Lupus miliaris disseminatus faciei (LMDF) is a chronic and uncommon inflammatory dermatosis, characterized by yellowish-red papules, especially on the face and around the eyelids. It is considered to be a reaction to destroyed hair follicles. We dermoscopically evaluated two patients diagnosed with LMDF. Dermoscopy revealed follicular keratotic plugs and vascular structures. We discuss these cases and other diseases dermoscopically showing keratotic plugs.

Prepubertal unilateral gynecomastia is an extremely rare condition. At present, its etiology and management strategy are not well known. Two unrelated prepubertal boys of ages 8 and 9 who presented with complaints of unilateral enlargement of breast tissue are reported. Physical examination, biochemical, hormonal and oncologic work-up findings were normal. Both patients were treated with peripheral liposuction successfully. Histopathological and immunohistochemical examinations showed benign fibroglandular gynecomastia and intensive (3+) estrogen receptor expression in 100% of periductal epithelial cells. Although an extremely rare and generally benign condition, patients with prepubertal unilateral gynecomastia should have a full endocrine and oncologic work-up.

The common variable immunodeficiency disease (CVID) is the most common symptomatic primary antibody deficiency. It is the most frequently observed cause of panhypogammaglobulinemia in adults. Here, we present a case of systemic amyloidosis that developed secondary to the common variable immunodeficiency disease causing recurrent infections in a young female patient. A 24-year-old female patient, who was under treatment at the gynecology and obstetrics clinic for pelvic inflammatory disease, was referred to our clinic when she was observed to have swellings in her legs, hands, and face. She had proteinuria at a rate of 3.5 gr/day, and her serum albumin was 1.5 gr/dl. The levels of immunoglobulins are IgG: 138 mg/dl, IgA: 22,6 mg/dl, and IgM: 16,8 mg/dl. The renal USG revealed that the kidneys were observed to be enlarged. Since the patient had recurrent infections, hypogammaglobulinemia, nephrotic range proteinuria, and enlarged kidneys in the renal USG, she was thought to have type AA amyloidosis and therefore underwent a renal biopsy. The kidney biopsy revealed amyloid (+). So the patient was diagnosed with AA type of amyloidosis secondary to common variable immunodeficiency disease. A treatment regimen (an ACE inhibitor and a statin) with monthly administration of intravenous immunoglobulin was started.

Objective: The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model. Materials and Methods: Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined. Results: There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin (median = 1) and the control group (median = 2; p < 0.05). The grade of inflammation of the curcumin (median = 1) and the sham (median = 0) group was significantly lower than that of the control group (median = 3; p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham (48.3 ± 11.8 µg/mg) and the curcumin (63.8 ± 13.9 µg/mg) group compared to the control group (85.7 ± 22.1 µg/mg; p < 0.05). Conclusion: These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation.

Objectives: Intraoperative pathology consultation (IOPC) is one of the most important and most difficult processes of pathology practice and the review of the results is accepted as a quality-control method in pathology laboratories. Because of the obligation of being made under stress and quickly, IOPC process is an error-prone method every time.Methods: In this study, the IOPC cases that were examined in Dicle University Medical Faculty between the years of 2007-2012 are reviewed.Results: 1758 (97.08%) of 1811 IOPC cases were diagnosed correctly. Of 53 cases that were diagnosed wrongly, 39 (2.15%) and 14 (0.77%) were diagnosed as wrong negative and wrong positive respectively. In our series it is detected that, of 53 wrongly diagnosed cases, the wrong diagnose was related to comment error in 35, to macroscopic sampling error in 15, and to technical error in 3. In the tissues of IOPC cases, the ovary materials constituted the first frequency. The 8 of 449 evaluated ovary cases were diagnosed wrongly and when 27 cases in which the diagnose was left to paraffin sections were excluded, the accuracy rate was determined as 98.11%. Conclusion:In our series, this rate relating to IOPC of ovary tissues seems as the highest accuracy rate in the literature.

Placental site trophoblastic tumor (PSTT) is a highly rare form of gestational trophoblastic diseases that arise from intermediate trophoblastic cells. By presenting this case, we aimed to review the treatment and diagnosis, approach to PSTT.A 31-year-old (G2P1A1L1) patient had abnormal vaginal bleeding. Serum ß-HCG was 5.82 mIU/ml and the transvaginal USG detected a polypoid mass in uterine cavity. Probe curettage was performed. Histopathologic specimens were confirmed as PSTT. No metastasis was detected. A total abdominal hysterectomy was performed.PSTT is a rare tumor. In contrast to other trophoblastic tumors, PSTT produces a small amount of ß-HCG and it is relatively insensitive to chemotherapy. Adjuvant chemotherapy is suggested to follow surgical treatment in the cases with metastasis.

Primary thyroid lymphomas are lymphomas which are localized only to thyroid gland or thyroid gland and surrounding lymph nodes. Frequently these are mucosa associated lymphoid tissue (MALT) lymphomas with B cell origin. Our case is a 78-year-old female patient who admitted with a neck mass and had been operated with the suspicion of malignancy. Histopathological examination revealed diffuse proliferation of atypical lymphoid cells that consists of small to medium sized cells, with irregular nuclear contours, some of which resemble centrocytes. Immunohistochemical staining was positive for CD20, CD79alpha, CD43, and lambda while negative for CD3, CD30, CD15, bcl-2, bcl-6, CD68, CD138, CD5, and CD10. With these finding, the case was considered as "primary thyroid MALT lymphoma". Thyroid MALT lymphomas are characterized with the presence of atypical lymphocytes that originate from the marginal zones of lymhoid follicles. Immunohistochemically, while these lymphomas express the B cell associated antibodies (CD20, CD22, CD79a), conversely CD5, CD10, and CD3 expressions are not seen. Keywords: CD20; MALT lymphoma; thyroid Özet Primer tiroid lenfoması, sadece tiroidi ya da tiroid ve bölgesel lenf bezlerini tutan lenfomadır. Sıklıkla B hücre kökenli mukoza ilişkili lenfoid doku (MALT) lenfomalardır. Vakamız boyunda kitle nedeniyle başvuran, malignite kuşkusuyla opere olmuş 78 yaşında kadın hastadır. Histopatolojik incelemede, küçük-orta boyda, düzensiz nükleer sınırlı, bir kısmı sentrositlere benzeyen hücrelerden oluşan diffüz atipik lenfoid hücre infiltrasyonu izlendi. İmmünohistokimyasal olarak CD20, CD79alfa, CD43 ve lambda pozitif, CD3, CD30, CD15, bcl-2, bcl-6, CD68, CD138, CD5 ve CD10 negatif boyandı ve vaka "primer tiroid MALT lenfoması" olarak değerlendirildi. Tiroid MALT lenfomaları lenfoid foliküllerin marjinal zonlarından köken alana atipik lenfositlerin varlığı ile karakterizedir. İmmünohistokimyasal olarak B hücre ilişkili antikorları (CD20, CD22, CD79a) eksprese ederken CD5, CD10 ve CD3 ekspresyonu görülmez. Anahtar kelimeler: CD20; MALT lenfoma; tiroid Giriş Primer tiroid lenfoması, sadece tiroidi ya da tiroid ve bölgesel lenf bezlerini tutan lenfomadır. Seyrek görülür. Tüm tiroid malignitelerinin %5'ini; nonHodgkin ekstranodal lenfomaların %3'ünü oluşturur. Sıklıkla B hücre kökenli mukoza ilişkili lenfoid doku (MALT) lenfomalardır (1-4).

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