Learning and memory impairment induced by 1,4-butanediol is regulated by ERK1/2-CREB-BDNF signaling pathways in PC12 cells

Bu, Lingling; Liu, Huan; Rang, Yifeng; Huang, Huiying; Xiao, Xueman; Ou, Genghua; Liu, Chunhong

doi:10.1007/s11011-022-00963-0

Cited by 3 publications

(2 citation statements)

References 70 publications

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“…In the hippocampus of PSD rats, CREB/BDNF/TrkB signaling pathway activity is decreased, and depressive symptoms are aggravated. 69 The results also showed that acupuncture could improve the neurological function and depressive symptoms of PSD rats, decrease the oxidative stress level of hippocampal neural tissue, increase the expression of BDNF and CREB and the phosphorylation level of CREB, and regulate the CREB/BDNF/TrkB signaling pathway, which was consistent with the effect of antidepressant drugs. Reducing oxidative stress, increasing BDNF expression, and enhancing CREB/BDNF/TrkB signaling pathway activity are key to improving PSD symptoms.…”

Section: Acupuncturesupporting

confidence: 61%

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Sun,

Cao,

Xin

et al. 2024

IJGM

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Depression is a prevalent mental disorder and has a profound impact on an individual’s psychological and physical well-being. It is characterized by a persistently depressed mood, loss of interest, energy loss, and cognitive dysfunction. In recent years, more and more people have changed to mental diseases, such as depression, anxiety, mania and so on. In the incidence of depression, covering all ages, but still mainly young and middle-aged women. Traditional treatments for depression mainly rely on medication and psychotherapy, but these methods are not effective for all patients and are often accompanied by certain side effects. Therefore, finding safe and effective alternative or adjuvant treatments has become a priority. Here we highlight the research progress of acupuncture in the treatment of depression and to explore the mechanism of acupuncture in the treatment of depression. Acupuncture treatment of depression is an ancient and effective method, the mechanism involves multiple biological pathways, for example, by regulating neurotransmitter levels, regulating the neuroendocrine axis, improving neuroplasticity, anti-inflammatory and other effects, improving emotional state and play an antidepressant role. To provide evidence to support the widespread use of acupuncture in clinical practice. We hope to provide new treatment ideas and methods for patients with depression, and even reduce the incidence of depression.

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Section: Acupuncturesupporting

confidence: 61%

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Sun,

Cao,

Xin

et al. 2024

IJGM

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“…1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopaminergic neuronal damage in SAMP8 mice and learning and memory impairment, whereas environment enrichment directly increased GAP-43 expression in the substantia nigra of mice to protect dopaminergic neurons from MPTP injury [ 44 ]. Similarly, 1,4-butanediol is toxic to the nervous system and can reduce the expression of proteins such as GAP-43 through the ERK1/2-CREB-BDNF signaling pathway, affecting synaptic plasticity and inducing learning and memory impairments [ 45 ]. Thus, enhancement of neuronal synaptic plasticity by promoting GAP-43 expression levels is beneficial.…”

Section: Potential Mechanisms Underlying the Effects Of Acupuncture O...mentioning

confidence: 99%

Acupuncture Interventions for Alzheimer’s Disease and Vascular Cognitive Disorders: A Review of Mechanisms

Yang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Cognitive impairment (CI) related to Alzheimer’s disease (AD) and vascular cognitive disorders (VCDs) has become a key problem worldwide. Importantly, CI is a neuropsychiatric abnormality mainly characterized by learning and memory impairments. The hippocampus is an important brain region controlling learning and memory. Recent studies have highlighted the effects of acupuncture on memory deficits in AD and VCDs. By reviewing the literature published on this topic in the past five years, the present study intends to summarize the effects of acupuncture on memory impairment in AD and VCDs. Focusing on hippocampal synaptic plasticity, we reviewed the mechanisms underlying the effects of acupuncture on memory impairments through regulation of synaptic proteins, AD characteristic proteins, intestinal microbiota, neuroinflammation, microRNA expression, orexin system, energy metabolism, etc., suggesting that hippocampal synaptic plasticity may be the common as well as the core link underlying the above mechanisms. We also discussed the potential strategies to improve the effect of acupuncture. Additionally, the effects of acupuncture on synaptic plasticity through the regulation of vascular–glia–neuron unit were further discussed.

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