Analysis of galectin‐3 levels as a source of coronary heart disease risk during periodontitis

Isola, Gaetano; Polizzi, Alessandro; Alibrandi, Angela; Williams, Ray C.

doi:10.1111/jre.12860

Cited by 72 publications

(68 citation statements)

References 50 publications

(50 reference statements)

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“…The literature now recognises the link between cardiovascular disease and periodontal disease [ 58 , 59 ]. However, the pathophysiological links between these two diseases are still not entirely clear.…”

Section: Mirna As a Possible Link Between Periodontal Disease And Various Systemic Disordersmentioning

confidence: 99%

The Emerging Role of microRNA in Periodontitis: Pathophysiology, Clinical Potential and Future Molecular Perspectives

Santonocito

Polizzi

Palazzo

et al. 2021

IJMS

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During the last few decades, it has been established that messenger ribonucleic acid (mRNA) transcription does not inevitably lead to protein translation, but there are numerous processes involved in post-transcriptional regulation, which is a continuously developing field of research. MicroRNAs (miRNAs) are a group of small non-coding RNAs, which negatively regulate protein expression and are implicated in several physiological and pathological mechanisms. Aberrant expression of miRNAs triggers dysregulation of multiple cellular processes involved in innate and adaptive immune responses. For many years, it was thought that miRNAs acted only within the cell in which they were synthesised, but, recently, they have been found outside cells bound to lipids and proteins, or enclosed in extracellular vesicles, namely exosomes. They can circulate throughout the body, transferring information between cells and altering gene expression in the recipient cells, as they can fuse with and be internalised by the recipient cells. Numerous studies on miRNAs have been conducted in order to identify possible biomarkers that can be used in the diagnosis of periodontal disease. However, as therapeutic agents, single miRNAs can target several genes and influence multiple regulatory networks. The aim of this review was to examine the molecular role of miRNAs and exosomes in the pathophysiology of periodontal disease and to evaluate possible clinical and future implications for a personalised therapeutical approach.

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Section: Mirna As a Possible Link Between Periodontal Disease And Various Systemic Disordersmentioning

confidence: 99%

The Emerging Role of microRNA in Periodontitis: Pathophysiology, Clinical Potential and Future Molecular Perspectives

Santonocito

Polizzi

Palazzo

et al. 2021

IJMS

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“…When it is not managed or ineffectively managed, it conducts progressive tissue-attachment damage, bone resorption and tooth mobility. 2,3 Worthy to be mentioned that periodontal health transgresses the boundaries of the oral cavity and its correlation with numerous systemic diseases have been documented, particularly endocrine diseases, chronic kidney diseases and cardiovascular diseases. 2,3 Besides, obesity, stress and smoking were reported to be highly contributed to the progression of PD.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Worthy to be mentioned that periodontal health transgresses the boundaries of the oral cavity and its correlation with numerous systemic diseases have been documented, particularly endocrine diseases, chronic kidney diseases and cardiovascular diseases. 2,3 Besides, obesity, stress and smoking were reported to be highly contributed to the progression of PD. 4 Through the pathogenesis of PD, anaerobic gram-negative bacteria such as P. gingivalis, T. forsythia, P. intermedia and their bacterial products, lipopolysaccharide (LPS) or endotoxin trigger the immune reactions, 1 inducing the periodontal tissue inflammation process.…”

Section: Introductionmentioning

confidence: 99%

Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review

Dhaifullah¹,

Seayed²,

Mostafa³

et al. 2021

JEP

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Background: Recently, pharmacologic approaches have been seen in utilizing matrix metalloproteinase inhibitors (MMP-I) to prohibit the destruction of connective tissue accompanied by erythrogenic inflammatory diseases such as periodontitis. However, curcumin characteristics have been described to be effective in reducing inflammatory mediators and matrix metalloproteinase (MMP). But, due to its poor solubility and bioavailability, a chemically modified curcumin (CMC 2.24) has been used. Objective: The purpose of this research is to review and analyze the animal attempts which investigate the impact of CMC2.24 on periodontitis. Materials and Methods: Our study was based on reviewing the English preclinical studies using CMC2.24 on an induced periodontal disease which were published up to 2020, only randomized control trials (RCTs) were included. Databases were used from electronic websites including PubMed, ScienceDirect, and Google scholar. Results: Seven experimental trials involving 162 rats and 8 dogs were included in the present systematic review. Six studies investigated LPS-induced experimental periodontitis, two of them worked on diabetes-associated periodontitis, while one study worked on naturally occurring periodontitis. All included studies revealed that CMC 2.24 reduced alveolar bone loss as well as inhibited the MMP. Conclusion: Collectively, we concluded that CMC 2.24 has significant implications in prohibiting the progression of bone loss.

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“…Periodontitis and ET-1 were the significant predictors of serum and salivary galectin-3 levels, respectively. [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Macrovascular and Microvascular Hemodynamics Assessed by Spectrophotometry in Periodontal Diseases

Figliuzzi

Sestito

Pacifico

et al. 2021

International Journal of Dentistry

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Objective. The aim of this study is to identify a possible link between macrovascular hemodynamic status and microvascular hemodynamic indices in patients with periodontal disease. Methods and Materials. Seventeen adult patients are recruited on a voluntary basis at the Dentistry Department of the “Mater Domini” University of Catanzaro, with sampling that determines the lipid profile, blood glucose, inflammatory mediators, blood plasma viscosity: anamnesis, blood pressure measurement, and detection of anthropometric parameters: eco-Doppler of the carotid arteries and brachial arteries with noninvasive measurements of hemodynamics and evaluation of inflammation and periodontal circulation with a noninvasive spectroscopic technique. The subjects underwent a dental inspection with periodontal proves. The different indices of periodontal disease were evaluated. Results. The sites with high probing depth differ from the healthy ones, showing low oxygen saturation and a notable increase in tissue edema, but no correlation between macro- and microvascular values was found. Conclusion. Periodontal probing and spectroscopic examination showed the correlation between low oxygen saturation levels and tissue edema values with probing depth; however, no correlation between macrovascular hemodynamic status and microvascular hemodynamics indices was found probably given the heterogeneity of the population under consideration, the low number of data gathered, and the small sample size.

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Analysis of galectin‐3 levels as a source of coronary heart disease risk during periodontitis

Cited by 72 publications

References 50 publications

The Emerging Role of microRNA in Periodontitis: Pathophysiology, Clinical Potential and Future Molecular Perspectives

The Emerging Role of microRNA in Periodontitis: Pathophysiology, Clinical Potential and Future Molecular Perspectives

Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review

Relationship between Macrovascular and Microvascular Hemodynamics Assessed by Spectrophotometry in Periodontal Diseases

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