Learning processing in the basal ganglia: A mosaic of broken mirrors

Cunha, Cláudio Da; Wietzikoski, Evellyn Claudia; Dombrowski, Patrícia A.; Bortolanza, Mariza; Santos, Lucélia Mendes dos; Boschen, Suelen Lúcio; Miyoshi, Edmar

doi:10.1016/j.bbr.2008.10.001

Cited by 48 publications

(31 citation statements)

References 210 publications

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“…CAR demands a mechanism by which an action can be triggered by a warning stimulus, and the striatum can provide such a mechanism (Da Cunha et al 2009). Its projection neurons receive inputs from almost all areas of the cortex where warning stimuli are encoded (McGeorge and Faull 1989;Voorn et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

Wietzikoski¹,

Boschen²,

Miyoshi

et al. 2011

Psychopharmacology

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Section: Discussionmentioning

confidence: 99%

Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

Wietzikoski¹,

Boschen²,

Miyoshi

et al. 2011

Psychopharmacology

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“…On the basis of clinical SRTT studies in which Parkinson's disease patients showed deficits in sequential learning (for review see Siegert et al, 2006) and imaging studies revealing striatal recruitment during sequential learning (e.g., Werheid et al, 2003;Badgaiyan et al, 2007), various models were proposed that suggest a crucial role for dopaminergic processes in the striatum in sequential learning (Graybiel, 1998;Doyon and Ungerleider, 2002;Packard and Knowlton, 2002;Da Cunha et al, 2009;Schwarting, 2009). In a recent series of experiments using our rat version of the SRTT (Domenger and Schwarting 2005, 2007, we were able to lend further empirical support to the models' notion of the dependency of sequential learning on striatal dopamine availability Schwarting, 2008, Eckart et al, 2010a,b).…”

Section: Introductionmentioning

confidence: 99%

Dorsal hippocampal lesions boost performance in the rat sequential reaction time task

2011

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It is commonly accepted that the hippocampus plays a major role in declarative memory across species and that it is of particular relevance for spatial memory in rodents. However, the interplay between hippocampal function and nondeclarative memory systems, such as procedural stimulus-response (S-R) or sequential learning, is less clear: depending on task requirements, an interaction, dissociation or interference between hippocampal function and other memory systems may occur. This study was conducted to investigate the influence of dorsal ibotenic hippocampal lesions on learning and performance of sequential behavior in a rat version of the serial reaction time task (SRTT). Magnetic resonance imaging (MRI) analyses of the lesions revealed a bilateral volume reduction of ≈ 46% (histological analyses: ≈ 59%) of the total hippocampus. They were largely confined to its dorsal part and led to an expected spatial memory deficits in an object place recognition test as compared to healthy controls, even though sham lesions had the same effect. Our earlier studies on sequential learning had revealed substantial impairments in case of dorsal striatal dopaminergic lesions. In the present study, however, hippocampal lesioned animals unexpectedly showed superior performance throughout SRTT testing and training as compared to controls, which resulted in a higher degree of subsequent automated sequential behavior. Thus, our data reveal the infrequent case where hippocampal lesions lead to long-term improvements in test performance of a type of rather complex procedural behavior. One possible explanation for this effect is that hippocampal activity in rodents can interfere with other memory systems during the acquisition of procedural tasks with very low spatial requirements, as used here. Alternative explanations for the observed superior SRTT performance in lesioned animals, such as hyperactivity or increased exploratory drive are also topic of the discussion.

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“…There is a myriad of theories about the role of the basal ganglia in learning and memory. In the interest of brevity, the reader is referred to the review articles that address research in animals and computational studies on long-term potentiation, depression and reinforcement learning (e.g., Da Cunha, et al, 2009;White, 1997). In a nutshell, the basal ganglia build stimulus-response mappings that provide the largest amount of reward.…”

Section: Memory: Seeing the Trees Through The Forestmentioning

confidence: 99%

Computational Investigations of Cognitive Impairment in Huntington's Disease

Davelaar¹

2012

Huntington's Disease - Core Concepts and Current Advances

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Learning processing in the basal ganglia: A mosaic of broken mirrors

Cited by 48 publications

References 210 publications

Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

Dorsal hippocampal lesions boost performance in the rat sequential reaction time task

Computational Investigations of Cognitive Impairment in Huntington's Disease

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