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OBJECTIVE: To investigate the association between maternal serum neutrophil-to-lymphocyte ratios (NLRs) and pregnancy outcomes in women with familial mediterranean fever (FMF). BACKGROUND: FMF exists worldwide, it primarily affects Mediterranean countries METHODS: We retrospectively analysed data from 269 pregnant women, who underwent a routine prenatal follow-up and delivery in our hospital from 2016 to 2020. Clinical and demographic data, including age, gravida, parity, abortus, proteinuria in the fi rst trimester, NLR, obstetrical complications, gestational age at delivery, birthweight were retrieved from the patients' medical records. Data from 67 pregnant women with FMF and 202 healthy pregnant women were compared. RESULTS: Patients with FMF showed higher rates of preeclampsia and primary caesarean delivery; however, there were no differences between the groups in terms of other obstetric complications or adverse neonatal outcomes. In both the FMF and control groups, NLRs in the third trimester were signifi cantly higher than those in the fi rst trimester. Additionally, patients in the FMF group demonstrated higher NLRs than patients in the control group in the third trimester. CONCLUSIONS: The NLRs are a haematological parameter that can be used to predict subclinical infl ammation and the effects of ongoing subclinical infl ammation on the pregnancy outcomes in women with FMF (Tab. 4, Ref. 39).

We aimed to determine the presence of SKI-interacting protein (SKIP) expression in malignant pleural mesothelioma (MPM) and its effect on prognosis by investigating SKIP correlation with the Ki-67 proliferation index and prognostic parameters. Pathological preparations of the patients diagnosed with MPM between 2006 and 2012 were evaluated. Immunohistochemical analyses were performed to evaluate the expression of SKIP and the Ki-67 proliferation index. Correlations between SKIP expression, clinicopathological factors and survival were investigated. Survival data were calculated using the Kaplan-Meier method, and Cox regression analysis was used to evaluate the prognostic value of the variables. In total, 52 patients were evaluated in the study; 36 of them were male and 16 were female. The mean age of the patients was 62.3 ±12.2 years. The median overall survival period was 8.5 months. Factors negatively affecting general survival in the univariate analysis included high SKIP expression, Ki-67 proliferative index over 30%, presence of non-epithelioid type MPM and stage III-IV disease (p < 0.05). Cox regression analysis revealed that high SKIP expression, high Ki-67 proliferative index and presence of non-epithelioid type MPM are independent factors that affect the survival rate. Higher SKIP expression is associated with poor prognosis in MPM.

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Objective: The aim of the study was to provide an overview to infectious and reactive cytological effects of intrauterine devices, which are one of the most widely used methods of contraception, with the results we obtained in the Mardin region. Material and Method:We evaluated together the pap smears of the 300 intrauterine device (+) and 300 intrauterine device (-) patients sent to the pathology department in the period of 2010-2011. Genital infection rates and frequency of reactive-dysplastic cellular changes were statistically compared between the groups together with the literature data. Results:In the intrauterine device (+) group, 2 (+) and more severe inflammation was observed in 66.3% of cases. Bacterial vaginosis (26%), candida (12%) and trichomonas vaginalis (8%) were recorded as the most common infectious agents, followed by actinomyces (4%). Between the groups of intrauterine device (+) and (-), no significant difference was observed in terms of the incidence of squamous cell abnormalities, except ASC-US (p=0.02). In the intrauterine device (+) group, the presence of atypical glandular cells and reactive findings was significantly higher than the control group. After the removal of the intrauterine device, 61 cases that had control smears showed regression, with a rate of %75.4 (n=46). Conclusion:The local irritative and inflammatory effect of intrauterine devices basically causes reactive and regenerative changes mostly in glandular cells. Intrauterine devices disrupt the genital flora and significantly increase the frequency of genital infection by creating a foreign body reaction. Bulgular: Rahim içi araç (+) hasta grubunda 2 (+) ve üzerinde inflamasyon yoğunluğu gösteren olguların oranı %66 olarak izlenmiştir. En sık enfeksiyon etkeni olarak, bakteriyel vajinozis (%26), candida (%12) ve trikomonas vajinalis (%8) kaydedilmiştir. Aktinomiçes ise %4 oranında izlenmiştir. Rahim içi araç (+) hastalarda, (-) olanlara göre ASC-US ve AGC görülme sıklıkları anlamlı olarak yüksek izlenmiştir (p=0,02, p<0,01). Ayrıca skuamöz metaplazi, tubal metaplazi, sitoplazmik balon vakuollü hücreler, HGSIL'i taklit eden izole hücreler gibi reaktif bulguların izlenme sıklığı rahim içi araç (-) gruba göre anlamlı oranda yüksek izlenmiştir. Rahim içi araç çıkartıldıktan sonra takip smirleri olan 61 olguda %75,4 (n=46) oranında bulgularda gerileme saptanmıştır.Sonuç: Rahim içi araç lokal irritatif ve inflamatuvar etkisi ile temel olarak glandüler hücrelerde belirgin reaktif ve rejeneratif değişikliklere neden olmaktadır. Yabancı cisim ortamı yaratarak genital florayı bozmakta ve genital enfeksiyon sıklığını belirgin ölçüde artırmaktadır. Kendi bölgemizden elde edilen sonuçlar da bu bulguları destekler yöndedir.

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We explored the effects of subcutaneously injected Ecballium elaterium (L) A. Rich. (EE) extract on skin wound-healing in rats, as well as the effects on the liver and pancreas. Twenty-eight rats were divided into two groups of 14 each: a saline control group (S) and an EE group. Both groups were divided into two subgroups according to the day of sacrifice (S-7 and S-14, and EE-7 and EE-14). All animals received 2.5 cm skin incisions followed by subcutaneous injections of either saline or 2.5 mg/kg EE per margin (5 mg/kg in total). The S and EE groups were compared in terms of the severity and type of local and neighbouring inflammation, vascularization, fibrosis and effects on the liver and pancreas. In addition, apoptosis and vascularity between S and EE groups were compared immunohistochemically with caspase-3 and cd-34 antibodies. There was no significant difference between the staining rates of caspase-3 and cd-34 in the immunohistochemical assay between the S and E groups. Subcutaneous EE was not toxic to the pancreas or liver; the EE-14 group exhibited less fibrosis than the S-14 group. Therefore, it can contribute to the proper closure of the lesion by reducing fibrosis during wound healing.

Objectives: Intraoperative pathology consultation (IOPC) is one of the most important and most difficult processes of pathology practice and the review of the results is accepted as a quality-control method in pathology laboratories. Because of the obligation of being made under stress and quickly, IOPC process is an error-prone method every time.Methods: In this study, the IOPC cases that were examined in Dicle University Medical Faculty between the years of 2007-2012 are reviewed.Results: 1758 (97.08%) of 1811 IOPC cases were diagnosed correctly. Of 53 cases that were diagnosed wrongly, 39 (2.15%) and 14 (0.77%) were diagnosed as wrong negative and wrong positive respectively. In our series it is detected that, of 53 wrongly diagnosed cases, the wrong diagnose was related to comment error in 35, to macroscopic sampling error in 15, and to technical error in 3. In the tissues of IOPC cases, the ovary materials constituted the first frequency. The 8 of 449 evaluated ovary cases were diagnosed wrongly and when 27 cases in which the diagnose was left to paraffin sections were excluded, the accuracy rate was determined as 98.11%. Conclusion:In our series, this rate relating to IOPC of ovary tissues seems as the highest accuracy rate in the literature.