Left ventricular geometry and periodontitis in patients with the metabolic syndrome

Nibali, Luigi; Donos, Nikos; Terranova, V.; Pino, Antonino Di; Marca, Salvatore Di; Ferrara, Viviana; Pisano, Marcella; Purrello, Francesco; Rabuazzo, Agata Maria; Malatino, Lorenzo

doi:10.1007/s00784-018-2667-8

Cited by 13 publications

(6 citation statements)

References 38 publications

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“…37 Recently, it has been reported that relative wall thickness (RWT) is independently associated with severe periodontitis in patients with metabolic syndrome. 38 In the present study, there were 18.3% of subjects with metabolic syndrome and no significant difference in RWT existed between the subgroups with or without generalized severe periodontitis. Further investigation is required to clarify this point.…”

Section: Overall Abnormal Test Resultscontrasting

confidence: 49%

“…It should be noted that a 10‐year retrospective study reveals that the survival rate may decrease in the patients with diastolic dysfunction and normal EF 37 . Recently, it has been reported that relative wall thickness (RWT) is independently associated with severe periodontitis in patients with metabolic syndrome 38 . In the present study, there were 18.3% of subjects with metabolic syndrome and no significant difference in RWT existed between the subgroups with or without generalized severe periodontitis.…”

Section: Discussionmentioning

confidence: 41%

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Periodontitis links to concurrent systemic comorbidities among ‘self‐perceived health’ individuals

Zhao¹,

et al. 2022

J of Periodontal Research

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Background and Objective Our recent work shows that periodontitis experience reflects host susceptibility to the onset of multiple systemic diseases and conditions. This cross‐sectional study further investigated whether and to what extent the existing periodontitis could reflect the concurrent presence of inflammatory comorbidities among ‘self‐perceived health’ individuals. Materials and Methods There were 115 ‘self‐perceived health’ adults who completed a questionnaire on demographic characteristics and lifestyles. Twenty medical diagnostic tests were then performed to detect eight common systemic diseases and conditions. Meanwhile, full‐mouth periodontal examination was undertaken, and the subjects were classified as two subgroups with or without Generalized Severe Periodontitis (Stages III/IV, generalized). The interlink of periodontal status and concurrent systemic comorbidities was assessed. Results 98.3% (113/115) of the subjects exhibited at least one undiagnosed systemic disease/disorder. Of them, 52.2% (59/113) and 47.8% (54/113) concurrently presented with 1–5 or ≥6 abnormal test results, respectively. Overall, 96.5% (111/115) had periodontitis. Generalized Severe Periodontitis was present in 43.2% (48/111) of the periodontitis patients, and it was significantly associated with the profiles of abnormal test results after adjusting potential confounders (abnormal test results 1–5 vs ≥6; OR: 3.23, p = .012). Conclusions The present study shows that existing severe periodontitis could well reflect the concurrent presence of multiple inflammatory comorbidities. Oral and medical professionals can play proactive roles in enhancing health awareness and healthcare, through strong collaboration and teamwork.

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Section: Overall Abnormal Test Resultscontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 41%

Periodontitis links to concurrent systemic comorbidities among ‘self‐perceived health’ individuals

Zhao¹,

et al. 2022

J of Periodontal Research

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“…In accordance, it has also been shown that suPAR, during periodontitis, is highly expressed in macrophages, monocytes, and T‐lymphocytes 53 and also has been demonstrated to be an inducer of endothelial cell production 54 . In this regard, the presence of periodontitis and the related burden of periodontal bacteria could represent one of the trigger factors in the risk development of CVD and CHD 55–58 . Moreover, in patients with CVD, suPAR together with hs‐CRP, fibrin degradation products, and heat shock proteins, has been proven to have a key role in mediating the immune response on the endothelial wall and at stimulating the production of T‐reactive cells that have been shown to be useful subclinical earlier predictors of CHD and myocardial infarction 59 …”

Section: Discussionmentioning

confidence: 90%

Independent impact of periodontitis and cardiovascular disease on elevated soluble urokinase‐type plasminogen activator receptor (suPAR) levels

