Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Wen, Jie; Chen, Yiyin; Huang, Yun; Lu, Yao; Liu, Xing; Zhou, Hong‐Hao; Yuan, Hong

doi:10.1159/000485861

Cited by 31 publications

(24 citation statements)

References 48 publications

(64 reference statements)

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“…Apart from above investigations, researches also identified the utility of TG/HDL-C in identifying eGFR reduction as it incorporated both TG and HDL-C level. Ho et al demonstrated the correlation between TG/HDL-C with CKD, and Wen et al even showed the advantage of TG/HDL-C when compared with TG alone with respect to the development of CKD, confirmed our aforementioned hypothesis [ 13 , 14 ]. However, there was one point that worth to be mentioned, although TG/HDL-C had a robust association with CKD, it was not an ideal marker of eGFR reduction due to its low sensitivity and specificity [ 13 ].…”

Section: Discussionsupporting

confidence: 85%

“…Findings revealed that increased TG level was significantly correlated with CKD [ 9 – 11 ]. Furthermore, as a combination of 2 characteristics of dyslipidemia in CKD, TG to HDL-C ratio (TG / HDL-C) has also been identified to strongly associated with decline of eGFR in participants without CKD and rapid decrement of eGFR in participants with CKD [ 12 – 14 ]. Obesity is another condition that strongly correlated with decreased eGFR or CKD [ 8 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Value of reduced glomerular filtration rate assessment with cardiometabolic index: insights from a population-based Chinese cohort

Wang

Shi

Yi³

et al. 2018

BMC Nephrol

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BackgroundRecent studies have suggested that cardiometabolic index (CMI), a novel estimate of visceral adipose tissue, could be of use in the evaluation of cardiovascular risk factors. However, the potential utility and clinical significance of CMI in the detection of reduced estimated glomerular filtration rate (eGFR) remains uncertain. The purpose of this study was to investigate the usefulness of CMI in assessing reduced eGFR in the general Chinese population.MethodsThis cross-sectional analysis included 11,578 participants (mean age: 53.8 years, 53.7% females) from Northeast China Rural Cardiovascular Health Study (NCRCHS) of general Chinese population (data collected from January 2013 to August 2013). CMI was calculated by triglyceride to high density lipoprotein cholesterol ratio multiply waist-to-height ratio. Reduced eGFR was defined as eGFR< 60 ml/min per 1.73m2. Multivariate regressions were performed to determine CMI’s association with eGFR value and eGFR reduction, ROC analyses were employed to investigate CMI’s discriminating ability for decreased eGFR.ResultsThe prevalence of reduced eGFR was 1.7% in males and 2.5% in females. CMI was notably more adverse in reduced eGFR groups, regardless of genders. In fully adjusted multivariate linear models, each 1 SD increment of CMI caused 3.150 ml/min per 1.73m2 and 2.411 ml/min per 1.73m2 loss of eGFR before CMI reached 1.210 and 1.520 in males and females, respectively. In logistic regression analyses, per 1 SD increase of CMI brought 51.6% additional risk of reduced eGFR in males while caused 1.347 times of risk in females. After divided into quartiles, people in the top quartile of CMI had higher adjusted ORs of having reduced eGFR, with ORs of 4.227 (1.681, 10.627) and 3.442 (1.685–7.031) for males and females respectively. AUC of CMI was revealed to be 0.633 (0.620–0.646) in males and 0.684 (0.672–0.695) in females.ConclusionsHigher CMI was independently associated with greater burden of reduced eGFR, highlighting VAT distribution and dysfunction as a potential mechanism underlying the association of obesity with kidney damage and adverse cardiovascular outcomes. The findings from this study provided important insights regarding the potential usefulness and clinical relevance of CMI in the detection of reduced eGFR among general Chinese population.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Value of reduced glomerular filtration rate assessment with cardiometabolic index: insights from a population-based Chinese cohort

Wang

Shi

Yi³

et al. 2018

BMC Nephrol

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“…Clinical and biochemical data were obtained as previously described [22]. Briefly, baseline information on demographics, health-related habits, medical history, and current medication use was collected using a standardized questionnaire.…”

Section: Data Collectionmentioning

confidence: 99%

“…Briefly, baseline information on demographics, health-related habits, medical history, and current medication use was collected using a standardized questionnaire. Smoking or drinking was defined as 'current' (smoking or drinking in the past 6 months or quit smoking or drinking within the past 6 months), 'former' (had stopped smoking or drinking for more than 6 months), or 'never' [22]. Exercise habits were defined according to frequency per week (≤2 times/week or ≥3 times/week, with the latter indicating that the individual was physically active) [22].…”

Section: Data Collectionmentioning

confidence: 99%

Associations of non-high-density lipoprotein cholesterol, triglycerides and the total cholesterol/HDL-c ratio with arterial stiffness independent of low-density lipoprotein cholesterol in a Chinese population

