Favourable effects of exercise-based Cardiac Rehabilitation after acute myocardial infarction on left atrial remodeling

Cardiopulmonary exercise testing in the early-phase of myocardial infarction

“…In our study, we observed that the AMIG showed lower aerobic functional capacity both in the AT and at peak exercise compared to the CG, demonstrated by the power, HR, VO 2 30 and Tabet et al 33 . The lowest functional capacity values presented by AMIG, in both at the AT and at peak exercise, can be attributed to two distinct mechanisms: 1) the presence of pathology and 2) to the use of betablocker therapy.…”

“…In this way, the results suggest that both groups evaluated did not present reduced pulmonary perfusion capability and cardiac output, since this variable present a significant correlation with preserved function of mecanorreceptores and ergorreceptores, thereby contributing to the normal respiratory test response to exercise. However, in the study of Giallauria et al 30 in patients after 36 days of AMI, the relationship of VE/VCO 2 was 33.80±4.00. These results differ from those observed in our study.…”

“…These drugs improve survival and reduce hospitalization in this group of patients, and its action on exercise tolerance is still contradictory 30,33,43,42 . The beta-blockers are able to partially antagonize the sympathetic activity, which reduces HR, the myocardial oxygen consumption and increases the time of left ventricular filling, with improve myocardial perfusion 44 .…”

“…The slope VE/VCO 2 was calculated by linear regression models, from the beginning of increase of power during the test until the peak of exercise, using the values of the increased minute ventilation in relation to the carbon dioxide production, obtained during the CPET 30 . The OUES, which represents the relation between VO 2 and VE during the incremental exercise test, was calculated by logarithm expression of ventilation, in which OUES is defined as the regression slope "a" in VO 2 =a.logVE+b.…”

Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure: Part I

“…Sarà inoltre focalizzata l'attenzione su alcuni effetti che i training di esercizio fisico, da soli o inseriti come componenti della riabilitazione cardiologica hanno su alcune di questi nuove strategie. È dimostrato infatti che la riabilitazione cardiologica ha effetti benefici proprio nel prevenire il remodeling cardiaco [12,13], oltre che nel migliorare la performance cardiovascolare e la perfusione miocardica in pazienti affetti da cardiopatia ischemica cronica [14][15][16][17]. Diversi sono i meccanismi attraverso i quali l'esercizio fisico esercita i suoi effetti benefici: migliora la funzione endoteliale [18], ha proprietà anti-infiammatorie [19,20], miglioramento dell'imbalance autonomico [21][22][23][24][25] e la dimostrata riduzione dello stress ossidativo [26].…”