Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

Wietzikoski, Evellyn Claudia; Boschen, Suelen Lúcio; Miyoshi, Edmar; Bortolanza, Mariza; Santos, Lucélia Mendes dos; Frank, Michael J.; Brandão, Marcus Lira; Winn, Philip; Cunha, Cláudio Da

doi:10.1007/s00213-011-2384-3

Cited by 42 publications

(23 citation statements)

References 60 publications

(61 reference statements)

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“…Apparently, the response drive in the DLS that is acquired after overtraining renders drug seeking less sensitive to (more recently acquired) intermittent punishment-driven inhibition of responding. This interpretation is consistent with findings that implicate the DLS in instrumental responding based on foot shock avoidance (Wietzikoski et al, 2012). We speculate that the DLS may play a role in this process because of the lack of direct connectivity between threat related areas such as the amygdala and ventral hippocampus and the DLS (Killcross et al, 1997;Voorn et al, 2004).…”

Section: Discussionsupporting

confidence: 92%

Differential Roles of the Dorsolateral and Midlateral Striatum in Punished Cocaine Seeking

Jonkman¹,

Pelloux²,

Everitt³

2012

J. Neurosci.

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Continued instrumental drug seeking despite contingent punishment is a core phenotype of drug addiction. Although the neuroanatomical basis of punished drug seeking is unclear, we hypothesize that the sensorimotor striatum, a structure that mediates habitual drug seeking, also mediates punished cocaine seeking. Forelimb sensorimotor projections into the striatum of the rat extend from the dorsolateral to midlateral striatum. Here, we selectively inactivated the dorsolateral and midlateral striatum in rats responding for cocaine in a seeking-taking task. We inactivated both regions after the acquisition of cocaine seeking, after extended cocaine self-administration and finally after the introduction of intermittent, seeking-contingent foot shock. The results show that inactivation of the dorsolateral striatum selectively disrupted punished drug seeking but did not affect unpunished drug seeking, even after extended training. Inactivation of the midlateral striatum, on the other hand, disrupted drug seeking at all stages of training. The effect of inactivating the dorsolateral striatum under punishment conditions was present before delivery of the first shock in the session, and responding reverted to baseline the next day. Thus, inactivation of the dorsolateral striatum seems to enhance the influence of recalled threat of negative consequences of cocaine seeking. The proportional reduction in responding after inactivation of the dorsolateral striatum did not vary with the individual level of compulsivity. Together, these results suggest a novel differentiation of function in the sensorimotor striatum, where the dorsolateral striatum selectively mediates the rigidity of responding after overtraining, while the midlateral striatum mediates responding itself at all stages of training.

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Section: Discussionsupporting

confidence: 92%

Differential Roles of the Dorsolateral and Midlateral Striatum in Punished Cocaine Seeking

Jonkman¹,

Pelloux²,

Everitt³

2012

J. Neurosci.

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“…Although our experiments primarily focus on fear and reward extinction, Guarraci et al (1999) and others (Pezze and Feldon, 2004) have demonstrated that fear conditioning is also modulated by D1/5 receptor activation within specific brain regions. However, D1/5 receptor activation does not consistently enhance all types of aversive learning, as shown by Wietzikoski et al (2012) with systemic SKF 81297 in a conditioned avoidance task. Thus, D1/5 receptor activation may have a brain region-specific and task-specific role in fear, but may not generally promote all aversive learning.…”

Section: Discussionmentioning

confidence: 91%

Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors

Abraham

Neve

Lattal

2016

Neuropsychopharmacol

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Dopamine is critical for many processes that drive learning and memory, including motivation, prediction error, incentive salience, memory consolidation, and response output. Theories of dopamine's function in these processes have, for the most part, been developed from behavioral approaches that examine learning mechanisms in appetitive tasks. A parallel and growing literature indicates that dopamine signaling is involved in consolidation of memories into stable representations in aversive tasks such as fear conditioning. Relatively little is known about how dopamine may modulate memories that form during extinction, when organisms learn that the relation between previously associated events is severed. We investigated whether fear and reward extinction share common mechanisms that could be enhanced with dopamine D1/5 receptor activation. Pharmacological activation of dopamine D1/5 receptors (with SKF 81297) enhanced extinction of both cued and contextual fear. These effects also occurred in the extinction of cocaine-induced conditioned place preference, suggesting that the observed effects on extinction were not specific to a particular type of procedure (aversive or appetitive). A cAMP/PKA biased D1 agonist (SKF 83959) did not affect fear extinction, whereas a broadly efficacious D1 agonist (SKF 83822) promoted fear extinction. Together, these findings show that dopamine D1/5 receptor activation is a target for the enhancement of fear or reward extinction.

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“…Optogenetic inactivation of DA neurons in the SNc or VTA induces conditioned-place aversion (Ilango and et al, 2014). Studies have demonstrated impaired conditioned-avoidance learning in rats with SNc lesions induced by MPTP (Da Cunha et al, 2001; Gevaerd et al, 2001a, b; Perry et al, 2004; Bortolanza et al, 2010) or 6-OHDA (Cooper et al, 1973) and in rats with dorsal striatum lesions (Wendler et al, 2014), dorsal striatum DA depletion (Rane and King, 2011), and intra-dorsolateral striatum infusion of D1 (Wietzikoski et al, 2012) and D2 DA receptor antagonists (Boschen et al, 2011). A recent microdialysis study by Dombrowski et al (2013) found that during conditioned-avoidance learning, DA release in the striatum increased only in the first trials in which rats avoided footshocks but not after they had learned the task.…”

Section: Emerging Theories In Bg Mechanismmentioning

confidence: 99%

Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation

Cunha

Boschen

Gómez-A

et al. 2015

Neuroscience & Biobehavioral Reviews

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This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson’s disease, Huntington’s disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BG functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms.

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Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

Abstract: The results suggest that the D1-like receptors in the NAc and DLS play important, though different, roles in learning and performance of CAR.

Cited by 42 publications

References 60 publications

Differential Roles of the Dorsolateral and Midlateral Striatum in Punished Cocaine Seeking

Differential Roles of the Dorsolateral and Midlateral Striatum in Punished Cocaine Seeking

Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors

Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation

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