The purpose of the study was to summarize the available data on etiology, diagnosis, clinical symptoms and signs as well as on various approaches to the treatment of neuroendocrine cervical tumors.Material and Methods. The relevant sources were searched in the PubMed and cochrane Library systems, and publications from 1980 to 2019 were analyzed, 53 of which were used to write this review. We also included 6 case reports from N.N. Petrov National Research Center of Oncology.Results. Neuroendocrine tumors (NETs) are extremely rare and aggressive malignancies of the female genital tract, among which NETs of the cervix are the most common. Due to the rarity of these tumors, there are currently no treatment standards based on prospective, well-planned clinical trials. For these reasons, NETs present a significant therapeutic challenge for clinicians. Case reports. Six patients ranged in age from 32 to 71 years, with a median age of 46 years, were diagnosed with large-cell neuroendocrine carcinoma (4 patients) and small-cell neuroendocrine carcinoma (2 patients). One patient with stage IIIA dropped out of the follow-up schedule. Out of 5 followed up patients, 2 patients with stage IIIA and IIB died of disease progression after 6 and 11 months, respectively. One patient with stage IB1 is in remission for 16 months. Two patients with stage IIB continue to receive primary treatment.Conclusion. Neuroendocrine carcinoma of the cervix is a rare variant of cervical cancer. The choice of treatment options is decided only by a multidisciplinary team of doctors, and further research is required.
Objective: to identify the features of the frequency of occurrence, clinical presentation, methods of diagnosis and treatment of vitreous cell carcinomas of the cervix.Materials and methods. The publication highlights 4 cases of diagnosed GCC of the cervix at the N. N. Petrov National Medical Research Oncology Center for a five-year period from 2015 to 2020.Results. The incidence of vitreous cell carcinomas of the cervix is 1.08 % of all cases of cervical cancer. The study included only patients with locally advanced forms of stage II and III diseases. All patients underwent individualized treatment. In three cases, progression of the disease was observed during treatment.Conclusions. The main problem is the rare occurrence of vitreous cell carcinomas of the cervix. The choice of treatment tactics is decided only on a multidisciplinary basis and requires further research.
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