Dynamic regulation of BDNF gene expression by estradiol and lncRNA HOTAIR

Deb, Paromita; Chini, Avisankar; Guha, Prarthana; Rishi, Ashcharya; Bhan, Arunoday; Brady, Blake; Perrotti, Linda I.; Mandal, Subhrangsu S.

doi:10.1016/j.gene.2023.148055

Cited by 3 publications

(1 citation statement)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These receptors belong to the nuclear receptor superfamily and act as transcription factors. The primary regulation of gene expression involves direct binding of the receptor to EREs sequences as it is the case for example for progesterone receptor ( Pgr ) ( 37 ), Kiss-1 metastasis suppressor ( Kiss1 ) ( 38 ), dynorphin ( Dyn ) ( 39 ) and brain derived neurotrophic factor ( Bdnf ) ( 40 ). In addition to its slow genomic action, rapid effects of estradiol have been observed.…”

Section: Estrogen Receptors: Types and Neural Expressionmentioning

confidence: 99%

Reproductive function and behaviors: an update on the role of neural estrogen receptors alpha and beta

Torres,

Adam,

Mhaouty-Kodja

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

Infertility is becoming a major public health problem, with increasing frequency due to medical, environmental and societal causes. The increasingly late age of childbearing, growing exposure to endocrine disruptors and other reprotoxic products, and increasing number of medical reproductive dysfunctions (endometriosis, polycystic ovary syndrome, etc.) are among the most common causes. Fertility relies on fine-tuned control of both neuroendocrine function and reproductive behaviors, those are critically regulated by sex steroid hormones. Testosterone and estradiol exert organizational and activational effects throughout life to establish and activate the neural circuits underlying reproductive function. This regulation is mediated through estrogen receptors (ERs) and androgen receptor (AR). Estradiol acts mainly via nuclear estrogen receptors ERα and ERβ. The aim of this review is to summarize the genetic studies that have been undertaken to comprehend the specific contribution of ERα and ERβ in the neural circuits underlying the regulation of the hypothalamic-pituitary-gonadal axis and the expression of reproductive behaviors, including sexual and parental behavior. Particular emphasis will be placed on the neural role of these receptors and the underlying sex differences.

show abstract

Section: Estrogen Receptors: Types and Neural Expressionmentioning

confidence: 99%

Reproductive function and behaviors: an update on the role of neural estrogen receptors alpha and beta

Torres,

Adam,

Mhaouty-Kodja

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

Discovery and functional characterization of LncRNAs associated with inflammation and macrophage activation

Chini,

Guha,

Rishi

et al. 2024

Methods

View full text Add to dashboard Cite

The Role of Estrogen across Multiple Disease Mechanisms

Xiang,

Palasuberniam,

Pare

2024

CIMB

View full text Add to dashboard Cite

Estrogen is a significant hormone that is involved in a multitude of physiological and pathological processes. In addition to its pivotal role in the reproductive system, estrogen is also implicated in the pathogenesis of a multitude of diseases. Nevertheless, previous research on the role of estrogen in a multitude of diseases, including Alzheimer’s disease, depression, cardiovascular disease, diabetes, osteoporosis, gastrointestinal diseases, and estrogen-dependent cancers, has concentrated on a single disease area, resulting in a lack of comprehensive understanding of cross-disease mechanisms. This has brought some challenges to the current treatment methods for these diseases, because estrogen as a potential therapeutic tool has not yet fully developed its potential. Therefore, this review aims to comprehensively explore the mechanism of estrogen in these seven types of diseases. The objective of this study is to describe the relationship between each disease and estrogen, including the ways in which estrogen participates in regulating disease mechanisms, and to outline the efficacy of estrogen in treating these diseases in clinical practice. By studying the role of estrogen in a variety of disease mechanisms, it is hoped that a more accurate theoretical basis and clinical guidance for future treatment strategies will be provided, thus promoting the effective management and treatment of these diseases.

show abstract

Dynamic regulation of BDNF gene expression by estradiol and lncRNA HOTAIR

Cited by 3 publications

References 100 publications

Reproductive function and behaviors: an update on the role of neural estrogen receptors alpha and beta

Reproductive function and behaviors: an update on the role of neural estrogen receptors alpha and beta

Discovery and functional characterization of LncRNAs associated with inflammation and macrophage activation

The Role of Estrogen across Multiple Disease Mechanisms

Contact Info

Product

Resources

About