Leclercia adecarboxylata: An Emerging Pathogen Among Pediatric Infections

Abstract

Leclercia adecarboxylata is a gram-negative bacillus of the Enterobacteriaceae family. It is a rare human pathogen that is often acquired via wound and/or contact with aquatic environment. Although multiple cases of L. adecarboxylata infections are described in the adult population, few have been documented in pediatrics. We will present two cases of L. adecarboxylata infections in the pediatric population. The first is a case of cellulitis in an 11-year-old male patient after a penetrating wound. The second is a first-documented urinary tract infection in a 16-year-old male patient with chronic kidney disease. Both patients were successfully treated with antibiotics and surgical intervention, if necessary. These cases highlight the growing emergence of this bacterium in the pediatric population and the need to become more aware of its threat even in patients who are immunocompetent.

Seasonal plasticity and energy efficiency in migratory buntings is an assemblage of alterations in metabolic and gut microbe adaptations

“…Serratia marcescens reported to mediate oxidative lactic acid production and citrate degradation in gut, whereas Serratia nematodiphila utilizes lactate, l-ornithine and proline. (Zhang et al, 2009) Leclercia adecarboxylata (Keyes et al, 2020) utilizes malonate for carbon source and corroborates with our observation of lower malonate levels in nonM . Migratory bird faeces included 9 non-pathogenic species of Firmicutes i.e.…”

“…Bacteria identified from nonM bird faeces i.e. Raoultella ornithinolytica (Hajjar et al, 2020) , Serratia marcescens (Greenberg, 1978) , Leclercia adecarboxylata (Keyes et al, 2020) and Serratia nematodiphila (Zhang et al, 2009) were largely facultative anaerobic. Raoultella ornithinolytica is an important food regulator (Yoshimatsu et al, 2002), reduces birds’ appetite and might play role in lower food consumption during nonM (Jain & Kumar, 1995).…”

Colonisation of extended spectrum β-lactamase- and carbapenemase-producing bacteria on hospital surfaces from low-/middle-income countries

“…adecarboxylata has been implicated in paediatric infections and sepsis 44,45 ; however, it is normally found in water and food (Shaikhain et al, 2021). Although detection across all LMICs hospitals in this study was limited, the presence of this species with blaNDM emphasises a potential source of infection and should be monitored further.…”

Acinetobacter radioresistens and Enterococcus casseliflavus co-infection with endocarditis, bacteremia, and pneumonia

“…The presumed contaminant specimen, Leclercia adecarboxylata, is a rare motile, aerobic Gram-negative bacillus part of the Enterobacteriaceae family commonly found in waters, some animals, and the gastrointestinal tract [9] , [10] . Pathogenicity has been reported as an opportunistic infection commonly manifesting as cellulitis with rare cases of peritonitis and bacteremia in immunocompromised patients [9] , [10] .…”

“…The presumed contaminant specimen, Leclercia adecarboxylata, is a rare motile, aerobic Gram-negative bacillus part of the Enterobacteriaceae family commonly found in waters, some animals, and the gastrointestinal tract [9] , [10] . Pathogenicity has been reported as an opportunistic infection commonly manifesting as cellulitis with rare cases of peritonitis and bacteremia in immunocompromised patients [9] , [10] . Although only one blood culture obtained was positive for this, our patient was likely exposed to contaminated water by extension of his socioeconomic status which led to it being treated as a presumed contaminant.…”