Nível de NT-proBNP em pacientes com síndrome coronariana aguda sem supradesnivelamento do segmento ST

Castro, Luiz Ricardo A.; Alencar, Maria Clara; Barbosa, Márcia M.; Nunes, Maria do Carmo Pereira; Cardoso, José Ronaldo; Ribeiro, Antônio Luiz Pinho

doi:10.1590/s0066-782x2011005000114

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…Many clinical trials have mainly assessed the diagnostic and prognostic implications in various clinical settings, focusing especially on HF and left ventricular remodeling after MI [ 25 , 26 ]. Furthermore, recent data also suggested that NT-proBNP is associated with myocardial necrosis, irrespective of left ventricular ejection fraction [ 27 , 28 ] and 6-month MACEs of AMI [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Biomarker for the Prediction of Major Adverse Cardiac Events in Patients with Non-ST-Segment Elevation Myocardial Infarction

Shon

Bae

Kim

et al. 2017

Osong Public Health Res Perspect

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N-terminal pro-brain natriuretic peptide (NT-proBNP) is a well-known biomarker for the diagnosis and prognosis of heart failure, and is directly associated with myocardial dysfunction. We evaluated the prognostic value of NT-proBNP for major adverse cardiac events (MACEs) among patients with non-ST-segment elevation myocardial infarction (NSTEMI) from the Korea Acute Myocardial Infarction Registry during their mid-term follow-up period. In this paper, we analyzed NT-proBNP according to various MACE and level of NT-proBNP. We used multivariate logistic regression to determine the risk factors according to MACE type and NT-proBNP levels, and to identify the cutoff value for each MACE by using the receiver operating characteristic (ROC) curve. NT-proBNP was a significant variable among cardiac deaths (p = 0.016), myocardial infarction (p = 0.000), and coronary artery bypass grafting (CABG) (p = 0.000) in patients with MACE compared with those without MACE. Two-vessel coronary artery disease (CAD) (p = 0.037) and the maximum creatinine kinase (max-CK) (p = 0.031) produced significant results in repeat percutaneous coronary intervention. The area under the ROC curve was found to be statistically significant for cardiac death and CABG. NT-proBNP is a useful predictor for 12-month MACEs among patients with NSTEMI and in those with heart failure. We propose that a new index incorporating NT-proBNP, max-CK, and CAD vessel will be useful as a prognostic indicator of MACEs in the future.

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Section: Discussionmentioning

confidence: 99%

Biomarker for the Prediction of Major Adverse Cardiac Events in Patients with Non-ST-Segment Elevation Myocardial Infarction

Shon

Bae

Kim

et al. 2017

Osong Public Health Res Perspect

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“…Castro et al 14. divided 87 patients with non-ST-segment elevation acute coronary syndrome into two groups: 37 (42.5%) with unstable angina and 50 (57.5%) with non-ST-segment elevation myocardial infarction.…”

Section: Other Heart Diseasesmentioning

confidence: 99%

Diagnostic and prognostic values of B-type natriuretic peptides (BNP) and N-terminal fragment brain natriuretic peptides (NT-pro-BNP) : review article

Maries¹,

Manițiu²

2013

CVJA

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B-type natriuretic peptide (BNP) is a member of a four-natriuretic peptide family that shares a common 17-peptide ring structure. The N-terminal fragment (NT-pro-BNP) is biologically inert, but both are secreted in the plasma in equimolar quantities and both have been evaluated for use in the management of congestive heart failure. BNP and NT-pro-BNP are frequently used in the diagnosis of congestive heart failure and distinguishing between patients with dyspnoea of cardiac or pulmonary origin. Values of NT-pro-BNP are affected by age or the presence of one or several co-morbidities such as chronic renal failure, type 2 diabetes, and acute coronary syndrome. ‘Normal’ values of these peptides also vary depending on the type of test used. The performance characteristics of these tests vary depending on the patients on whom they are used and the manufacturer. For this reason, the determination of reference values for this peptide represents such a challenge.

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N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction

Shon

Hwang

Bae

et al. 2013

J. Cent. South Univ.

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Nível de NT-proBNP em pacientes com síndrome coronariana aguda sem supradesnivelamento do segmento ST

Abstract: Background: Non-ST-segment elevation acute coronary syndrome is associated with elevation of brain natriuretic peptide and markers of myocardial necrosis, although its relationship with the TIMI score and left ventricular function are largely unknown.

Cited by 6 publications

References 38 publications

Biomarker for the Prediction of Major Adverse Cardiac Events in Patients with Non-ST-Segment Elevation Myocardial Infarction

Biomarker for the Prediction of Major Adverse Cardiac Events in Patients with Non-ST-Segment Elevation Myocardial Infarction

Diagnostic and prognostic values of B-type natriuretic peptides (BNP) and N-terminal fragment brain natriuretic peptides (NT-pro-BNP) : review article

N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction

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