LDL-C/apoB and HDL-C/apoA-1 ratios predict incident chronic kidney disease in a large apparently healthy cohort

Bae, Ji Cheol; Han, Ji Min; Kwon, Sam Hyun; Jee, Jae Hwan; Yu, Tae Yang; Lee, Moon Kyu; Kim, Jae Hyun

doi:10.1016/j.atherosclerosis.2016.06.029

Cited by 30 publications

(18 citation statements)

References 41 publications

(57 reference statements)

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“…Although non-HDL-c/HDL-c is a well-studied risk factor for CVD [13-15], this study is one of the first reporting its association with kidney disease [26]. Our study is also one of the first to relate varying lipid parameters to kidney disease using the novel CKD-EPI equation, which is as accurate as the MDRD Study equation at GFR<60 ml/min/1.73 m 2 but is more accurate at higher GFRs [17].…”

Section: Discussionmentioning

confidence: 99%

“…observed varying non-HDL-c concentrations at different stages of albuminuria in type 1 diabetes and found that non-HDL-c was predictive of progression to end-stage renal disease (ESRD). Bae et al [45]. showed that higher non-HDL-c/HDL-c, but not non-HDL-c, was associated with a higher risk of incident CKD in a large and apparently healthy cohort.…”

Section: Discussionmentioning

confidence: 99%

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Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Wen

Chen

Huang

et al. 2017

Kidney Blood Press Res

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Background/Aims: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. Methods: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m² or dipstick-positive proteinuria. Logistic regression models were used to examine the relationship between lipid variables and CKD. Results: The prevalence of CKD in this study was 3.7%. When the participants exhibited higher serum triglyceride (TG), a higher TG/high-density lipoprotein cholesterol (TG/HDL-c) ratio or a higher non-HDL-c/HDL-c ratio or HDL-c in a lower quartile, the prevalence of CKD tended to be higher. The multivariate adjusted odds ratios for CKD per 1 standard deviation increase in lipid level were 1.17 (1.10-1.23) for TG, 0.86 (0.79-0.93) for HDL-c, 1.21 (1.13-1.31) for the TG/HDL-c ratio, and 1.14 (1.06-1.22) for the non-HDL-c/HDL-c ratio. No significant association was detected between CKD and total cholesterol (TC), non-HDL-c or the low-density lipoprotein cholesterol/HDL-c (LDL-c/HDL-c) ratio. Conclusion: In this relatively healthy adult Chinese population, the CKD-EPI equation determined that the TG/HDL-c and non-HDL-c/HDL-c ratios as well as TG and HDL-c correlate with the prevalence of CKD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Wen

Chen

Huang

et al. 2017

Kidney Blood Press Res

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“…The increase of one standard deviation of TG level and TG/HDL-cholesterol ratio was correlated with an increased risk of developing CKD. Additionally, increases of HDL-cholesterol level, LDL-cholesterol/ApoB and HDL-cholesterol/ApoAI ratios seemed to be protective [30]. …”

Section: Uremic Lipoproteins Evidences Of Toxicitymentioning

confidence: 99%

Modified Lipids and Lipoproteins in Chronic Kidney Disease: A New Class of Uremic Toxins

Florens

Calzada

Lyasko

et al. 2016

Toxins

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Chronic kidney disease (CKD) is associated with an enhanced oxidative stress and deep modifications in lipid and lipoprotein metabolism. First, many oxidized lipids accumulate in CKD and were shown to exert toxic effects on cells and tissues. These lipids are known to interfere with many cell functions and to be pro-apoptotic and pro-inflammatory, especially in the cardiovascular system. Some, like F2-isoprostanes, are directly correlated with CKD progression. Their accumulation, added to their noxious effects, rendered their nomination as uremic toxins credible. Similarly, lipoproteins are deeply altered by CKD modifications, either in their metabolism or composition. These impairments lead to impaired effects of HDL on their normal effectors and may strongly participate in accelerated atherosclerosis and failure of statins in end-stage renal disease patients. This review describes the impact of oxidized lipids and other modifications in the natural history of CKD and its complications. Moreover, this review focuses on the modifications of lipoproteins and their impact on the emergence of cardiovascular diseases in CKD as well as the appropriateness of considering them as actual mediators of uremic toxicity.

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“…Some scholars already proposed the hypothesis of the common mechanism of glomerular sclerosis and arteriosclerosis [20]. The serum cholesterol levels, including the increase of low-density lipoprotein (LDL) and the decrease of high-density lipoprotein (HDL), all participate in the progression of CKD, which involves mechanisms such as cholesterol transport in the body, inflammatory status mediated by lipid toxicity in dyslipidemia, and increased cardiovascular risks [21]. The 2013 KIDIGO blood lipid management guideline recommends using all blood lipid indicators for the assessment of abnormal blood lipid profile conditions in patients; in addition, appropriate treatment intervention should be performed according to age and the level of kidney function [22].…”

Section: Discussionmentioning

confidence: 99%

Dynamic Analysis of Kidney Function and Its Correlation with Nutritional Indicators in a Large Sample of Hospitalized Elderly Patients

Wei

Wang

et al. 2017

Med Sci Monit

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BackgroundThe aim of this study was to analyze changes in kidney function and its correlation with nutritional metabolism indicators in hospitalized elderly patients in a large medical center over the past 7 years.Material/MethodsThe renal function of patients over 60 years old in the Chinese PLA General Hospital in 2008, 2011, and 2014 were comparatively analyzed. The hemoglobin, serum albumin, triglycerides, cholesterol, uric acid, and urea nitrogen data were collected and used as the nutritional metabolism indicators. In addition, the correlation between these indicators and the eGFR was analyzed.ResultsThe numbers of patients who received kidney function assessments in the 3 years were 15 752, 23 539, and 49 828; their mean ages were 69.97±6.99, 69.51±7.11, and 69.45±7.74 years. The median values of serum creatinine were 75.4, 76.5, and 77.5 μmol/L in the men and 59.6, 60.7, and 62.1 μmol/L in the women. The eGFR in both sexes demonstrated a gradual decreasing trend over the 3 years. According to the CKD staging method, analysis of the different percentages of eGFR intervals in the patients showed that the percentages of the 3 groups with an eGFR lower than 60 mL/min/1.73 m2 exhibited a rising trend annually. Correlational analysis of the nutritional indicators showed that the correlations between Hb, ALB, TG, TC, Ur, and BUN with an eGFR lower than 60 mL/min/1.73 m2 were 0.582, 0.780, 1.219, 1.364, 2.180, and 3.677, respectively.ConclusionsSerum creatinine showed a gradually increasing trend over the 3 study years. The CKD-EPI equation calculation results showed that the eGFR in elderly people of both sexes gradually decreased. Reduction of hemoglobin and albumin was a risk factor for decreased kidney function, while increases in uric acid and blood lipids affected the progression of renal insufficiency.

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LDL-C/apoB and HDL-C/apoA-1 ratios predict incident chronic kidney disease in a large apparently healthy cohort

Cited by 30 publications

References 41 publications

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Modified Lipids and Lipoproteins in Chronic Kidney Disease: A New Class of Uremic Toxins

Dynamic Analysis of Kidney Function and Its Correlation with Nutritional Indicators in a Large Sample of Hospitalized Elderly Patients

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