Left ventricular remodelling in patients with moderate systolic dysfunction after myocardial infarction: favourable effects of exercise training and predictive role of N-terminal pro-brain natriuretic peptide

Abstract

Six month ET induced a favourable LV remodelling and a marked fall in NT-proBNP that could predict LV remodelling in postinfarction patients with moderate LV dysfunction.

Favourable effects of exercise-based Cardiac Rehabilitation after acute myocardial infarction on left atrial remodeling

“…The present study also confirmed the favourable effects of exercise-based CR on LV remodeling and function showed in previous studies in patients with previous AMI or CHF and more severe compromise of LV systolic function [11][12][13][14][15], and in postinfarction patients with only mild to moderate LV dysfunction [16].…”

“…Atrial fibrillation complicating AMI has adverse prognostic implications [10] and it is associated to a larger LA size [3]. It has been widely shown that exercise-based Cardiac Rehabilitation (CR) after AMI has beneficial effects on LV remodeling [11][12][13] and may even reverse this process in some patients with chronic LV dysfunction [14][15][16]. Exercise-based CR is also associated with reduced mortality in postinfarction patients [17].…”

Clinical characteristics and course of patients with diabetes entering cardiac rehabilitation

“…Mounting evidence suggests that exercise training alone or as core component of cardiac rehabilitation (CR) programs has several beneficial effects reducing mortality [1], preventing cardiac remodeling [2,3], and improving cardiovascular functional capacity and myocardial perfusion [4][5][6][7]. The improvement of endothelial function [8], the anti-inflammatory properties [9,10], the improvement of neurohormonal and autonomic balance [11][12][13][14][15], and the reduction of oxidative stress [16] might be some of the putative mechanisms by which exercise training exerts its beneficial effects.…”

Influence of aerobic exercise training on left ventricular remodeling and neurohumoral response in patients with myocardial infarction

“…did not observed changes of BNP and proBNP plasma levels, after aerobic training of moderate intensity. Giallauria et al [21,28], showed a decrease of NT-proBNP circulating levels after three months of moderateintensity aerobic training, in patients with ventricular dysfunction after MI. Our data show that moderate-intensity aerobic training does not interfere with the natural course of NT-proBNP plasma level decrease, which usually occurs in the context of MI, associated to VR, as reported by Nagaya et al [29].…”