the Parasitic Protozoa

Human cutaneous leishmaniasis: ultrastructural interactions between the inflammatory cells and leishman bodies in the skin lesions

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