Periodontitis links to concurrent systemic comorbidities among ‘self‐perceived health’ individuals

Abstract

Background and Objective Our recent work shows that periodontitis experience reflects host susceptibility to the onset of multiple systemic diseases and conditions. This cross‐sectional study further investigated whether and to what extent the existing periodontitis could reflect the concurrent presence of inflammatory comorbidities among ‘self‐perceived health’ individuals. Materials and Methods There were 115 ‘self‐perceived health’ adults who completed a questionnaire on demographic characteristics and lifestyles. Twenty medical diagnostic tests were then performed to detect eight common systemic diseases and conditions. Meanwhile, full‐mouth periodontal examination was undertaken, and the subjects were classified as two subgroups with or without Generalized Severe Periodontitis (Stages III/IV, generalized). The interlink of periodontal status and concurrent systemic comorbidities was assessed. Results 98.3% (113/115) of the subjects exhibited at least one undiagnosed systemic disease/disorder. Of them, 52.2% (59/113) and 47.8% (54/113) concurrently presented with 1–5 or ≥6 abnormal test results, respectively. Overall, 96.5% (111/115) had periodontitis. Generalized Severe Periodontitis was present in 43.2% (48/111) of the periodontitis patients, and it was significantly associated with the profiles of abnormal test results after adjusting potential confounders (abnormal test results 1–5 vs ≥6; OR: 3.23, p = .012). Conclusions The present study shows that existing severe periodontitis could well reflect the concurrent presence of multiple inflammatory comorbidities. Oral and medical professionals can play proactive roles in enhancing health awareness and healthcare, through strong collaboration and teamwork.

Prevalence of Periodontal Disease among Patients at the Outpatient Clinic of Internal Medicine in an Academic Hospital in The Netherlands: A Cross-Sectional Pilot Study

“…So far, few studies investigated whether the number of systemic conditions in multimorbidity patients is associated with periodontal health status. One study conducted in Hong Kong did investigate whether periodontal health status reflects the concurrent presence of eight common systemic comorbidities using full-mouth periodontal examination, self-perceived health status questionnaires and 20 medical diagnostic tests [ 38 ]. It showed that those with worse periodontal conditions presented with poorer diagnostic test results and suffered from more systemic conditions.…”

“…It showed that those with worse periodontal conditions presented with poorer diagnostic test results and suffered from more systemic conditions. However, when comparing the comorbidity profiles with the severity of PD, most of them were not significant [ 38 ]. An Austrian study also indicated no association between the number of systemic conditions and the severity of PD [ 36 ].…”

“…On the other hand, the Hong Kong study did have a small patient cohort ( n = 115)—three times smaller than this study ( n = 345). However, an Austrian study, using a population cohort of 1119 patients, did not find an association between number of conditions and severity of PD [ 36 , 38 ] either. Secondly, the mean BMI in this study was 26.8 kg/m 2 (±11.3), which, according to the World Health Organization, is not within the normal range (i.e., BMI 18.5 to 24.99 kg/m 2 ) [ 39 ].…”

The Effects of 810 nm Diode Laser and Indocyanine Green on Periodontal Parameters and HbA1c in Patients with Periodontitis and Type II Diabetes Mellitus: A Randomized Controlled Study

“…A number of local and systemic factors can influence either the retention of periodontopathogenic bacterial plaque, with changes in its quantity and quality, or the ability of the immune system to effectively counteract bacterial aggression [ 3 ]. The latter include diabetes mellitus (DM).…”

Hermansky-Pudlak syndrome type 2: A rare cause of severe periodontitis in adolescents—A case study

“…Periodontitis is one of the prominent manifestations of some systemic diseases and is affected by systemic factors. Some systemic diseases can affect the resistance to bacteria, thus greatly increasing the susceptibility to periodontitis ( 14 ). Due to neutropenia and impaired platelet function, many HPS-2 patients, especially young children have gingival bleeding ( 11 , 15 – 18 ).…”