Isola

Polizzi

Alibrandi

et al. 2020

Journal of Periodontology

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Background Previous studies have demonstrated that a soluble urokinase‐type plasminogen activator receptor (suPAR) plays an essential function in leukocytes and endothelial homeostasis and, therefore, in the development of coronary heart disease (CHD) and periodontitis. The aim of this study was to analyze the impact of gingival health, periodontitis, and CHD on suPAR levels in plasma and saliva and to evaluate suPAR as a biomarker of periodontitis and CHD. Methods Healthy controls (n = 33), patients with periodontitis (n = 31), CHD (n = 29), and a combination of periodontitis + CHD (n = 29) were enrolled in the present study. All patients were clinically and periodontally evaluated and regularly assessed for socioeconomic status, serum lipids, high‐sensitivity C‐reactive protein (hs‐CRP), and for plasma and salivary suPAR levels. Results Patients with periodontitis (P <.001) and with periodontitis + CHD (P <.001) presented higher median plasma and salivary suPAR levels compared with CHD and healthy controls. Moreover, univariate regression analysis demonstrated that hs‐CRP (P <.001) and periodontitis (P <.001) had a significant negative direct effect on both plasma and salivary suPAR levels. The multivariate regression analysis showed that periodontitis was the only significant predictor of plasma suPAR (P = .035) while hs‐CRP was the only significant predictor of salivary suPAR (P <.001). Conclusions The results of the present study demonstrated that patients with periodontitis and periodontitis + CHD presented higher suPAR levels in both plasma and saliva in comparison with healthy controls and CHD. Moreover, periodontitis and hs‐CRP were the only significant predictors of the augmented suPAR levels in plasma and saliva, respectively.

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“…In fact, it has also been shown that Galectin‐3, during periodontitis or periapical lesions, is highly expressed in different cell lines such as toll‐like receptor‐2 and −4 45 or oral epithelial cells 13 as a key modulator of the inflammatory response. For the above hypotheses, the presence of periodontitis and its related burden of periodontal bacteria 46 could represent one trigger risk factor of CHD 47,48 through a specific mechanism that stimulates T‐reactive cells’ production on the endothelial walls and that may precede CHD and endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Analysis of galectin‐3 levels as a source of coronary heart disease risk during periodontitis

Isola

Polizzi

Alibrandi

et al. 2021

J of Periodontal Research

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Background and Objective Different evidence has shown that Galectins have a key role as modulators of cell surface functions and signaling in a wide range of inflammatory diseases during their preclinical stages. The aim of this study was to analyze the association and impact of periodontitis and coronary heart disease (CHD) on salivary and serum Galectin‐3 in patients with periodontitis and CHD. Materials and Methods For the present study, healthy controls (n = 38), periodontitis (n = 40), CHD (n = 39), and a combination of periodontitis +CHD (n = 38) patients were enrolled and analyzed. In each patient, demographic characteristics and a full‐mouth clinical periodontal examination were achieved. Moreover, serum and salivary samples were collected to assess Galectin‐3 and Endothelin‐1 (ET‐1) levels. The Jonckheere‐Terpstra p‐trend and Spearman's correlation tests as well as uni‐ and linear regression analyses were used to analyze the study data. Results Patients with periodontitis (serum, p = .003; saliva, p < .001) and periodontitis + CHD groups (serum p = .004; saliva, p < .001) had higher median serum and salivary concentrations of Galectin‐3 in comparison with CHD and healthy controls. Serum (p = .006) and salivary (p = .009) Galectin‐3 levels were significantly correlated with serum ET‐1. The multivariate regression analysis highlighted that periodontitis (p = .047) was the significant predictor of serum Galectin‐3 levels while ET‐1 (p = .028) was the significant predictor of salivary Galectin‐3 levels. Conclusion The results showed that patients with periodontitis and periodontitis + CHD presented significant higher serum and salivary Galectin‐3 levels in comparison with CHD patients and healthy subjects. Periodontitis and ET‐1 were the significant predictors of serum and salivary Galectin‐3 levels, respectively.

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Left ventricular geometry and periodontitis in patients with the metabolic syndrome

Cited by 13 publications

References 38 publications

Periodontitis links to concurrent systemic comorbidities among ‘self‐perceived health’ individuals

Periodontitis links to concurrent systemic comorbidities among ‘self‐perceived health’ individuals

Independent impact of periodontitis and cardiovascular disease on elevated soluble urokinase‐type plasminogen activator receptor (suPAR) levels

Analysis of galectin‐3 levels as a source of coronary heart disease risk during periodontitis

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