Leclercia adecarboxylata Sepsis and Cerebral Herniation

Sethi, Karen; Barker, Eric M; Metlay, Leon A.; Caserta, Mary T.; Daugherty, L. Eugene

doi:10.1093/jpids/pis131

Cited by 9 publications

(21 citation statements)

References 8 publications

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“…Our first case is presented to raise awareness of L. adecarboxylata in pediatric infections and to demonstrate its emerging presence even among those who are immunocompetent. End-stage renal disease Peritoneal fluid None Fattal and Deville [9] Premature birth Blood None Myers et al [10] Premature birth Blood None Nelson et al [11] Acute lymphoblastic leukemia Blood Staphylococcus aureus Longhurst and West [12] Leukopenia and neutropenia Blood None Sethi et al [14] Acute lymphoblastic leukemia Cellulitis None Shah et al [15] To our knowledge, the second case is the first published L. adecarboxylata UTI in a pediatric patient. L. adecarboxylata infections have been reported in the adult population after foreign body placements such as a central line or a peritoneal catheter [16,17].…”

Section: Discussionmentioning

confidence: 93%

“…This suspicion was further supported by his uncontrolled UTI resulted from medication non-compliance and possibly inadequate immune response secondary to CKD. We know from past reports that L. adecarboxylata can act as an opportunistic pathogen for the immunocompromised individuals, with one case where mortality was observed in an immunocompromised pediatric patient [13,14]. CKD has been known for its association with acquired immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

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Leclercia adecarboxylata: An Emerging Pathogen Among Pediatric Infections

Keyes¹,

Johnson²,

Epelman³

et al. 2020

Cureus

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Leclercia adecarboxylata is a gram-negative bacillus of the Enterobacteriaceae family. It is a rare human pathogen that is often acquired via wound and/or contact with aquatic environment. Although multiple cases of L. adecarboxylata infections are described in the adult population, few have been documented in pediatrics. We will present two cases of L. adecarboxylata infections in the pediatric population. The first is a case of cellulitis in an 11-year-old male patient after a penetrating wound. The second is a first-documented urinary tract infection in a 16-year-old male patient with chronic kidney disease. Both patients were successfully treated with antibiotics and surgical intervention, if necessary. These cases highlight the growing emergence of this bacterium in the pediatric population and the need to become more aware of its threat even in patients who are immunocompetent.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Leclercia adecarboxylata: An Emerging Pathogen Among Pediatric Infections

Keyes¹,

Johnson²,

Epelman³

et al. 2020

Cureus

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“…One child with colonic neuropathy and pseudo-obstruction acquired LAD infection, culminating into LAD sepsis. 9 Another case who expired was a preterm, very low birth weight baby who had LAD sepsis and succumbed on day 54 of life in spite of receiving sensitive antibiotics for 21 days. 10 No case of LAD causing SBP in NS has been reported so far, although one case of peritonitis has been reported from the West in a 5-year-old boy, who was on chronic peritoneal dialysis for end-stage renal disease.…”

Section: Discussionmentioning

confidence: 99%

Leclercia adecarboxylata Causing Spontaneous Bacterial Peritonitis in a Child with Nephrotic Syndrome: A Case Report and Review of Literature

et al. 2020

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Infection is an important complication of childhood nephrotic syndrome (NS) and spontaneous bacterial peritonitis (SBP) is a frequently encountered one. We present a 7-year-old boy with NS who had decreased urine output, generalized body swelling, and abdominal pain. Urine analysis showed proteinuria of 50 mg/m2/d. Ascitic tap showed total leukocyte count of 100 cells/mm3, sugar of 67 mg/dL, and protein of 1.1 g/dL. Gram stain revealed gram-negative bacilli with pus cells and culture grown Leclercia adecarboxylata (LAD). LAD was identified using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) with an identification score of 2.0. The organism showed good susceptibility to common antibiotics. The boy had no direct contact with livestock and the source of infection remains speculative. Devitalized skin because of massive edema seems to be the most plausible site of entry for the organism. Our patient was started on ceftriaxone and improved. LAD is a rare opportunistic pathogen, which belongs to Enterobacteriaceae and usually causes soft tissue infections. As far as we know, this is the first case where it has caused peritonitis in a child with NS. We also reviewed other pediatric cases.

