Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas

Leibsohn, Steven; d'Ablaing, Gerrit; Mishell, Daniel R.; Schlaerth, John B.

doi:10.1016/0002-9378(90)91298-q

Cited by 378 publications

(134 citation statements)

References 12 publications

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“…By reviewing literature for incidental ULMS rate in patients with myoma resections the percentages varied from 0.07 [10] to 0.49 [11]. Our percentage of 0.51 is at the upper bound of values reported previously.…”

Section: Discussionmentioning

confidence: 51%

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Effects of morcellation on long-term outcomes in patients with uterine leiomyosarcoma

Nemec

Inwald

Buchholz

et al. 2016

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 51%

“…In der Literaturübersicht variierte der Anteil der zufällig entdecken ULMS bei Patientinnen mit Myom Resektionen von 0,07% 9 bis 0,49% 11 Myometriumsinvasion und über die Unfähigkeit, die Grenzen der Läsion und der Nekrose zu bewerten wird in der Literatur berichtet. 22 …”

Section: Diskussionunclassified

Effects of morcellation on long-term outcomes in patients with uterine leiomyosarcoma

Nemec

Inwald

Buchholz

et al. 2016

Arch Gynecol Obstet

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“…Usually, the LMS is diagnosed by pathological examination of hysterectomy or myomectomy specimen [20]. The rate of LMS in hysterectomies performed for presumed uterine leiomyomas is approximately 0.1%-0.3% [21]. Overall, uterine LMS is easily diagnosed, thanks to histopathological features such as severe nuclear atypia, high mitotic rate usually exceeding 10 mitotic figures per 10 HPFs, necrosis and atypical mitotic figures.…”

Section: Resultsmentioning

confidence: 99%

Can aquaporins be used as diagnostic and prognostic markers for uterine smooth muscle tumours?

Alabalık

Türkçü

Keleş

et al. 2016

Biotechnology & Biotechnological Equipment

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Generally, uterine leiomyosarcoma is easily diagnosed. However, uterine smooth muscle tumours which show atypical histological features and unusual growth patterns may mimic malignancy and may not be easily diagnosed. In this study, our aim is to show the expressions of Aquaporin3, Aquaporin7 and Aquaporin9 in uterine smooth muscle tumours, and to investigate if aquaglyceroporins can be used as diagnostic and prognostic markers to start rapidly an appropriate treatment for patients with these tumours in order to extend the survival time. We determined that there had been 74 patients diagnosed with uterine smooth muscle tumours. We divided patients into four groups based on the diagnosis: bizarre leiomyoma, smooth muscle tumour of uncertain malignant potential, leiomyosarcoma and leiomyoma. Aquaporin3, Aquaporin7 and Aquaporin9 were detected by using monoclonal anti-Aquaporin3, antiAquaporin7 and anti-Aquaporin9 antibodies, respectively. In leiomyosarcoma group, we observed a statistically significant relation of Aquaporin3 expression with survival time, grade, stage, mitotic index and Ki-67 score. A significant relation of both Aquaporin7 and Aquaporin9 expressions with survival time, grade, stage was not statistically detected in leiomyosarcoma group. The decrease of Aquaporin3 expression can be used as important diagnostic and prognostic marker. Aquaporin7 and Aquaporin9 expressions cannot be used as diagnostic and prognostic markers.

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“…Previously reported rates of occult sarcoma have ranged from 0 to 1:204 (11,16) in analyses limited to women with presumed myomas, which may confer a higher likelihood of sarcoma. When developing their recommendations, the FDA used available reports of occult sarcoma in a pooled analysis to derive an estimate of 1:352 risk of occult sarcoma in women undergoing hysterectomy or myomectomy for presumed myomas.…”

Section: Discussionmentioning

confidence: 98%

“…The incidence of occult sarcoma in women undergoing hysterectomy is unclear with rates ranging from 1 in 204 to 1 in 667 in women with presumed myomas (10,11). Risk estimates from the FDA and American College of Obstetricians and Gynecologists range from 1 in 352 to 1 in 500, respectively, for women undergoing surgery for presumed myomas (12,13).…”

Section: Introductionmentioning

confidence: 99%

Risk of Occult Uterine Sarcoma in Women Undergoing Hysterectomy for Benign Indications

Kang

et al. 2015

Journal of Minimally Invasive Gynecology

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Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas

Cited by 378 publications

References 12 publications

Effects of morcellation on long-term outcomes in patients with uterine leiomyosarcoma

Effects of morcellation on long-term outcomes in patients with uterine leiomyosarcoma

Can aquaporins be used as diagnostic and prognostic markers for uterine smooth muscle tumours?

Risk of Occult Uterine Sarcoma in Women Undergoing Hysterectomy for Benign Indications

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