Learning in Year-Old Female Autoimmune BXSB Mice

Boehm, Gary W.; Sherman, Gordon F.; Hoplight, Blair J.; Hyde, Lynn A.; Bradway, Dawn M.; Galaburda, Albert M.; Ahmed, S. Ansar; Denenberg, Victor H.

doi:10.1016/s0031-9384(98)00027-4

Cited by 17 publications

(7 citation statements)

References 40 publications

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“…This indicated that it was the secondary thalamic changes and not the primary cortical malformations that were probably responsible for the changes in auditory task performance. The cortical changes themselves may be responsible for other behavioural anomalies seen in animals with malformations (Denenberg et al, 1988(Denenberg et al, , 1991Schrott et al, 1992;Boehm et al, 1996Boehm et al, , 1998Waters et al, 1997). Moreover, since females did not show the same response in the thalamus as the males to the inducing of ectopias in the cortex, it seems that they were protected in some way.…”

Section: Sex Differencesmentioning

confidence: 99%

Developmental dyslexia: a multilevel syndrome

Galaburda

1999

Dyslexia

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Section: Sex Differencesmentioning

confidence: 99%

Developmental dyslexia: a multilevel syndrome

Galaburda

1999

Dyslexia

Self Cite

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“…Ectopics also demonstrated better reference memory learning compared to nonectopics in a nonspatial intramaze cued version of the Morris maze (Hyde, 1998). Ectopics did not differ from nonectopics in learning a reference memory non-spatial-cued water T-maze task (Balogh et al, 1998;Boehm et al, 1998;Denenberg et al, 1996), but ectopics exhibited better 8-week retention of this task (Balogh et al, 1998). Similarly, ectopics had better 8-week retention of the spatial reference memory Morris maze task than nonectopics (Boehm et al, 1996a).…”

Section: Introductionmentioning

confidence: 82%

“…Although BXSB mice are inbred, only about half have ectopias (Balogh, Sherman, Hyde, & Denenberg, 1998;Boehm et al, 1998;Boehm et al, 1996a;Boehm et al, 1996b;Denenberg et al, 1991b;Denenberg et al, 1996;Hoplight et al, 2000;Hoplight et al, 2001;Hyde et al, 2000b;Sherman et al, 1987;Sherman et al, 1990a). This is advantageous for studying behavior since ectopic and nonectopic mice are genetically identical and only differ in the presence or absence of the ectopia(s).…”

Section: Introductionmentioning

confidence: 99%

“…In BXSB mice, ectopias are usually located in the prefrontal and/or motor region of cortex (Boehm et al, 1998;Boehm et al, 1996a;Boehm, Sherman, Rosen, Galaburda, & Denenberg, 1996b;Denenberg, Sherman, Schrott, Rosen, & Galaburda, 1991b;Hoplight, Sherman, Hyde, & Denenberg, 2001;Hyde, Sherman, Hoplight, & Denenberg, 2000b;Sherman et al, 1987;Sherman et al, 1990a;Waters, Sherman, Galaburda, & Denenberg, 1997). Although BXSB mice are inbred, only about half have ectopias (Balogh, Sherman, Hyde, & Denenberg, 1998;Boehm et al, 1998;Boehm et al, 1996a;Boehm et al, 1996b;Denenberg et al, 1991b;Denenberg et al, 1996;Hoplight et al, 2000;Hoplight et al, 2001;Hyde et al, 2000b;Sherman et al, 1987;Sherman et al, 1990a). This is advantageous for studying behavior since ectopic and nonectopic mice are genetically identical and only differ in the presence or absence of the ectopia(s).…”

Section: Introductionmentioning

confidence: 99%

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Effects of ectopias and their cortical location on several measures of learning in BXSB mice

Hyde

Hoplight

Harding

et al. 2001

Developmental Psychobiology

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About half of BXSB/MpJ-Yaa mice have ectopias, which are misplaced clusters of neurons located in layer I of cortex. This study replicated several previous findings showing that there are learning differences between mice with ectopias and those without. In addition, we had sufficient numbers of ectopic mice to investigate if ectopics learned differently depending on the cortical location of the ectopia(s). Mice with at least one ectopia located in prefrontal cortex were initially impaired in learning the Morris maze, as well as relearning the Lashley maze when it was inverted, but learned better in the radial-arm maze when compared to ectopic mice with ectopias located in nonprefrontal regions of cortex. Mice with at least one ectopia in motor cortex learned the Lashley maze better than mice with ectopias located outside motor cortex. In sum, the cortical location of the ectopia(s) affected learning performance in certain tasks within the ectopic group, but regardless of the cortical location of the ectopia(s), ectopics still learned differently than nonectopics in several tasks.

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“…The animals were maintained for a week in the housing room to habituate 14 , with water and food ad libitum, and under a normal 12:12h light/dark cycle (lights on 7:00h). All experimental procedures were approved by Ethics Committee on Animal Experimentation of Federal University of Juiz de Fora (protocol number 043/2009), and were consistent with the principles stated in Guide for care and use of laboratory animals 15 .…”

Section: Animalsmentioning

confidence: 99%