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“…Ayrıca sıklıkla periton diyalizine bağlı olarak peritonit etkeni olarak bildirilmiştir 8,9 . Bazı çalışmalarda yenidoğan sepsis nedeni olduğu bildirilmiştir 10,11 . Bizim olgumuzda olduğu gibi hemodiyaliz hastalarında s antral venöz kateter ilişkili bakteriyemi olguları da bildirilmiştir 3,12 .…”

Section: Olgu Sunumuunclassified

Catheter-Related Bacteremia Caused By Leclercia adecarboxylata: Case Report

Şafak¹,

Sezer²,

Yenigun³

2017

BSBD

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bsbd@balikesir.edu.tr www.bau-sbdergisi.com ÖZET Öncel eri Enteri k grup 41 veya Eschrechia adecarboxylata ol a ra k bi l i nen mi kroorga ni zma , 1962'den i tibaren Leclercia adecarboxylata ol arak adlandırılmıştır. Çeşitli çevresel kaynaklarda bul unan mikroorganizmanın kan, idrar, balgam, ya ra gibi farklı klinik örneklerden i zole edil di ği bi l dirilmiştir. Bu olgu, bilgilerimize göre ül kemi zden bi l di ri l en L. adecarboxylata'ya ba ğl ı i l k enfeks i yon ol ma s ı nedeni yl e s unul muştur.Son dönem kroni k böbrek yetmezl i ği ol a n di ya l i ze gi ren 85 ya şında ki erkek ha s ta , a teş şi ka yetiyle acil servi se başvurmuştur. La boratuva r tetkiklerinde beya z küre normal, CRP, üre ve krea tinin yüksek olarak ölçülmüştür. Ya tırılarak tedavisi planlanan hastadan kateter ve peri fer da mar yol undan kan kültürü alınmıştır. Ampirik olarak s eftri a ks on teda vi s i ne ba şl a nmıştır. Ka teterden alınan kan kültürü, perifer damar yol undan alınan kan kültüründen dört s a a t önce ol mak üzere her iki örnekten de BacT/Alert 3D (bioMerieux, Fransa) kan kültür ci hazında pozitif s i nyal alınmıştır. L. adecarboxylata ol arak tanımlanan bakteri a mikasin, gentamisin, s eftazidim, s eftriakson, siprofloksasin, i mipenem duya rl ı, a moks i s i l i n -kl a vul a ni k a s i t di rençl i ol a ra k bul unmuştur. Ka teterden alınan kan kültürü örneği dört s aat önce pozitiflik verdiğinden kateter i l i şki l i L. adecarboxylata'ya ba ğl ı ba kteri yemi ta nıs ı konul muştur. Anti bi yoti k duya rl ıl ık ra poruna göre s eftri a ks on duya rl ı bul unduğunda n teda vi 15 güne ta ma ml a nmıştır.E. coli'ye benzerliği nedeniyle s ıklıkla a tlanabileceğinden özel l i kl e fos fomi s i n di rençl i E. coli i zolatlarında, ileri biyokimyasa l a na l i zl erl e a yrımının ya pıl ma s ı gerekti ği düşünül müştür.Anahtar Kelimeler: Lecl erci a a deca rboxyl a ta , ka teter ka yna kl ı, ba kteri yemi SUMMARYThe mi croorganism known as Enteri c group 41 or Escherichia adecarboxylatain the pa s t wa s na med as Leclercia adecarboxylata s i nce 1962. It has been reported that the mi croorga ni s m, whi ch is present i n va rious environmenta l res ources wa s i s ol a ted from di fferent cl i ni ca l s pecimens s uch a s blood, urine, sputum and wound. This case report was presented, beca us e of the fa ct that i t is the first reported infection caused by L. adecarboxylata i n our country a s fa r a s we know.The ma le patient aged 85 yea rs old on di a l ys i s wi th end s ta ge chroni c rena l di s ea s e wa s a dmitted to emergency s ervice wi th complaint of fever. The laboratory a nalysis revealed hi gh l evels of CRP, urea a nd creatinin and normal levels of white blood cel l count. Bl ood cul tures were obtained vi a the catheter and periphera l va s cul a r a cces s , from the pa ti ent who wa s hos pitalised to plan the treatment. Ceftriaxone was s tarted as a n empi ri ca l trea tment. Both bl ood culture s amples were positive signalling i n Bact/Alert 3D (Biomeriuex, Fra nce) i n whi ch the one obtained f...

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Leclercia adecarboxylata Sepsis and Cerebral Herniation

Abstract: Leclercia adecarboxylata, a gram-negative bacillus of the Enterobacteriaceae family, is rarely identified as a pathogen in humans. We describe a fatal case of L adecarboxylata sepsis in a child. This is the first reported pediatric death associated with infection due to L adecarboxylata.

Cited by 9 publications

References 8 publications

Leclercia adecarboxylata: An Emerging Pathogen Among Pediatric Infections

Leclercia adecarboxylata: An Emerging Pathogen Among Pediatric Infections

Leclercia adecarboxylata Causing Spontaneous Bacterial Peritonitis in a Child with Nephrotic Syndrome: A Case Report and Review of Literature

Catheter-Related Bacteremia Caused By Leclercia adecarboxylata: Case Report

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