Left ventricular volumes determined by two-dimensional echocardiography in a normal adult population

Wahr, Dennis; Wang, Yin Shi; Schiller, Nelson B.

doi:10.1016/s0735-1097(83)80200-9

Cited by 176 publications

(61 citation statements)

References 13 publications

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“…1,19,[22][23][24] The reference values for volumetric measurements are based on more limited data for 52 volunteers. 1,25 The literature provides several studies on reference limits with smaller sample sizes. 26 -32 However, studies on reference limits with a sample size Ͼ200 are very limited.…”

Section: Discussionmentioning

confidence: 99%

Distribution and Categorization of Left Ventricular Measurements in the General Population

Wild

Sinning

Roth

et al. 2010

Circ: Cardiovascular Imaging

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Background-Echocardiography, the dominant imaging modality for quantification of left ventricular metrics, has undergone continuing development in the past few decades. However, given the lack of population-based data, current guidelines are still based on restricted and small data sets analyzed with methods including expert opinion. This work presents empirically derived reference values from a large-scale, epidemiologic study conducted with state-of-the-art imaging technology and methods. Methods and Results-The distribution of echocardiographic measurements of the left ventricle was analyzed in a population-based sample of 5000 mid-Europeans from the Gutenberg Heart Study in Germany. The randomly selected, noninstitutionalized sample provides data on apparently healthy individuals, as well as on those with prevalent disease. Standardized echocardiograms were recorded in a comprehensive data set at a single site with centralized training and certification of sonographers. Sex-specific reference limits and categories indicating the grade of deviation from the reference were calculated, and nomograms were created by quantile regression. Detailed information is given on the association between left ventricular geometry and age. Conclusions-The rapidly evolving echocardiographic technology with persistent improvements in image quality and new measurement conventions require the evaluation of new reference limits for left ventricular metrics. The present investigation formulates reference limits and nomograms from state-of-the-art technology and methods based on a large population-based data set. The distribution of echocardiographic measures of left ventricular geometry presents, in part, nonlinear associations with age, which should be the subject of future investigations. (Circ Cardiovasc Imaging. 2010;3:604-613.)

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Section: Discussionmentioning

confidence: 99%

Distribution and Categorization of Left Ventricular Measurements in the General Population

Wild

Sinning

Roth

et al. 2010

Circ: Cardiovascular Imaging

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“…Routine echocardiograms are performed periodically to assess LVEF measured using a biplane method. 22 Left ventricular geometry is assessed measuring the sphericity index (SI), calculated as the ratio between the left ventricular transverse and longitudinal diameter in diastole.…”

Section: Methodsmentioning

confidence: 99%

Carvedilol in children with cardiomyopathy: 3-year experience at a single institution

Rusconi

Gómez-Marı́n

Rossique-Gonzalez

et al. 2004

The Journal of Heart and Lung Transplantation

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Background: Carvedilol reduces mortality and hospitalization in adults with congestive heart failure. Limited information is available about its use in children. Methods:We reviewed the medical records of 24 children with dilated cardiomyopathy and left ventricular ejection fraction of Յ40%, who were treated with carvedilol as adjunct therapy to angiotensinconverting enzyme inhibitors, digoxin and diuretics. Results:Carvedilol was initiated 14.3 Ϯ 23.3 (mean Ϯ SD) months after the diagnosis of cardiomyopathy. Mean age at initiation of therapy was 7.2 Ϯ 6.4 years. The mean initial and maximum doses were 0.15 Ϯ 0.09 and 0.98 Ϯ 0.26 mg/kg/day. Adverse effects occurred in 5 patients (21%). Two patients (8%) required discontinuation of the drug within 5 weeks of the initial dose. The remaining 22 patients tolerated carvedilol for a mean follow-up period of 26.6 Ϯ 14.7 months. Among these 22 patients, mean left ventricular ejection fraction improved from 24.6 Ϯ 7.6% to 42.2 Ϯ 14.2% (p Ͻ 0.001), and mean sphericity index from 0.86 Ϯ 0.11 to 0.74 Ϯ 0.10 (p Ͻ 0.001). New York Heart Association functional class improved in 15 patients (68%). One patient (4%) died and 3 (14%) were transplanted. Conclusions: Carvedilol, in addition to standard therapy for dilated cardiomyopathy in children improves cardiac function and symptoms; it is well tolerated, with minimal adverse effects, but close monitoring is necessary as it might worsen congestive heart failure and precipitate asthma. Control studies are necessary to assess the effect of carvedilol on mortality and hospitalization rates.

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“…Both investigators evaluated the exams and disagreements were solved by consensus. The area-length method was used to determine ejection fraction 12 .…”

Section: Doppler Echocardiographymentioning

confidence: 99%

Nível de NT-proBNP em pacientes com síndrome coronariana aguda sem supradesnivelamento do segmento ST

Castro¹,

Alencar²,

Barbosa³

et al. 2011

Arq. Bras. Cardiol.

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Left ventricular volumes determined by two-dimensional echocardiography in a normal adult population

Cited by 176 publications

References 13 publications

Distribution and Categorization of Left Ventricular Measurements in the General Population

Distribution and Categorization of Left Ventricular Measurements in the General Population

Carvedilol in children with cardiomyopathy: 3-year experience at a single institution

Nível de NT-proBNP em pacientes com síndrome coronariana aguda sem supradesnivelamento do segmento ST

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