Wen

Huang

et al. 2019

Hypertens Res

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Several lipid parameters are closely associated with residual cardiovascular risk. We aimed to confirm that in a range of lowdensity lipoprotein cholesterol (LDL-c) levels (from <70 mg/dl to ≥160 mg/dl), other lipid parameters, such as triglyceride (TG) level, non-high-density lipoprotein cholesterol (non-HDL-c) level, and the total cholesterol (TC)/HDL-c ratio, are still related to arterial stiffness, which is a recognized marker of atherosclerosis. In this cross-sectional study, we measured brachial-ankle pulse wave velocity (baPWV), as well as clinical and biochemical indices in 16,733 Chinese adult volunteers who underwent health checkups from January 2014 to January 2015. Arterial stiffness was defined as the upper quartile of baPWV. We applied multivariable logistic regression models to examine the associations between lipid parameters and arterial stiffness. Both men and women with high baPWV were more likely to have an atherogenic lipid phenotype. Among participants with LDL-c <70 mg/dl, participants with non-HDL-c ≥100 mg/dl had a multivariable adjusted OR for arterial stiffness of 1.66 (1.11-2.50) compared to those with non-HDL-c <100 mg/dl; participants with TG ≥150 mg/dl had an OR of 2.44 (1.61-3.71) compared to those with TG <150 mg/dl; and participants with a TC/HDL-c ratio ≥4 had an OR of 1.74 (1.15-2.65) compared to those with a TC/HDL-c ratio <4. Similar results were observed at other LDL-c levels. We found that non-HDL-c, TG, and the TC/HDL-c ratio were consistently associated with arterial stiffness in a range of LDL-c levels, even when LDL-c was below 70 mg/dl. These lipid measures are related to residual cardiovascular risk, possibly due to their detrimental effects on vascular structure. Keywords Low-density lipoprotein cholesterol • Non-high-density lipoprotein cholesterol • Triglycerides • Total cholesterol/ HDL-c ratio • Brachial-ankle pulse wave velocity • Arterial stiffness • Cardiovascular disease

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“…Several studies have reported that an elevated TG/ HDL-C ratio correlated with the prevalence of CKD [14,15]. However, conflicting data were reported on the association of high TG/HDL-C ratios with CVD and mortality in dialysis patients.…”

Section: Introductionmentioning

confidence: 99%

Elevated TG/HDL-C and non-HDL-C/HDL-C ratios predict mortality in peritoneal dialysis patients

et al. 2020

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Background and aims: Dyslipidemia is common in patients with chronic kidney disease and particular prevalent in patients receiving peritoneal dialysis. However, whether markers of atherogenic dyslipidemia correlate with outcomes in dialysis patients as in the general population is uncertain. The aim of this study was to explore the prognostic value of the serum triglyceride/HDL cholesterol (TG/HDL-C) ratio and non-HDL-C/HDL-C ratio to predict mortality in peritoneal dialysis patients. Methods: Two hundred fourteen peritoneal dialysis patients were retrospectively analyzed from January 2011 to December 2015, with a median follow-up of 59 months. We used receiver operating curves (ROC) to determine the optimal threshold for TG/HDL-C and non-HDL/HDL-C ratios at baseline to predict overall survival during follow-up. Prognostic values were accessed by univariate and multivariate COX regression analysis and Kaplan-Meier curve. A predictive nomogram was developed to predict prognosis for overall survival, and the predictive accuracy was evaluated by concordance index (c-index). Results: The optimal cutoff values for TG/HDL-C ratio and non-HDL-C/HDL-C ratio to predict mortality were 1.94 and 2.86, respectively. A high TG/HDL-C ratio and a high non-HDL-C/HDL-C ratio strongly correlated with worse overall survival in peritoneal dialysis patients. Multivariate analysis demonstrated that elevated TG/HDL-C ratio (HR 3.57, 95% CI 1.99, 6.39, P < 0.000) as well as non-HDL/HDL-C ratio (HR 2.58, 95%CI 1.39-4.81, P = 0.003) were independent markers to predict reduced OS. A nomogram was constructed to predict overall survival, with a cindex for predictive accuracy of 0.795. Conclusion: TG/HDL-C ratio and non-HDL-C/HDL-C may serve as potential prognostic biomarkers in PD patients.

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Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Cited by 31 publications

References 48 publications

Value of reduced glomerular filtration rate assessment with cardiometabolic index: insights from a population-based Chinese cohort

Value of reduced glomerular filtration rate assessment with cardiometabolic index: insights from a population-based Chinese cohort

Associations of non-high-density lipoprotein cholesterol, triglycerides and the total cholesterol/HDL-c ratio with arterial stiffness independent of low-density lipoprotein cholesterol in a Chinese population

Elevated TG/HDL-C and non-HDL-C/HDL-C ratios predict mortality in peritoneal dialysis patients

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