Leiomyosarcoma of the vulva

Shankar, Sonal; Todd, P.; Rytina, E.; Crawford, Robin

doi:10.1111/j.1468-3083.2006.01341.x

Cited by 15 publications

(27 citation statements)

References 5 publications

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“…1,2 Morphologically, leiomyosarcoma may arise from smooth muscles, blood vessels, rough ligaments, and erector-pili muscles. 1,3 The tumor usually arises in the area of Bartholin's gland, at the usual place of Bartholin duct cysts, and shows clinical similarities with them, leading to difficulties in diagnosis. 4 LMS occurs more frequently in women of middle and older ages (age range, 20-68); the average age at clinical presentation is approximately 30-40 years, and the youngest patient described was aged 14 years.…”

Section: Leiomyosarcoma Of the Vulvamentioning

confidence: 99%

“…Usually they are asymptomatic or present with non-specific local discomfort with vulvar mass, or chronic vulvar pruritus of longstanding, while pain, bleeding, or ulceration are late symptoms associated with poor prognosis. 3 The prognosis depends mainly on the size of the tumor, involvement of adjacent tissues, and mitotic activity. It is generally poor, as vulvar sarcomas are typically characterized by rapid growth, high metastatic potential, frequent recurrences, aggressive behavior, and high mortality rate.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Vulvar sarcomas are characterized by nonspecific clinical manifestations often leading to misdiagnosis, most commonly as Bartholin's cysts or abscesses. 3 The median age of occurrence is 50 years, but the interval is wide, depending on the morphological variant.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1

Chokoeva¹,

Tchernev

Cardoso

et al. 2015

Int J Immunopathol Pharmacol

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Malignant tumors of the female reproductive system are a serious health and social problem, as they are the second most common cause of death among women, after breast cancer. Their incidence has increased dramatically during recent years, probably due to the different sexual habits and changes in the prevalence of HIV/ AIDS and HPV virus carriers, among other factors. Vulvar tumors represent only 4% of all gynecological neoplasms, and they are fourth in frequency after tumors of the cervix, uterus, and ovary. Ninety eight percent of all vulvar tumors are benign and only 2% are malignant. The overall incidence of tumors with vulvar location is between two and seven cases per 100,000 women, and it increases with age, while the death rate is estimated at 0.7 per 100,000 women. Sarcomas of the vulva comprise approximately 1-3% of all vulvar cancers, with leiomyosarcomas, epithelioid sarcomas, and rhabdomyosarcomas being the most common among them. They are characterized by rapid growth, high metastatic potential, frequent recurrences, aggressive behavior, and high mortality rate. In this paper, we present the most common forms of sarcomas of the vulva (leiomyosarcoma, epithelioid sarcoma, malignant rhabdoid tumor, rhabdomyosarcoma) in order to emphasize the broad differential diagnosis, rare appearance, non-specific clinical picture, aggressive course, and high mortality.

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Section: Leiomyosarcoma Of the Vulvamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1

Chokoeva¹,

Tchernev

Cardoso

et al. 2015

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

show abstract

“…По данным исследования S. Shankar и соавт., опухоль чаще всего локализуется в области бартолиновой железы, в типичном для кист бартолиновых протоков месте, поэтому ее клинические проявления сходны с проявлениями воспалительных процессов бартолиновой железы, что приводит к трудностям в диагностике [5]. Опухоли характеризуются неспецифическими клиническими проявлениями, часто приводящими к ошибочному диагнозу, нередко первоначальный диагноз указывается как бартолиновая киста или абсцесс [7].…”

Section: саркомы вульвыunclassified

“…В большинстве публикаций демонстрируется крайне неблагоприятное течение заболевания [3][4][5]. По данным исследования S. Dewdney и соавт., опухоль характеризуется быстрым ростом, высоким метастатическим потенциалом, частыми рецидивами, агрессивным поведением и высоким уровнем смертности [4].…”

Section: обзорные статьиunclassified